&lt;p&gt;Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System&lt;/p&gt;

Jian-xian, Chen; Saleem, Kalsoom; Ijaz, Munazza; Ur-Rehman, Masood; Murtaza, Ghulam; Asim, Mulazim Hussain

doi:10.2147/ijn.s250242

Cited by 28 publications

(32 citation statements)

References 34 publications

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“…The produced mixtures had a range of hydrophilic-lipophilic balance (HLB) values within the range of 6.55 to 14.22. Although the characterization of SEDDs is mainly conducted using either distilled or deionized water as the dispersing medium [34,[55][56][57]], yet, in this work, the self-emulsification efficiency of various mixtures was evaluated on the bases of the produced droplet size (DS), dispersity (Ð) and transmittance percentage (T%), in three different diluents namely: distilled water (DW), 0.1 mM HCl (pH = 4), and simulated intestinal fluids (SIF) (pH = 6.8) for mimicking the oral route of administration and select the most physically stable formulation(s) [58,59]. All the used diluents were freshly prepared and filtered through a 0.45 µm nylon membrane filter before use.…”

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confidence: 99%

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

et al. 2020

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Azithromycin (AZM) is a macrolide antibiotic used for the treatment of various bacterial infections. The drug is known to have low oral bioavailability (37%) which may be attributed to its relatively high molecular weight, low solubility, dissolution rate, and incomplete intestinal absorption. To overcome these drawbacks, liquid (L) and solid (S) self-emulsifying drug delivery systems (SEDDs) of AZM were developed and optimized. Eight different pseudo-ternary diagrams were constructed based on the drug solubility and the emulsification studies in various SEDDs excipients at different surfactant to co-surfactant (Smix) ratios. Droplet size (DS) < 150 nm, dispersity (Đ) ≤ 0.7, and transmittance (T)% > 85 in three diluents of distilled water (DW), 0.1 mM HCl, and simulated intestinal fluids (SIF) were considered as the selection criteria. The final formulations of L-SEDDs (L-F1(H)), and S-SEDDs (S-F1(H)) were able to meet the selection requirements. Both formulations were proven to be cytocompatible and able to open up the cellular epithelial tight junctions (TJ). The drug dissolution studies showed that after 5 min > 90% and 52.22% of the AZM was released from liquid and solid SEDDs formulations in DW, respectively, compared to 11.27% of the pure AZM, suggesting the developed SEDDs may enhance the oral delivery of the drug. The formulations were stable at refrigerator storage conditions.

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confidence: 99%

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

et al. 2020

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“…Briefly, these instabilities include phase separation, phase inversion, creaming, cracking, sedimentation, flocculation, aggregation, coalescence and Ostwald ripening. These are customarily caused by fluctuating temperatures, absence of emulsifiers, dissimilarities in the density of oil and water phases, as well as the high polydispersity index (PDI) values, which indicate the size distribution of droplets in emulsions [65,[120][121][122].…”

Section: Shortcomings Of Oral Liquid Self-emulsifying Drug Delivery S...mentioning

confidence: 99%

Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria

Seo¹,

Plessis²,

Viljoen³

2022

Pharmaceuticals

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Malaria affects millions of people annually, especially in third-world countries. The mainstay of treatment is oral anti-malarial drugs and vaccination. An increase in resistant strains of malaria parasites to most of the current anti-malarial drugs adds to the global burden. Moreover, existing and new anti-malarial drugs are hampered by significantly poor aqueous solubility and low permeability, resulting in low oral bioavailability and patient noncompliance. Lipid formulations are commonly used to increase solubility and efficacy and decrease toxicity. The present review discusses the findings from studies focusing on specialised oral lipophilic drug delivery systems, including self-emulsifying drug delivery systems (SEDDSs). SEDDSs facilitate the spontaneous formation of liquid emulsions that effectively solubilise the incorporated drugs into the gastrointestinal tract and thereby improve the absorption of poorly-soluble anti-malaria drugs. However, traditional SEDDSs are normally in liquid dosage forms, which are delivered orally to the site of absorption, and are hampered by poor stability. This paper discusses novel solidification techniques that can easily and economically be up-scaled due to already existing industrial equipment that could be utilised. This method could, furthermore, improve product stability and patient compliance. The possible impact that solid oral SEDDSs can play in the fight against malaria is highlighted.

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“…𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑝𝑜𝑤𝑑𝑒𝑟 𝐵𝑢𝑙𝑘 𝑣𝑜𝑙𝑢𝑚𝑒 𝑜𝑓 𝑝𝑜𝑤𝑑𝑒𝑟 (1) Tapped Density Determination 25 gm of drug previously passed through sieve # 20 was weighed and transferred in a 100 ml graduated cylinder. The cylinder was then fitted on a tap density apparatus and allowed for 500 taps.…”

Section: Bulk Density =mentioning

confidence: 99%

“…Disorders caused by Varicose veins and venous diseases impediments are comprehend to affect more than a quarter of the adult population, and the treatment of these illnesses are the primary cause of medical cost. Chronic venous insufficiency (CVI) is a disorder categorized by vicissitudes, which take place in leg secondary tissues due to prolonged venous hypertension caused by structural or functional abnormalities of the veins and/or venous valves [1,2]. Tablets are the most common concrete dose form in contemporary use.…”

Section: Introductionmentioning

confidence: 99%

Formulation, Development, and In-Vitro Evaluation of a Film-Coated Tablet Containing a Flavonoid Diosmin and Hesperidin Combination

Patil¹,

Malpure²,

Jadhav³

2022

Pharmacophore

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In this study combination of diosmin and hesperidin was used for the treatment of a condition called chronic venous insufficiency. diosmin and hesperidin are citrus bioflavonoids that act as a vascularprotecting agents used to treat chronic venous insufficiency, hemorrhoids, lymphedema, and varicose veins. A preformulation study was carried out for the formulation of the tablet of the selected drug. A compatibility study was carried out between diosmin and hesperidin along with excipients like Avicel pH 101, Klucel EXF, Sodium Starch Glycolate, and Magnesium stearate. Formulation of tablets was carried out in various trials. Trial 1 consists of two batches, F1 and F2 but due to disintegration issues, the formula was modified and trial 2 of batch F3 and F4 was carried out. Batch F2 and F3 were found to be of low hardness and high disintegration time. Trial 3 was conducted for batches F5, F6, and F7 where binders like polyvinyl pyrrolidone, Ac-Di-Sol, and Klucel EF were used. Batch F8 and F9 were formulated as trial 4 with Klucel EXF. Batch F8 produced a satisfactory result and hence coated with agent Wincoat WT-QCAQ-1261 Brown. Batch 8-V has shown acceptable results of disintegration time and was subjected to a stability study. Finally, a concluding manufacturing process was formulated depending on the obtained results.

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<p>Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System</p>

Cited by 28 publications

References 34 publications

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

Liquid and Solid Self-Emulsifying Drug Delivery Systems (SEDDs) as Carriers for the Oral Delivery of Azithromycin: Optimization, In Vitro Characterization and Stability Assessment

Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria

Formulation, Development, and In-Vitro Evaluation of a Film-Coated Tablet Containing a Flavonoid Diosmin and Hesperidin Combination

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