&lt;p&gt;Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis&lt;/p&gt;

Zhang, Shihao; Liu, Jiansheng; Yuan, Taiwen; Liu, Huiyu; Wan, Chengwei; Le, Yonghong

doi:10.2147/ijgm.s272996

Cited by 11 publications

(11 citation statements)

References 36 publications

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“…The extracellular signal-regulated kinases ERK1 and ERK2 are conserved and ubiquitous serine-threonine kinases involved in ERK/MAPK signaling pathway, which also play critical roles in cancer development and progression [ 10 ]. Until now, many genes have been reported to be involved in the progression of NSCLC by regulating ERK/MAPK pathway, such as c-MYC [ 12 ], MALAT1 [ 11 ], HMGB3 [ 21 ], and FAK [ 22 ]. In addition, a previous study suggested that CBX7 can suppress the progression of ovarian carcinoma by inhibiting the ERK/MAPK pathway [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Chromobox Homologue 7 Acts as a Tumor Suppressor in Both Lung Adenocarcinoma and Lung Squamous Cell Carcinoma via Inhibiting ERK/MAPK Signaling Pathway

Huang

Zhang

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Chromobox homologue 7 (CBX7) is a member of the polycomb group family that plays a pivotal role in regulating cellular processes in human cancers. This study aims to explore the function and underlying molecular mechanisms of CBX7 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). The expression of CBX7 in LUAD and LUSC tissues was analyzed by UALCAN and GEPIA based on the TCGA database. Cell viability and apoptosis were measured by CCK-8 and flow cytometry assays, respectively. Cell migration and invasion were detected by transwell assay. The functions of downregulated genes in LUAD were enriched via GO and KEGG pathway analyses. The mRNA expression of CBX7, ERK1/2, and p38 was determined by qRT-PCR, and the protein levels of CBX7, ERK1/2, p-ERK1/2, p38, and p-p38 were measured by Western blotting. Tumor xenograft model was established to validate the antitumor effect of CBX7. The expression of CBX7 and Ki-67 in tumor tissues was detected by immunohistochemistry. CBX7 was downregulated in the tissues and cells of both LUAD and LUSC. Low CBX7 expression was associated with a poor overall survival rate in LUAD patients. CBX7 overexpression inhibited the viability, migration, and invasion and promoted the apoptosis of LUAD and LUSC cells. In addition, the downregulated genes in LUAD were enriched in MAPK cascade (GO) and MAPK signaling pathway (KEGG). ERK/MAPK pathway was then determined as a downstream target of CBX7, which was inhibited by CBX7 overexpression in LUAD and LUSC cells. The overexpression of CBX7 inhibited the malignant progression of LUAD and LUSC cells probably via suppressing the ERK/MAPK signaling pathway in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Chromobox Homologue 7 Acts as a Tumor Suppressor in Both Lung Adenocarcinoma and Lung Squamous Cell Carcinoma via Inhibiting ERK/MAPK Signaling Pathway

Huang

Zhang

Lin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Thus, circ-FGFR3 acts as a sponge for miR-22-3p and upregulates Gal-1 mRNA expression, thereby activating the ERK1/2 signaling pathway, promoting tumor angiogenesis and inducing cancer cell invasion and proliferation ( 42 ). Zhang et al ( 43 ) also observed abnormally elevated circ0001313 and reduced miR-452 levels in NSCLC cells. Moreover, circ0001313 silencing or miR-452 overexpression significantly reduced NSCLC cell proliferation and invasion.…”

Section: Mapk/erk Signaling Pathway-related Circrna Molecules and Lung Cancermentioning

confidence: 94%

“…Moreover, circ0001313 silencing or miR-452 overexpression significantly reduced NSCLC cell proliferation and invasion. In addition, circ0001313 could competitively bind to miR-452 to upregulate high mobility group box 3, which increased ERK1/2 and p38MAPK phosphorylation, thus activating the ERK/MAPK pathway and contributing to NSCLC development ( 43 ). Based on these studies, it may be hypothesized that MAPK/ERK signaling pathway-related circRNA molecules could be used as biomarkers and therapeutic targets for lung cancer.…”

Section: Mapk/erk Signaling Pathway-related Circrna Molecules and Lung Cancermentioning

confidence: 99%

Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

Lai

Wang

et al. 2021

Oncol Lett

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The rapid increase in cancer morbidity and mortality worldwide is a major challenge for public health providers. Therefore, there is an urgent need to explore the molecular mechanism of tumorigenesis and identify potential diagnostic biomarkers and therapeutic methods. Circular RNA (circRNA) is characterized by a stable structure and tissue-specific expression; these features are useful in medical research and clinical applications. In recent years, with the development of high-throughput sequencing technology, the potential use of circRNA in cancer prognosis and treatment has been extensively explored. Abnormal circRNA expression interferes with specific signaling pathways such as the MAPK pathway; this phenomenon may provide potential diagnostic biomarkers and new therapeutic targets. The present article discusses the research progress on the regulatory roles of MAPK/ERK pathway-related circRNA molecules in the development and progression of different types of tumors. This review may provide insight into the development of circRNA-based cancer management strategies.

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“… 117 MAPK circ0001313 up overexpression of circ0001313 promotes NSCLC cell proliferation and invasion by sponging miR-452 to upregulate the expression of HMGB3, leading to activation of the MAPK signaling pathway Zhang et al. 118 circ-ZKSCAN1 up high expression of circ-ZKSCAN1 predicts poor prognosis in NSCLC patients, suggesting its potential as a diagnostic biomarker for NSCLC; overexpression of circ-ZKSCAN1 inactivates the MAPK signaling pathway by sponging miR-330-5p to upregulate the expression of FAM83A, leading to the inhibition of NSCLC cell proliferation Wang et al. 52 hsa_circ_0004050 down high expression of hsa_circ_0004050 predicts good prognosis in NSCLC patients; hsa_circ_0004050 promotes apoptosis and inhibits proliferation of NSCLC cells by targeting miR-1233-3p to upregulate the expression of DUSP9, leading to the inhibition of the ERK/JNK signaling pathway Wang et al.…”

Section: Overview Of Circrnasmentioning

confidence: 99%

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Liu

et al. 2022

Molecular Therapy - Nucleic Acids

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Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with covalently closed-loop structures, a high abundance, and tissue-specific expression patterns. They participate in various pathophysiological processes by regulating complex gene networks involved in proliferation, apoptosis, migration, and epithelial-to-mesenchymal transition (EMT), as well as metastasis. A growing number of studies have revealed that the dysregulation of circRNAs contributes to many aspects of cancer progression, such as its occurrence, metastasis, and recurrence, suggesting their great potential as efficient and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC. In this review, we systematically elucidate the characteristics, biogenesis, and functions of circRNAs and focus on their molecular mechanisms in NSCLC progression. Moreover, we highlight their clinical implications in NSCLC treatment.

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<p>Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis</p>

Cited by 11 publications

References 36 publications

Chromobox Homologue 7 Acts as a Tumor Suppressor in Both Lung Adenocarcinoma and Lung Squamous Cell Carcinoma via Inhibiting ERK/MAPK Signaling Pathway

Chromobox Homologue 7 Acts as a Tumor Suppressor in Both Lung Adenocarcinoma and Lung Squamous Cell Carcinoma via Inhibiting ERK/MAPK Signaling Pathway

Circular RNA regulates the onset and progression of cancer through the mitogen‑activated protein kinase signaling pathway (Review)

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

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