&lt;p&gt;CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact&lt;/p&gt;

Niu, Fei; Ke, Qing; Qi, Hongyan; Zhao, Yijie; Jiang, Yingying; Jia, Wang; Sun, Ming

doi:10.2147/ndt.s266136

Cited by 5 publications

(2 citation statements)

References 45 publications

(60 reference statements)

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“…11,12 A previous study revealed that CPCGI exerts protective effects against TBI by upregulating the Nrf2 signaling pathway, lessening oxidative stress and suppressing the overactivation of calpain. 13 This study primarily investigated whether CPCGI protects the brain against TBI through repressing both mitochondrial apoptotic and PARP/NF-κB inflammatory signaling after TBI.…”

Section: Introductionmentioning

confidence: 99%

<p>Antiapoptotic and Anti-Inflammatory Effects of CPCGI in Rats with Traumatic Brain Injury</p>

Niu¹,

Ke²,

Qi³

et al. 2020

NDT

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Section: Introductionmentioning

confidence: 99%

<p>Antiapoptotic and Anti-Inflammatory Effects of CPCGI in Rats with Traumatic Brain Injury</p>

Niu¹,

Ke²,

Qi³

et al. 2020

NDT

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“…found that GM1, the active ingredient of CPCGI, inhibited in ammation and activation of NF-κB signaling pathway, respectively. Meanwhile, a recent study proved that CPCGI could reduce cortical neuronal apoptosis by inhibiting NF-κB signaling pathway in traumatic brain injury [35]. Conversely, we concluded that CPCGI attenuates hippocampal in ammation and thus reduces neuronal apoptosis by inhibiting the phosphorylation expression level of NF-κB signaling pathway.…”

Section: Declarations Ethics Approvalmentioning

confidence: 67%

Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injury

Tian

et al. 2023

Preprint

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Background Cerebral ischemia-reperfusion injury (CIRI) can cause hippocampal inflammation and apoptosis, resulting in anxiety and cognitive dysfunction. Compound porcine cerebroside and ganglioside injections (CPCGI) are used to treat encephalopathy, but its therapeutic effects and mechanism require further exploration. Methods We screened key genes associated with the ischemic stroke (IS) and predicted their binding sites with CPCGI. We subsequently injected CPCGI into a middle cerebral artery occlusion (MCAO) rat model. 2,3,5-triphenyl tetrazolium chloride (TTC) staining and behavioral testing were performed. Hippocampal neuronal apoptosis was assessed by immunofluorescence. IL-1β, TNF-α, and NF-κB pathway were detected by Western blotting. Oxygen-glucose deprivation/reoxygenation (OGD/R)-HT-22 cells were treated CPCGI for 72 h. Cell viability and NF-κB were also evaluated. Results H2AC20, RPL3, RPL13A, RPL9, RPS23, and RPLP0 were identified as key IS genes. CPCGI was confirmed to interact with these proteins via molecular docking. Functional enrichment reflected the critical role of the NF-κB pathway in CIRI. Infarct volume and behavioral impairments in MCAO rats, especially anxiety and cognitive dysfunction, were improved by CPCGI in a dose-dependent manner. Immunofluorescence confirmed that hippocampal neuronal apoptosis was rescued by the CPCGI. Western blotting revealed that inflammation and NF-κB phosphorylation were inhibited. In vitro experiments showed that CPCGI increased the survival of OGD/R-HT-22 cells and inhibited phosphorylation of the NF-κB signaling pathway. Conclusion CPCGI can alleviate anxiety and cognitive dysfunction in CIRI and thus improve psychoneurological symptoms in patients with IS. We confirmed that CPCGI alleviate inflammation and apoptosis in the hippocampus by inhibiting the NF-κB signaling pathway.

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Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Chen,

Zhang,

Zhang

et al. 2023

Ibrain

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Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat stroke. The study was initiated because of the high incidence of low‐does CPCGI use in our area. However, no research has confirmed the effectiveness of CPCGI below the standard dose. Therefore, the aim of this study was to provide a reference for the clinical selection of different dose treatments. We collected ischemic stroke patients and divided them into three groups (low‐dose group: Group A = 4 mL, Group B = 6 mL, standard‐dose group: Group C = 10 mL). The modified Rankin Scale (mRS) scores, the National Institutes of Health Stroke Scale (NIHSS) scores, and the Barthel Index (BI) scores were performed before treatment and 14 days and 90 days post CPCGI treatment. For 90 days, the primary outcomes were calculated including the degree of disability, neurological recovery, and activities of daily living. All data were compared between pretherapy and posttreatment and among groups. NIHSS, mRS and BI scores improved on 14 and 90 days in each group. Group B and C improved than Group A on 14 and 90 days. The difference between groups B and C was not statistically significant. On 90 days, there were differences in the degree of disability, the recovery of neurological function, and the ability of daily living among groups. No drug‐related adverse reactions occurred in the groups. Although 4 or 6 mL CPCGI had some neuroprotective effects, the standard dose of 10 mL CPCGI had the best effect on reducing the degree of disability and improving abilities of daily living.

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<p>CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact</p>

Cited by 5 publications

References 45 publications

<p>Antiapoptotic and Anti-Inflammatory Effects of CPCGI in Rats with Traumatic Brain Injury</p>

<p>Antiapoptotic and Anti-Inflammatory Effects of CPCGI in Rats with Traumatic Brain Injury</p>

Compound porcine cerebroside and ganglioside injections improved anxiety and cognitive dysfunction through the NF-κB pathway in cerebral ischemia-reperfusion injury

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

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