&lt;p&gt;Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study&lt;/p&gt;

Kang, Xin; Zhan, Lijun; Lu, Xiaoguang; Song, Jianbo; Zhong, Yilong; Wang, Yi; Yang, Yahui; Fan, Zhining; Jiang, Xiao Zheng; Sun, Ruru

doi:10.2147/dmso.s242698

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…Furthermore, the double treatment (GSOR) was able to produce the most significant number of GM modifications in obese rats, reducing potential pathobionts such as hoa5-07d05 ( Rikenellaceae group) [ 60 ], Turicibacter [ 61 ] and the lipid catabolizer Anaerovibrio , present in T2D rats [ 62 ]. Conversely, GSOR increased (1) Methanobrevibacter , a methanogen bacterium previously associated with studies bearing on lean animals [ 63 ], (2) Eubacterium, a potentially beneficial bacterium that forms part of the human gut microbiome core [ 64 ] and (3) Faecalibaculum , able to produce butyrate and lactic acid as major metabolic end products, which has been related with anti-obesity effects; this suggests their potential role as probiotic for preventive and therapeutic applications [ 38 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation

et al. 2022

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Background Obesity is a worldwide health problem and a significant risk factor for diabetes and cardiovascular diseases. Gut microbiota (GM) plays an essential role in obesity, and prebiotics such as polyphenols could be one way to improve microbial dysbiosis-induced obesity. Objective This study was designed to assess the effectiveness of grape seed and skin extract (GSSE), and/or orlistat on obese rats fed with high fat diet by targeting GM modulations. The impact of treatments was also studied in non-obese rats. Material and methods Rats were rendered obese or kept with a standard diet for three months. Then they were treated either with GSSE or orlistat or with the combined treatment (GSOR) during three months and then sacrificed. Adipose tissues, blood and faeces were collected and analyzed. Results In obese rats and to a lesser extent in non-obese rats, treatments decreased the weight of various adipose tissues and the serum levels of cholesterol, LDL, triglycerides, lipase, and CRP and increased HDL and adiponectin. GSOR treatment was even more efficient that orlistat. Obese rats had less GM diversity than non-obese rats and orlistat reduced it even more. However, diversity was restored with GSSE and GSOR treatments. Potential pathogenic Streptococcus alactolyticus/gallolyticus species were greatly increased in obese rats and drastically reduced with the treatments, as wells as other potential pathobionts. Conclusions GSSE exerts beneficial effects in obese rats and restores, at least partially, the observed dysbiosis. GSOR induced the highest beneficial effect. Moreover, the various treatments could also enhance physiological and GM modifications in non obese rats.

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Section: Discussionmentioning

confidence: 99%

Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation

et al. 2022

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“…However, elevated abundance of Prevotella are associated with inflammation, hypertension, insulin resistance, and liver disease [ 60 , 61 ]. In addition, Alloprevotella and Anerovibrio are present in individuals with colitis and chronic kidney disease [ 62 , 63 ], and rats with type 2 diabetes [ 64 ], respectively. Roseburia and Agathobacter are beneficial gut bacteria that produce SCFAs, particularly butyrate [ 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Multispecies probiotics alter fecal short-chain fatty acids and lactate levels in weaned pigs by modulating gut microbiota

Vasquez

Kim

et al. 2021

J Anim Sci Technol

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Short-chain fatty acids (SCFAs) are metabolic products produced during the microbial fermentation of non-digestible fibers and play an important role in metabolic homeostasis and overall gut health. In this study, we investigated the effects of supplementation with multispecies probiotics (MSPs) containing Bacillus amyloliquefaciens, Limosilactobacillus reuteri, and Levilactobacillus brevis on the gut microbiota, and fecal SCFAs and lactate levels of weaned pigs. A total of 38 pigs weaned at 4 weeks of age were fed either a basal diet or a diet supplemented with MSPs for 6 weeks. MSP administration significantly increased the fecal concentrations of lactate (2.3-fold; p < 0.01), acetate (1.8-fold; p < 0.05), and formate (1.4-fold; p < 0.05). Moreover, MSP supplementation altered the gut microbiota of the pigs by significantly increasing the population of potentially beneficial bacteria such as Olsenella, Catonella, Catenibacterium, Acidaminococcus, and Ruminococcaceae. MSP supplementation also decreased the abundance of pathogenic bacteria such as Escherichia and Chlamydia. The modulation of the gut microbiota was observed to be strongly correlated with the changes in fecal SCFAs and lactate levels. Furthermore, we found changes in the functional pathways present within the gut, which supports our findings that MSP modulates the gut microbiota and SCFAs levels in pigs. The results support the potential use of MSPs to improve the gut health of animals by modulating SCFAs production.

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“…The healt promoting effect of this change is based on the fact that Prevotellaceae UCG 001 is negatively correlated with markers of glucose and lipid metabolism disorders [ 84 ], and that patients with chronic kidney disease had lower Prevotellaceae UCG-001 than healthy controls [ 85 ]. However, a spontaneous diabetes type 2 rat model showed higher levels of Prevotellaceae UCG-001 compared with healthy Wistar rats [ 86 ]. On the other hand, although the higher abundance of Muribaculaceae in the POST group, which is described to be inversely associated with body weight [ 87 , 88 ], no effect was found in this regard in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats’ Microbiota and Immunity

et al. 2021

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Human milk serves as a model for infant formula providing nutritional solutions for infants not able to receive enough mother’s milk. Infant formulas aim to mimic the composition and functionality of human milk by providing ingredients reflecting those of the latest human milk insights, such as prebiotics, probiotics and postbiotics. The aim of this study was to examine the effects of the supplementation with a postbiotic (LactofidusTM) and its combination with the prebiotics short-chain galactooligosaccharides (scGOS) and long-chain fructooligosaccharides (lcFOS) in a preclinical model of healthy suckling rats. Pups were supplemented daily with LactofidusTM (POST group) and/or scGOS/lcFOS (P+P and PRE groups, respectively). Body weight and fecal consistency were analyzed. At the end of the study, immunoglobulin (Ig) profile, intestinal gene expression, microbiota composition and short chain fatty acid (SCFA) proportion were quantified. The supplementation with all nutritional interventions modulated the Ig profile, but the prebiotic mixture and the postbiotic induced differential effects: whereas scGOS/lcFOS induced softer feces and modulated microbiota composition and SCFA profile, Lactofidus™ upregulated Toll-like receptors gene expression. The use of the combination of scGOS/lcFOS and Lactofidus™ showed the effects observed for the oligosaccharides separately, as well as showing a synergistic impact on animal growth. Thus, the combined use of both products seems to be a good strategy to modulate immune and microbial features in early life.

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<p>Characteristics of Gastric Microbiota in GK Rats with Spontaneous Diabetes: A Comparative Study</p>

Cited by 13 publications

References 25 publications

Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation

Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation

Multispecies probiotics alter fecal short-chain fatty acids and lactate levels in weaned pigs by modulating gut microbiota

Effects of a Postbiotic and Prebiotic Mixture on Suckling Rats’ Microbiota and Immunity

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