&lt;p&gt;Clinical and Nutritional Determinants of Extrauterine Growth Restriction Among Very Low Birth Weight Infants&lt;/p&gt;

Khasawneh, Wasim; Khassawneh, Mohammad; Mazin, Mai; Al-Theiabat, Muath; Al-quraan, Tuka

doi:10.2147/ijgm.s284943

Cited by 6 publications

(8 citation statements)

References 28 publications

(38 reference statements)

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“…15 In a study by Khasawneh et al, the prevalence of EUGR was 80% among VLBW neonates at hospital discharge with SGA at birth, < two weeks delay in full feeding were independent predictor of EUGR along with suboptimal protein and calorie supplementation. 16 EUGR prevalence among preterm neonates inversely proportionate to gestational age was found by Clark et al 10 Makker et al, reported rates of EUGR in preterm < 28 weeks to be more compared to < 32 weeks (24.6% vs. 21.2%). 17 In the present study, the prevalence of EUGR among VLBW neonates born < 28 weeks were more compared to 28 -32 weeks (82.35% vs. 50.55%).…”

Section: Discussionmentioning

confidence: 84%

Extrauterine Growth Restriction among Very Low Birth Weight Neonate using Intergrowth 21st in a Neonatal Intensive Care Unit: A Retrospective Study

Panda

Meher²,

Jena

et al. 2022

J. Nepal Paedtr. Soc.

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Introduction: Extrauterine growth restriction (EUGR) is a universal problem but its prevalence using recent reference growth charts and morbidities associated with it are lacking. The study aims at estimating EUGR prevalence in very low birth weight (VLBW) neonates and its associated morbidities. Methods: All VLBW neonates admitted to NICU between Jan 2018 to June 2019 were analysed. Neonatal anthropometries were recorded on Intergrowth 21st gender based postnatal growth chart. EUGR was defined by weight below 10th percentile at discharge. Demographic profile and neonatal morbidities were compared between EUGR and non-EUGR by using unpaired t test and Chi-square test. Regression was used for identification of the risk factors. Results: Out of 148 VLBW neonates, 92 (62.1%) were male, 26 (17.56%) were below 1000 gm, 102 (68%) were EUGR at discharge. Mean (SD) birth weight and gestational age were 1202 (221) gms and 30.89 (2.77) wks respectively. Caesarean delivery, higher gestational age, lower birth weight, SGA at birth and prolonged duration to achieve full enteral feeding were significantly associated with EUGR (P < 0.05). Sepsis was significantly associated with EUGR (36.28% vs. 17.4%; P 0.022). EUGR babies needed longer hospital duration (24.56% vs. 16.78%; P 0.005) with a higher mean PMA at discharge (38.07 wks vs. 35.11 wks; P < 0.001). In regression model SGA at birth and delay in achieving full feeding were independent predictor of EUGR. Conclusions: In VLBW neonate, prevalence of EUGR at discharge was 68%. Sepsis was significantly associated with EUGR. SGA and delay in achieving full feeding were independent predictors of EUGR.

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Section: Discussionmentioning

confidence: 84%

Extrauterine Growth Restriction among Very Low Birth Weight Neonate using Intergrowth 21st in a Neonatal Intensive Care Unit: A Retrospective Study

Panda

Meher²,

Jena

et al. 2022

J. Nepal Paedtr. Soc.

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“…Suboptimal nutritional support in the first two weeks of life is one of the main factors related to EUGR. 32 One limitation of our study was not including data about caloric and protein supply during hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Assessment of nutritional status in preterm newborns admitted to a tertiary neonatal intensive care unit

Ruiz¹,

Bertonha²,

Virgilio³

et al. 2023

JPNC

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Introduction: The increase in survival rates of preterm newborns, especially newborns of very low birth weight and extreme low birth weight, has brought challenges to clinical practice: promoting adequate nutritional support to this population, to favor future neuropsychomotor growth and development, since the interaction between nutrition, growth, metabolic and genetic phenomena are determinant in subsequent health and quality of life. Objectives: Evaluate the incidence of extrauterine growth restriction (EUGR) in preterm newborns and describe the evolution of anthropometric parameters during hospitalization in the neonatal unit. Methods: Prospective cohort study included patients with birth weight ≤1500g and/or gestational age ≤32 weeks. Data collection of anthropometric parameters at birth and at hospital discharge, as well as data regarding clinical evolution and nutritional support. Descriptive statistics were used; comparisons of non-parametric data were used by the Mann-Whitney test and comparison of data matched by the Wilcoxon test, with a significance level of 5%. Results: The incidence of EUGR was 60.5%. There was a decrease in the Z score of weight (p<0.0001), length (p<0.0001) and head circumference (p<0.0001), comparing birth and hospital discharge. The evolution of weight was similar to that described in the literature and nutritional management showed late onset of parenteral and enteral nutrition. Patients with complications related to prematurity had a greater difference in Z-score of weight between birth and discharge. Conclusion: EUGR has a high incidence in preterm newborns, as a consequence of the impact of preterm birth, complications related to prematurity and nutritional practices implemented.

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“…Domestic and foreign guidelines have been revised and updated in the last 10 years, with the management of EN and PN becoming more active and standardized. Most of the previous multicenter studies have focused on VLBWI ( 9 , 33 ), and this is the first study to focus on the incidence and risk factors of “true EUGR” in VPI in China. The study design was of a prospective multicenter study, and the data on perinatal information, weight, length, HC, and other growth indicators of VPI were relatively complete and reliable.…”

Section: Discussionmentioning

confidence: 99%

“…Figueras-Aloy et al (2) have suggested a new term, "true EUGR", which refers to cases of EUGR without any evidence of fetal growth impairment (SGA at birth). The term "true EUGR" was used to differentiate EUGR related to postnatal growth failure among non-SGA infants from pre-programed EUGR related to inadequate antenatal nutritional status among SGA infants (9). Postnatal growth restriction in SGA infants is likely not of postnatal origin, but a continuation of the process that has previously 10.3389/fped.2022.876310 affected fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Analysis of “true extrauterine growth retardation” and related factors in very preterm infants—A multicenter prospective study in China

Shen

Mao

et al. 2022

Front. Pediatr.

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ObjectiveTo investigate the incidence and related factors of extrauterine growth retardation (EUGR) and “true EUGR” in very preterm infants (VPI) from different regions of China.Materials and methodsClinical data of VPI were prospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020. The infants were divided into a small for gestational age (SGA) group or non-SGA group at birth, with non-SGA infants at 36 weeks of gestation or at discharge being further divided into a EUGR group or a non-EUGR group. Infants in the EUGR and non-SGA group were defined as “true EUGR.” The general information of VPI, such as maternal complications during pregnancy, use of enteral nutrition and parenteral nutrition, and complications during hospitalization were compared between the groups.ResultsAmong the 2,514 VPI included in this study, 47.3, 41.5, and 33.3% of VPI were below the 10th percentile, and 22.6, 22.4, and 16.0% of VPI were below the 3rd percentile for weight, height, and head circumference at 36 weeks of gestation or at discharge, respectively, by the percentile on the 2013 Fenton curve. The incidences of EUGR and “true EUGR” evaluated by weight were 47.3 and 44.5%, respectively. Univariate analysis showed that there were statistically significant differences in the aspects of perinatal and nutritional characteristics, treatment, and complications between the groups. Multivariate analysis showed that in non-SGA infants, the cumulative caloric intake during the first week was a protective factor for “true EUGR,” while days to reach total enteral nutrition, late initiation of human milk fortifier, and moderate to severe bronchopulmonary dysplasia were independent risk factors for “true EUGR.”ConclusionMore attention should be paid to the nutritional management of VPI to prevent “true EUGR.” Cumulative caloric intake should be ensured and increased during the first week, total enteral nutrition should be achieved as early as possible, human milk fortifier should be added early, and moderate to severe bronchopulmonary dysplasia should be prevented. These strategies are very important for reducing the incidence of “true EUGR” in VPI.

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<p>Clinical and Nutritional Determinants of Extrauterine Growth Restriction Among Very Low Birth Weight Infants</p>

Cited by 6 publications

References 28 publications

Extrauterine Growth Restriction among Very Low Birth Weight Neonate using Intergrowth 21st in a Neonatal Intensive Care Unit: A Retrospective Study

Extrauterine Growth Restriction among Very Low Birth Weight Neonate using Intergrowth 21st in a Neonatal Intensive Care Unit: A Retrospective Study

Assessment of nutritional status in preterm newborns admitted to a tertiary neonatal intensive care unit

Analysis of “true extrauterine growth retardation” and related factors in very preterm infants—A multicenter prospective study in China

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