<p>Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network</p>

Abstract

Introduction: Clinical adoption of genomic medicine has lagged behind the pace of scientific discovery. Practice-based resources can help overcome implementation challenges. Methods: In 2015, the IGNITE (Implementing GeNomics In pracTicE) Network created an online genomic medicine implementation resource toolbox that was expanded in 2017 to incorporate the ability for users to create targeted implementation guides. This expansion was led by a multidisciplinary team that developed an evidence-based, structured framework for the guides, oversaw the technical process/build, and pilot tested the first guide, CYP2C19-Clopidogrel Testing Implementation. Results: Sixty-five resources were collected from 12 institutions and categorized according to a seven-step implementation framework for the pilot CYP2C19-Clopidogrel Testing Implementation Guide. Five months after its launch, 96 CYP2C19-Clopidogrel Testing Implementation Guides had been created. Eighty percent of the resources most frequently selected by users were created by IGNITE to fill an identified resource gap. Resources most often included in guides were from the test reimbursement (22%), Implementation support gathering (22%), EHR integration (17%), and genetic testing workflow steps (17%). Conclusion: Lessons learned from this implementation guide development process provide insight for prioritizing development of future resources and support the value of collaborative efforts to create resources for genomic medicine implementation.

Knowledge and Attitudes of Medical and Health Science Students in the United Arab Emirates toward Genomic Medicine and Pharmacogenomics: A Cross-Sectional Study

“…The students ranked internet-based courses as their third preference in educational approach, which can craft the strategy to remedy the current gap in knowledge. Existing resources on the Internet consolidate this reciprocity of knowledge [ 1 , 36 , 37 , 38 , 39 , 40 , 41 ]. Moreover, we explored the students’ perceived barriers to the full implementation of genomic medicine and PGX in the UAE.…”

Potential Use of Pharmacogenetics to Reduce Drug-Induced Syndrome of Inappropriate Antidiuretic Hormone (SIADH)

“…Although the field of pharmacogenetics has made great strides in assessing markers of risk for many clinically severe adverse drug reactions, the genetic architecture underlying drug-induced SIADH remains relatively uncharacterized. Large observational cohorts are now positioning themselves to address these and other similar questions retrospectively [ 41 ], and multi-institutional consortia are creating robust infrastructure to quantify the impact of gene-based dosing prospectively through pragmatic clinical trials involving many of these drugs [ 42 ].…”

Realities of Pharmacogenomic and Minimizing Misconceptions and Medication Misadventures

“…The implementation science framework that was used to design the implementation guide can be applied other specific drug-gene interactions of interest or a PGx process in general. 8 The initial steps identified include ensuring there is sufficient evidence, laboratory testing process, reimbursement, clinical decision support, and education.…”