&lt;p&gt;CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1α Pathway&lt;/p&gt;

Wang, Jing; Huang, Kuo Chin; Shi, Lang; Zhang, Qingyong; Zhang, Shengchu

doi:10.2147/cmar.s265579

Cited by 35 publications

(32 citation statements)

References 41 publications

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“…Furthermore, it has been well defined that through their capability to simultaneously bind numerous miRNAs, circRNAs can act to sponge and inhibit the activity of various miRNAs [ 366 , 367 , 368 , 369 , 370 , 371 ], and similar to what is observed with many lncRNAs, this can result in profound alterations to the biological and metabolic processes important to tumorigenesis [ 368 ]. Studies have revealed that various circRNAs may act as oncogenic promoters in breast cancer [ 372 ], NSCLC [ 373 ], melanoma [ 374 ], gastric cancer [ 375 ], gallbladder cancer [ 376 ], and CRC [ 377 ] models. Furthermore, some of these studies have revealed that circRNAs may enhance carcinogenesis through impacting glycolysis and PKM2 expression levels ( Table 5 ).…”

Section: Emerging Areas Of Research Involving Pkm2mentioning

confidence: 99%

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs

Puckett

Alquraishi

Chowanadisai

et al. 2021

IJMS

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Pyruvate kinase is a key regulator in glycolysis through the conversion of phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that can exhibit diverse biological functions and outcomes. The pyruvate kinase isoenzyme type M2 (PKM2) controls cell progression and survival through the regulation of key signaling pathways. In cancer cells, the dimer form of PKM2 predominates and plays an integral role in cancer metabolism. This predominance of the inactive dimeric form promotes the accumulation of phosphometabolites, allowing cancer cells to engage in high levels of synthetic processing to enhance their proliferative capacity. PKM2 has been recognized for its role in regulating gene expression and transcription factors critical for health and disease. This role enables PKM2 to exert profound regulatory effects that promote cancer cell metabolism, proliferation, and migration. In addition to its role in cancer, PKM2 regulates aspects essential to cellular homeostasis in non-cancer tissues and, in some cases, promotes tissue-specific pathways in health and diseases. In pursuit of understanding the diverse tissue-specific roles of PKM2, investigations targeting tissues such as the kidney, liver, adipose, and pancreas have been conducted. Findings from these studies enhance our understanding of PKM2 functions in various diseases beyond cancer. Therefore, there is substantial interest in PKM2 modulation as a potential therapeutic target for the treatment of multiple conditions. Indeed, a vast plethora of research has focused on identifying therapeutic strategies for targeting PKM2. Recently, targeting PKM2 through its regulatory microRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) has gathered increasing interest. Thus, the goal of this review is to highlight recent advancements in PKM2 research, with a focus on PKM2 regulatory microRNAs and lncRNAs and their subsequent physiological significance.

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Section: Emerging Areas Of Research Involving Pkm2mentioning

confidence: 99%

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs

Puckett

Alquraishi

Chowanadisai

et al. 2021

IJMS

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“…Li et al showed that miR34a inhibitor promotes cell proliferation and glucose uptake, indicating the anti-TNBC effect of miR34a [ 47 ]. More recently, Wang et al demonstrated that miR-29a overexpression exerts inhibitory effect on proliferation, migration, and invasion of TNBC cells through targeting the anterior gradient 2 (ARG2)/HIF-1 α axis [ 28 ]. Furthermore, circular RNA circPVT1 was identified as a miR sponge, leading to suppressing the expression of miR-29a and promoting in vivo tumor growth [ 28 ].…”

Section: Roles Of Mitomirs In Regulating Metabolic Reprogramming Of Tnbcmentioning

confidence: 99%

“…The expression of several mitomiRs can potentially be regarded as predictive, diagnostic, and prognostic biomarkers for TNBC ( Table 5 ). A cluster of low-expressed mitomiRs is identified in tumor tissue [ 28 , 33 , 34 , 44 – 47 , 52 , 55 , 71 , 77 – 79 ], while some of them are high-expressed [ 32 , 53 , 79 , 80 ]. Of note, some mitomiRs showed clinical significance in predicting disease outcome.…”

Section: Prognostic Value Therapeutic Implications and Future Perspectivementioning

confidence: 99%

“…These strategies exert treatment effect by targeting various aspects implicated in mitochondrial homeostasis, including metabolic reprogramming, apoptosis, redox signaling, and mitochondrial calcium transport. Most common approaches employed genetic manipulation, including siRNA, shRNA, and antisense for mitomiR inhibition [ 28 , 52 , 59 , 80 ]. Although some approaches conducted by virus-based gene delivery demonstrated treatment efficiency [ 33 , 82 ], the potential adverse effects to humans must be taken into consideration in the future should they be registered for clinical trials.…”

Section: Prognostic Value Therapeutic Implications and Future Perspectivementioning

confidence: 99%

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Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

Lin

Chu

2021

Oxidative Medicine and Cellular Longevity

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Triple-negative breast cancer (TNBC) is characterized by poor outcome and the most challenging breast cancer type to treat worldwide. TNBC manifests distinct profile of mitochondrial functions, which dictates reprogrammed metabolism, fosters tumor progression, and notably serves as therapeutic targets. Mitochondrial microRNAs (mitomiRs) are a group of microRNAs that critically modulate mitochondrial homeostasis. By a pathway-centric manner, mitomiRs tightly orchestrate metabolic reprogramming, redox status, cell apoptosis, mitochondrial dynamics, mitophagy, mitochondrial DNA (mtDNA) maintenance, and calcium balance, leading to an emerging field of study in various cancer types, including TNBC. We herein review the recent insights into the roles and mechanism of mitomiRs in TNBC and highlight its clinical value in diagnosis and prognosis as well as vital advances on therapeutics of preclinical and clinical studies.

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“…Mechanistically, circPVT1 binds with miR-29a-3p to release AGR2 from its inhibitory effect. AGR2 has been found to increase expression of HIF-1α and then accelerated malignant features of breast cancer cells ( 22 ). CircPVT1 has also been shown to promote invasiveness and epithelial–mesenchymal transition (EMT) of neoplastic breast cells through sequestering miR-204-5p ( 23 ).…”

Section: In Vitro Studiesmentioning

confidence: 99%

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

et al. 2021

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CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR‐423‐5p, miR‐526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from in vitro, in vivo, and clinical investigations.

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<p>CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1α Pathway</p>

Cited by 35 publications

References 41 publications

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs

Advances in Understanding Mitochondrial MicroRNAs (mitomiRs) on the Pathogenesis of Triple-Negative Breast Cancer (TNBC)

A Concise Review on the Role of CircPVT1 in Tumorigenesis, Drug Sensitivity, and Cancer Prognosis

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