&lt;p&gt;Correlation Between Diabetic Peripheral Neuropathy and Sarcopenia in Patients with Type 2 Diabetes Mellitus and Diabetic Foot Disease: A Cross-Sectional Study&lt;/p&gt;

Yang, Qin; Zhang, Yingxiao; Zeng, Qinglian; Yang, Chan; Shi, Jiale; Zhang, Chunlin; Ni, Xia; Du, Zhenggui; Tang, Ziwei; Hu, Jinbo; Li, Xuemei; Cai, Jiahui; Li, Qifu; Cheng, Qingfeng

doi:10.2147/dmso.s237362

Cited by 34 publications

(33 citation statements)

References 41 publications

(50 reference statements)

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“…The possible reasons for this variation could be different study settings and different classi cation used to diagnose DPN in these studies. The prevalence of DPN found in present study was lower as compared to study conducted by Yang Q et al [19] and Qin L et al [20] in which prevalence of DPN was close to 71.0% and 80.0% respectively due to the similar reason as they used Neuropathy symptom score (NSS) and Neuropathy disability score (NDS) to assess DPN in their study population. High prevalence of DPN is a matter of concern for clinicians and public health specialists working with diabetic patients as this may lead to ulceration, amputation, life-long disability, and poor quality of life [21].…”

Section: Discussioncontrasting

confidence: 45%

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Bashar¹,

Verma²

2020

Preprint

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Background Diabetic peripheral neuropathy (DPN), a common and troublesome complication in patients with type 2 diabetes mellitus (T2DM), contributes to a higher risk of diabetic foot ulcer and lower limb amputation. These situations can negatively impact the quality of life of affected individuals.Objectives The study aimed to assess prevalence of DPN in patients of type 2 DM from rural North India and associated risk factors. Methods A facility based cross sectional study was carried out among type 2 diabetic patients attending NCD clinic of a secondary care hospital in rural North India. A questionnaire which included socio-demographic details, clinical and laboratory parameters, and the Michigan Neuropathy Screening Instrument (MNSI) for detecting peripheral neuropathy, was administered to 100 consecutive patients. Statistical Package for Social Sciences (SPSS) version 25.0 was used for entering and analyzing data. Bivariate analysis was performed for determining the factors significantly associated with presence of DPN. Results The prevalence of DPN was 42.0%. Male gender, advancing age(≥60 years), longer duration of diabetes (>10 years ), smoking, physical inactivity, obesity, uncontrolled blood pressure, poor A glycaemic control and altered lipid profile were found to be significantly associated with the presence of DPN. Conclusion Prevalence of DPN among type 2 diabetics from rural north India is alarmingly high. There is need of essential screening of all diabetic patients by their primary care provider for early detection of DPN particularly in rural India.

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Section: Discussioncontrasting

confidence: 45%

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Bashar¹,

Verma²

2020

Preprint

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“…The main causes of DPN are metabolic disorders and vascular damage [ 2 ]. DPN presents as a wide spectrum of symptoms, such as sensory loss, pain, and loss of muscle mass [ 3 ]. Although nerve conduction velocity is common in DPN patients, it is not easily or reliably diagnosed in DPN [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

Zhao

Xin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore the rules of Chinese herbal medicine (CHM) therapy. Methods. The clinical data of 216 patients with DPN and qi-yin deficiency syndrome were obtained, and the clinical features of the patients were assessed by cluster analysis. Relevant information was entered into the clinical diagnosis and treatment collection system, and data mining techniques were used to analyse the drug frequency, core CHM, CHM pair, and so on. Results. In this study, glycated haemoglobin (HbA1c) and homocysteine (HCY) were closely related to the pathogenesis of DPN. Overall, 162 patients had typical DPN syndrome characteristics, and we analysed 216 prescriptions, including 182 CHM. The frequencies of prescription of Astragalus membranaceus, Ligusticum wallichii, Poria cocos, and Radix Rehmanniae were greater than 45%. A Bayesian network analysis diagram showed that the 9 most common core CHM included Astragalus membranaceus, Ligusticum wallichii, Poria cocos, atractylodes rhizome, and Salvia miltiorrhiza Bge. According to the association rules of CHM, Radix Ophiopogon is used for Codonopsis pilosula; Astragalus membranaceus and atractylodes rhizome for Rehmannia are also frequently used. Astragalus membranaceus and Cinnamomi Ramulus or Ligusticum wallichii and Moutan bark were highly related to a decreased Michigan Diabetic Neuropathy Score. Conclusion. HbA1c and HCY are related risk factors for DPN. Numbness is a typical syndrome characteristic. Astragalus membranaceus is a monarch CHM and is used most frequently.

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“…Patients with T2DM with an HbA1c level higher than 8.0% were three to ve times at higher risk of limited lower extremity access than those with an HbA1c level > 5.5% [14]. A cross-sectional study showed that the average HbA1c levels were 7.9% in T2DM patients without sarcopenia and 8.4% in T2DM patients with sarcopenia [15].…”

Section: Discussionmentioning

confidence: 99%

A Cross-sectional Study: Association Between sarcopenia and Osteoporosis in Type 2 Diabetes Mellitus Patients With a High Glycated Hemoglobin Level

Lingna

et al. 2020

Preprint

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Abstract Background: Sarcopenia and osteoporosisare commonly observed in individuals with type 2 diabetes mellitus (T2DM).Thus, this study investigated the association between sarcopenia and osteoporosis in T2DM patients with a highglycated hemoglobin (HbA1c)level.Methods: This study recruited 98 Chinese patients with T2DM who were aged ≥ 50 years, and their body compositions were evaluated using dual-energy X-ray absorptiometry. Moreover, the fFasting blood glucose, HbA1c, B collagen-specific sequences (B-CTX), osteocalcin(OC), propeptide of type 1 procollagen(P1NP), 25-hydroxy vitamin Dlevels were evaluated.Sarcopenia was defined as skeletal muscle mass index (SMI) <7.0 kg/m2 for men and < 5.4 kg/m2 for women.Results: There were 42 men and 56 women, with an average age of 65.86 ± 8.32 years and HbA1c level of 8.59% ± 1.87%. The prevalence rates ofsarcopenia, osteopenia, and osteoporosis were48.0%, 37.8%, and 33.6%, respectively.Moreover, the prevalence of osteoporosis was significantly higher in women than in men (50% vs. 11.9%, P = 0.000).The prevalence of sarcopenia was significantly higher in patients with HbA1c levels> 9.0% than in those with HbA1c levels < 9.0% (62.2% vs. 39.3%, P = 0.037). However, the prevalence of osteopenia and osteoporosis in patients with HbA1c levels > 9.0% differed from those with HbA1c levels < 9.0%(29.5% vs.51.4% for osteopenia, 32.8% vs.35.1% for osteoporosis; P = 0.022). The height and weight of the osteoporosis group significantly decreased compared with those of the normal bone mineral density (BMD), whereas the serum BCTX, OC, and PINP levels significantly increased.The SMI, trunk muscles, skeletal muscle parameters, lumbar spine bone mineral content (BMC), lumbar spine BMD, femoral BMC, and femoral BMD decreased significantly in T2DM patients with osteoporosis.Sarcopeniawas associated with a higher height (odds ratio [OR] = 1.524, 95% confidence interval [CI] = 1.196-1.698, P = 0.000), lower body weight (OR = 0.735, 95% CI = 0.640-0.844, P = 0.000), and higher body fat content (OR = 1.211, 95% CI = 1.046-1.402, P = 0.011). Meanwhile, osteoporosis was correlated to a lower SMI (OR = 0.178, 95% CI = 0.044-0.817, P = 0.015).Conclusions: Ahigh HbA1c level was associated with a higher prevalence of sarcopenia and osteoporosis in T2DM patients, and low muscle masswas considered a risk factor for osteoporosis inthis group of patients.

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<p>Correlation Between Diabetic Peripheral Neuropathy and Sarcopenia in Patients with Type 2 Diabetes Mellitus and Diabetic Foot Disease: A Cross-Sectional Study</p>

Cited by 34 publications

References 41 publications

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

A Cross-sectional Study: Association Between sarcopenia and Osteoporosis in Type 2 Diabetes Mellitus Patients With a High Glycated Hemoglobin Level

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