&lt;p&gt;Cardiovascular Considerations in COVID19: A Comprehensive Review&lt;/p&gt;

Keihanian, Faeze; Bigdelu, Leila

doi:10.2147/tcrm.s264377

Cited by 10 publications

(13 citation statements)

References 72 publications

(107 reference statements)

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“…Remarkably, these and other serum proteins related to lipid metabolism were previously seen in SARS-CoV patients, presenting an altered lipid and glucose metabolism even 12 years after infection (Wu et al 2017 ). Further studies should evaluate the exact mechanisms by which coronaviruses affect lipid and glucose metabolism (Keihanian and Bigdelu 2020 ), since they could provide new insights regarding the adverse chronic cardiovascular complications.…”

Section: Discussionmentioning

confidence: 99%

The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo

Beltrán-Camacho

Eslava-Alcon

Rojas-Torres

et al. 2022

Mol Med

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Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already caused 6 million deaths worldwide. While asymptomatic individuals are responsible of many potential transmissions, the difficulty to identify and isolate them at the high peak of infection constitutes still a real challenge. Moreover, SARS-CoV-2 provokes severe vascular damage and thromboembolic events in critical COVID-19 patients, deriving in many related deaths and long-hauler symptoms. Understanding how these processes are triggered as well as the potential long-term sequelae, even in asymptomatic individuals, becomes essential. Methods We have evaluated, by application of a proteomics-based quantitative approach, the effect of serum from COVID-19 asymptomatic individuals over circulating angiogenic cells (CACs). Healthy CACs were incubated ex-vivo with the serum of either COVID-19 negative (PCR −/IgG −, n:8) or COVID-19 positive asymptomatic donors, at different infective stages: PCR +/IgG − (n:8) and PCR −/IgG + (n:8). Also, a label free quantitative approach was applied to identify and quantify protein differences between these serums. Finally, machine learning algorithms were applied to validate the differential protein patterns in CACs. Results Our results confirmed that SARS-CoV-2 promotes changes at the protein level in the serum of infected asymptomatic individuals, mainly correlated with altered coagulation and inflammatory processes (Fibrinogen, Von Willebrand Factor, Thrombospondin-1). At the cellular level, proteins like ICAM-1, TLR2 or Ezrin/Radixin were only up-regulated in CACs treated with the serum of asymptomatic patients at the highest peak of infection (PCR + /IgG −), but not with the serum of PCR −/IgG + individuals. Several proteins stood out as significantly discriminating markers in CACs in response to PCR or IgG + serums. Many of these proteins particiArticle title: Kindly check and confirm the edit made in the article title.pate in the initial endothelial response against the virus. Conclusions The ex vivo incubation of CACs with the serum of asymptomatic COVID-19 donors at different stages of infection promoted protein changes representative of the endothelial dysfunction and inflammatory response after viral infection, together with activation of the coagulation process. The current approach constitutes an optimal model to study the response of vascular cells to SARS-CoV-2 infection, and an alternative platform to test potential inhibitors targeting either the virus entry pathway or the immune responses following SARS-CoV-2 infection.

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Section: Discussionmentioning

confidence: 99%

The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo

Beltrán-Camacho

Eslava-Alcon

Rojas-Torres

et al. 2022

Mol Med

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“…Knowledge about short- and long-term complications of COVID-19 infection is growing worldwide [ 1 ]. COVID-19 is now a serious pandemic infection with different clinical features [ 2 ]. It is shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can involve respiratory tract and patients with previous cardiovascular disorders are at a higher risk [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic and electrocardiographic findings in COVID-19 patients: a cross-sectional study

Keihanian

Poorzand

Saeidinia

et al. 2022

Int J Cardiovasc Imaging

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There are still many gaps in our knowledge regarding the direct cardiovascular injuries due to COVID-19 infection. In this study, we tried to find out the effect of SARS-CoV-2 infection on cardiac function in patients without any history of structural heart disease by electrocardiographic and echocardiographic evaluations. This was a cross-sectional study on patients with COVID-19 infection admitted to Imam Reza hospital, Mashhad, Iran between 14 April and 21 September 2020. COVID-19 infection was verified by a positive reverse-transcriptase polymerase chain reaction (PCR) assay for SARS-CoV-2 using nasopharyngeal/oropharyngeal samples. We enrolled all patients over 18 years old with definite diagnosis of COVID-19 infection. All patients underwent a comprehensive transthoracic echocardiography at the first week of admission. Clinical and imaging data were collected prospectively. In total, 142 patients were enrolled in this study. The mean age of participants was 60.69 ± 15.70 years (range: 30–90 years). Most patients were male (82, 57.7%). Multivariate analysis showed that O2 saturation at admission was independently a predictor of re-hospitalization (P < 0.001). RV size (P < 0.001), dyslipidemia (P < 0.001), ejection fraction (EF) (P < 0.001), age (P = 0.020), systolic blood pressure (P = 0.001), O2 saturation (P = 0.018) and diabetes (P = 0.025) independently predicted 30-days mortality. Echocardiography can be used for risk assessment in patients with COVID-19, especially in those with previous history of diabetes and dyslipidemia. The infection could result in ventricular dysfunction, even in those without previous history of structural heart disease.

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“…Dhamad and Rhida [16] conducted a review of molecular and serological methods for the detection of COVID-19. Keihanian and Bigdelu [17] conducted a comprehensive review of cardiovascular disorders and their complications from exposure to COVID-19. The INRIA group of COVID- 19 [18] evaluates the initial needs of the COVID-19 service unit at the hospital, such as the need for a bed in the ICU unit not to be displaced even though the number is booming due to the COVID-19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

Morphological characteristics of X-ray thorax images of COVID-19 patients using the Bradley thresholding segmentation

Supriyanti

Alqaaf

Ramadhani

et al. 2021

IJEECS

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The coronavirus disease 2019 (COVID-19) pandemic has made test screening much needed. Currently, the most commonly used is the swab type. Although in fact, there is also a screening method with chest radiology. The purpose of this study is to develop a COVID-19 early detection system based on X-ray images of the patient's thorax in the form of a computer-aided diagnosis. This case is based on the fact that X-ray modalities are available in several health care centers in Indonesia, compared to other modalities such as computed tomography (CT) scan or magnetic resonance imaging (MRI). In this paper, we emphasize the X-ray thorax image segmentation process to explore the morphological information of the thorax. We use the Bradley thresholding segmentation method. The results obtained are promising to be further developed with a performance percentage of 73.33% for the thorax for COVID-19 patients and 54% for the thorax for normal patients.

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<p>Cardiovascular Considerations in COVID19: A Comprehensive Review</p>

Cited by 10 publications

References 72 publications

The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo

The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo

Echocardiographic and electrocardiographic findings in COVID-19 patients: a cross-sectional study

Morphological characteristics of X-ray thorax images of COVID-19 patients using the Bradley thresholding segmentation

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