&lt;p&gt;Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity&lt;/p&gt;

Ettinger-Veenstra, Helene van; Lundberg, Peter; Alföldi, P.; Södermark, Martin; Graven‐Nielsen, Thomas; Sjörs, Anna; Engström, Maria; Gerdle, Björn

doi:10.2147/jpr.s189443

Cited by 58 publications

(45 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding that structural alterations in the cingulate cortex, insular cortex, prefrontal lobe, and thalamus, as well as the impaired integrity of periaqueductal WM and the external capsule primarily occurred in patients with painful DPN suggest focal abnormalities of pain perception and modulation of pain‐related pathways (Davis & Moayedi, ; Ossipov, Morimura, & Porreca, ). This finding was partially supported by the results of our supplementary independent component analysis, which showed lower intra‐network connectivity in a number of brain regions within the salience network (a network frequently involved in processing the salient attention‐demanding stimuli or experiences such as pain (van Ettinger‐Veenstra et al, ; Hemington, Wu, Kucyi, Inman, & Davis, )), including bilateral insula and the right ACC (Figure S3). Specifically, the ACC has been reported to be a pain‐intensity encoding region in both healthy volunteers and in animal models (Apkarian, Baliki, & Geha, ; Duerden & Albanese, ; Farrell, Laird, & Egan, ; Senapati et al, ).…”

Section: Discussionsupporting

confidence: 71%

Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

Zhang

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Although diabetic peripheral neuropathy (DPN) has long been considered a disease of the peripheral nervous system, recent neuroimaging studies have shown that alterations in the central nervous system may play a crucial role in its pathogenesis. Here, we used surface-based morphometry (SBM) and tract-based spatial statistics (TBSS) to investigate gray matter (GM) and white matter (WM) differences between patients with DPN (n = 67, 44 painless and 23 painful) and healthy controls (HCs; n = 88). Compared with HCs, patients with DPN exhibited GM abnormalities in the pre-and postcentral gyrus and in several deep GM nuclei (caudate, putamen, medial pallidum, thalamus, and ventral nuclear). They also exhibited altered WM tracts (corticospinal tract, spinothalamic tract, and thalamocortical projecting fibers). These findings suggest impaired motor and somatosensory pathways in DPN. Further, patients with DPN (particularly painful DPN) exhibited morphological differences in the cingulate, insula, prefrontal cortex, and thalamus, as well as impaired WM integrity in periaqueductal WM and internal and external capsules. This suggests pain-perception/modulation pathways are altered in painful DPN. Intermodal correlation analyses found that the morphological indices of the brain regions identified by the SBM analysis were significantly correlated with the fractional anisotropy of brain regions identified by the TBSS analysis, suggesting that the GM and WM alterations were tightly coupled. Overall, our study showed sensorimotor and pain-related GM and WM Youming Zhang and Minli Qu contributed equally to this work.

show abstract

Section: Discussionsupporting

confidence: 71%

Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

Zhang

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…(2020) study were rooted in the main idea that hyper-connectivity between these three networks (DMN, FPN, and SN) exists in the brains of individuals with chronic pain (Hemington et al, 2016;Napadow et al, 2010;van Ettinger-Veenstra et al, 2019). Those results suggest that levels of heightened connectivity between the triple network returned to a more healthy, lower level of connectivity post-ACT.…”

Section: Discussionmentioning

confidence: 99%

Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain

Meier

Ray

Waller

et al. 2020

Preprint

View full text Add to dashboard Cite

Chronic musculoskeletal pain affects the lives of over 50 million individuals in the United States, at a cost of more than $550 billion each year. Chronic pain leads to functional brain changes within those suffering from the condition. Not only does the primary pain network transform as the condition changes from acute to persistent pain, a state of hyper-connectivity also exists between the default mode, frontoparietal, and salience networks. Graph theory analysis has recently been used to investigate treatment-driven brain network changes. For example, current research suggests that Acceptance and Commitment Therapy(ACT) may reduce the chronic pain associated hyper-connectivity between the default mode, frontoparietal, and salience networks, as well as within the salience network. This study extended previous work by examining the associations between the three networks above and a meta-analytically derived pain network.Results indicate decreased connectivity within the pain network (including left putamen, right insula, left insula, and right thalamus) in addition to triple network connectivity changes after the four-week Acceptance and Commitment Therapy intervention.

show abstract

“…Illustration of node connections used in this study. Adapted from van Ettinger-Veenstra et al (2019) .…”

Section: The Sphere Model Of Consciousnessmentioning

confidence: 99%

“…It is thus more than just a qualitative experience or set of experiences ( Mordeniz, 2016 ). Beyond its immediate unpleasantness, emotions experienced in the anticipation of pain and in response to its meanings and perceived future consequences are related to the DMN and salience network ( Kucyi et al, 2014 ; van Ettinger-Veenstra et al, 2019 ). The overlap between the patterns of cerebral activity associated with feelings of pain, emotions, and motivational states in the ACC and insula is consistent with their contribution to basic aspects of self-representation, self-regulation, and consciousness ( Wiech et al, 2008 ).…”

Section: The Sphere Model Of Consciousnessmentioning

confidence: 99%

Reflections on Inner and Outer Silence and Consciousness Without Contents According to the Sphere Model of Consciousness

Paoletti¹,

Ben‐Soussan²

2020

Front. Psychol.

View full text Add to dashboard Cite

In the current hypothesis paper, we propose that focusing attention on silence can be used as a paradigm conceptually similar to sensory deprivation, to study consciousness without content. We briefly overview recent influential models of consciousness and consider how they assess the relationship between consciousness and contents. After discussing the strengths and weaknesses of current models, we suggest an extension based on the Sphere Model of Consciousness (SMC) and introduce new definitions for identification and self-awareness as states of consciousness. We further compare Paoletti’s theoretical model for the development of self with other influential models, highlighting similarities and differences. We conclude with a discussion of how attentional focus on silence can be empirically tested.

show abstract

<p>Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity</p>

Cited by 58 publications

References 56 publications

Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

Sensorimotor and pain‐related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy

Graph theory analysis of induced neural plasticity post-Acceptance and Commitment Therapy for chronic pain

Reflections on Inner and Outer Silence and Consciousness Without Contents According to the Sphere Model of Consciousness

Contact Info

Product

Resources

About