<p>Cognitive function, depression, and anxiety in patients undergoing radical prostatectomy with and without adjuvant treatment</p>

Abstract

Background Prostate cancer (PC) is one of the most common malignant tumors in developed countries. Both PC and treatment for PC have an adverse impact on physical and mental well-being, and are associated with decreased quality of life. The aim of the present study was to examine the relationship between neuropsychological symptoms and clinical course in PC patients undergoing radical prostatectomy with or without adjunct therapy. Methods The cohort comprised 100 patients aged 50–77 years who underwent radical, laparoscopic prostatectomy for PC. Twenty-three patients with a more advanced clinical stage also received adjuvant therapy (radiotherapy and hormonotherapy). Clinical evaluation included self-report assessment, physical examination, and biochemical tests (testosterone and prostate-specific antigen). In addition, the presence and intensity of sexual dysfunction, urinary dysfunction, anxiety-depressive symptoms, and cognitive dysfunction were assessed. Results The group of patients undergoing complex therapy was characterized by a significantly worse result of deferred memory ( p =0.04). A significant correlation was found between post-surgery erectile function and scores for the visual working memory test (correct answers; VWMT-C; p =0.006) and Hospital Anxiety and Depression Scale depression ( p =0.045) and anxiety scores ( p =0.02). A trend toward significance was also observed for simple reaction time (correct answers; p =0.09). A significant correlation was found between results for the delayed verbal memory test and all physical symptoms (International Consultation on Incontinence Questionnaire-total, p =0.02; International Index of Erectile Function-5, p =0.006). Similarly, a significant correlation was found between the VWMT-C and score for sexual dysfunction ( p =0.003). Conclusion Patients undergoing both surgical and adjunct therapy for PC are at risk for psychological burden and cognitive disorders. In the present cohort, physical complications of therapy were associated with depression, anxiety, and delayed memory dysfunction. Furthermore, this study has proven that fewer complications after surgery are associated with better psychological and cognitive functioning. Appropriate neuropsychological and psychiatric care can improve compliance and quality of life among patients after prostatectomy.

Is pre-operative urodynamic bladder function the true predictor of outcome of male sling for post prostatectomy incontinence?

“…Urinary incontinence is widely recognised as one of the most debilitating complications following prostatectomy, with significant impact of cancer survivors’ quality of life. Recent research on the psychological burden of PPI has demonstrated the extent of its detrimental effects, including increased cognitive dysfunction, anxiety and depression [ 19 , 20 ]. As a consequence, the selection of surgical treatment for PPI, and predicting the outcomes of surgery are critical metrics for prostate cancer survivors.…”

Glomerular filtration formulas to assess clinical and neuropsychological status in geriatric patients with chronic heart failure: a comparison of three formulas

“…The presence and severity of depression and anxiety symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Cognitive function was assessed using the computer-based test battery (Neurotest), which comprises the following [22]: -Simple reaction time test (SRT): to evaluate the speed and correctness of simple reactions to stimuli. The patient's task is to respond to the stimulus in the form of a green circle appearing on the computer screen.…”

Clinical Study of Memory Disorders in Aging Patients and Associated Pathology

“…We have found two cases with memory disorders and prostatic hypertrophy (5%). Jarzemski et al [64], reported delayed memory dysfunction in patients undergoing both surgical and adjunct therapy for radical prostatectomy.…”