<p>Curcumin and endometrial carcinoma: an old spice as a novel agent</p>

Abstract

One of the clinically major gynecological cancers is endometrial carcinoma that develops from the lining of the uterus. During the past years, different approaches have been developed to treat endometrial carcinoma, among which natural herbal medicine has recently faired as an effective method. The yellow Indian spice known as curcumin has been extolled for its healing powers and has recently been adopted for investigation by the scientific community as a potent anti-cancerous agent. This review focuses on the effect of curcumin on endometrial cancer (EC) and its role in specific pathways involved in carcinogenesis.

Curcumin as an Alternative Medicine for Terminal Stage Endometrial Cancer Patient (Case Report)

“…Eventhough curcumin is a promising drug for mono or combination therapy for endometrial cancer, it is still not enough research in human. Research cautiously extrapolate results from experiments which were done either in vitro or in vivo in rodents, zebrafish and human beings drawn the conclusions curcumin has a significant effect on endometrial carcinoma where it exhibited pro-apoptotic, anti-proliferative, and anti-migratory activities of endometrial tumor cells [1], [2][6] [19] [21]. In this clinical case we could not prove with pathways of curcumin treatment lead to increase the patient survival rate dramatically for more than two years and prolong relapse of endometrial cancer for more than one year.…”

“…Endometrial cancer (EC) is a group of epithelial malignancies that occurs in the endometrium of perimenopausal or postmenopausal women [1]. In the US alone, uterine cancer is the fourth most diagnosed type of cancer in women [2]. Data from Indonesian Academic Hospital in the year 2007 showed that uterine cancer is the third most diagnosis gynecology type of cancer after cervical cancer and ovarian cancer [3].…”

“…Data from the population-based cancer registry in Jakarta Province showed that uterine cancer is one of the leading cancers among females with incidence rate is 1.76 per 100,000 females in 2005-2007 [4]. Intrusive interventions are the usual approach for the treatment of endometrial carcinoma such as surgery (mainly hysterectomy and salpingo-oophorectomy) and other alternatives or complimentary treatments including radiation therapy (brachytherapy or external beam radiation therapy), chemotherapy, and hormone therapy [2]. Todo et all reported that the survival rate of lymphadenectomy is restricted in low-risk patients; however, in intermediate or high risk patients, complete or systematic lymphadenectomy in both the pelvic and para-aortic regions has substantial therapeutic effects [5].…”

“…In terminal stage patient, the intrusive interventions have low sucessfull result but the side effect increases among most of the patient. With the exponential advancement of science, new promising therapies are being developed to treat different types of cancers, and among these remedies herbal medicine is being taken into serious consideration [2]. Curcumin, a widely used in Chinese herbal medicine, has historically been used as anti-cancer therapies [6].…”

Enhancement of curcumin antitumor efficacy and further photothermal ablation of tumor growth by single-walled carbon nanotubes delivery system in vivo

“…Curcumin (Cur), a hydrophobic polyphenol compound extracted from the rhizome of Curcuma longa L., has exhibited extensive anti-tumor potential in a wide range of cancer, such as breast, colon, colorectal, pancreatic, prostate, esophageal, head and neck cancers, endometrial carcinoma, and glioblastoma multiforme (El Khoury et al., 2019; Forouzanfar et al., 2019; Karavasili et al., 2019; Komal et al., 2019; Shahcheraghi et al., 2019; Yeung et al., 2019). Moreover, Cur can inhibit the invasion and metastasis of various cancers (Li & Zhang, 2014; Shafabakhsh et al., 2019; Wang et al., 2019).…”