<p>Combined iStent^® <em>Inject</em> Trabecular Micro-Bypass and Phacoemulsification in Australian Patients with Open-Angle Glaucoma</p>

Abstract

Purpose: This retrospective audit aimed to evaluate the impact of combined iStent ® Inject (iSI) and phacoemulsification on medication number in Australians with open-angle glaucoma. Secondary outcomes included intraocular pressure (IOP), best-corrected visual acuity, refraction and visual fields. Patients and Methods: Patients with glaucoma that received combined iSI and phacoemulsification by the same surgeon between 1 February 2016 and 1 February 2018 were audited for postoperative medication number, pressures after 1 day, 1 week, 4 weeks and 6, 12, 18 and 24 months, visual acuity, refraction and visual fields. These parameters were compared to baseline levels and with those from a separate cohort of patients without glaucoma that received standalone phacoemulsification. Results: Forty-one patients (63 eyes) received the combined procedure. Thirty-four patients (59 eyes) received standalone phacoemulsification. Four weeks after receiving combined iSI and phacoemulsification the mean medication number was significantly reduced by 1.3 (p < 0.001) for those on medication at baseline and by 0.5 (p = 0.002) overall. Mean IOP was significantly reduced from baseline after 6 months (-16%; p = 0.012; n = 35) and 12 months (-29%; p = 0.004; n = 16). Patients receiving standalone phacoemulsification had short-term reductions in IOP at 4 weeks (-8%; p < 0.001; n = 57) and 6 months (-16%; p < 0.001; n = 32). These patients without glaucoma had lower pressures overall compared to those with glaucoma that received the combined procedure (p = 0.019). There were no differences in final visual acuity or refractive outcomes between groups. Conclusion: This audit suggests that iSI and phacoemulsification are at least as effective in controlling IOP as medical therapy. It may have an important role in reducing the medication burden in Australians with cataract and glaucoma. This study is one of the first to confirm refractive stability in concomitant iSI and phacoemulsification.

Rates of visual field change and functional progression in glaucoma following trabecular microbypass implantation of iStent technologies: a meta-analysis

“…Out of these, eight were successive reports on the same initial cohorts, and a further two reports did not match our retention rates threshold (online supplemental material 1). Ultimately, a total of 15 articles were retained for analysis, with a collective dataset including 1115 eyes 16–31. Seven of these were prospective studies and two were randomised controlled trials.…”

“…Ultimately, a total of 15 articles were retained for analysis, with a collective dataset including 1115 eyes. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] Seven of these were prospective studies and two were randomised controlled trials. The PRISMA flow chart is included in figure 1.…”

Comparison of Phacoemulsification with and without Trabecular Micro-Bypass Stent in Primary Open-Angle Glaucoma and Normal Tension Glaucoma Population, 18 Months Outcome

“…However, the effectiveness of this treatment may vary depending on the individual's race and the type of glaucoma they have. [11][12][13][14][15] Taiwan, like many East Asian countries, has a high incidence of normal-tension glaucoma (NTG), a type of open-angle glaucoma that is characterized by glaucomatous optic neuropathy with consistently normal IOP. [16] While the angle structure and visual impairment of NTG and primary open-angle glaucoma (POAG) may be similar, their underlying pathological mechanisms may differ.…”