&lt;p&gt;Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016&lt;/p&gt;

Andersen, Vibeke; Möller, Sören; Jensen, Peter Bjødstrup; Møller, Frederik Trier; Green, Anders

doi:10.2147/clep.s229056

Cited by 66 publications

(44 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 47 , 48 A study of a Danish register-based cohort reported CS babies to have increased susceptibility for chronic inflammatory diseases including diabetes, arthritis, inflammatory bowel disease, and celiac disease. 49 However, another study found no link between delivery mode and risk for celiac disease. 50 Numerous factors accompanying birth may complicate interpretation of such studies, including the use of antibiotics, dominant mode of newborn nutrition immediately after birth and maternal stress and health.…”

Section: Perinatal Microbial Encountersmentioning

confidence: 99%

The early life education of the immune system: Moms, microbes and (missed) opportunities

Jain

2020

Gut Microbes

View full text Add to dashboard Cite

The early life immune system is characterized by unique developmental milestones. Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a phenomenon referred to as 'layered' immunity. This stratified development of immune cells extends to lineages of both innate and adaptive cells. The defined time window for the development of these immune cells lends itself to the influence of specific exposures typical of the early life period. The perinatal immune system develops in a relatively sterile fetal environment but emerges into one filled with a multitude of antigenic encounters. A major burden of this comes in the form of the microbiota that is being newly established at mucosal surfaces of the newborn. Accumulating evidence suggests that early life microbial exposures, including those arising in utero, can imprint longlasting changes in the offspring's immune system and determine disease risk throughout life. In this review, I highlight unique features of early life immunity and explore the role of intestinal bacteria in educating the developing immune system.

show abstract

Section: Perinatal Microbial Encountersmentioning

confidence: 99%

The early life education of the immune system: Moms, microbes and (missed) opportunities

Jain

2020

Gut Microbes

View full text Add to dashboard Cite

show abstract

“…The strengths and weaknesses of this cohort have been discussed previously. 15 The main strength of this observational study is the inclusion of more than 2.5 million nationwide births with complete ascertainment. The most common CIDs among children treated at hospitals in Denmark were chosen with an overall rate of CID among the parents of 8.4–9.1%.…”

Section: Discussionmentioning

confidence: 99%

Chronic Inflammatory Diseases – Diabetes Mellitus, Rheumatoid Arthritis, Coeliac Disease, Crohn’s Disease, and Ulcerative Colitis Among the Offspring of Affected Parents: A Danish Population-Based Registry Study

Andersen¹,

Pedersen²,

Möller³

et al. 2021

CLEP

Self Cite

View full text Add to dashboard Cite

Background: Chronic inflammatory diseases (CIDs) may share aetiological factors across diseases. We used registry data to evaluate the risk of developing five common childhood CIDs dependent on the parents' disease status. Methods: We performed a national population-based registry study by linking data from the national Danish health registers from January 1973 to March 2016 to evaluate any potential associations between parents' disease and development of CIDs among the offspring. Results were adjusted for parental age at birth, the decade of birth, gender of the child, and type of birth. A cohort of 2,699,449 liveborn children was established for investigating the primary outcome measures: diabetes mellitus (DM), rheumatoid arthritis (RA), coeliac disease, Crohn's disease (CD), and ulcerative colitis (UC) and all diseases combined (CID). Results: Children with one CID affected parent (Hazard ratio (HR), 95% confidence interval (95% CI)=1.75 (1.72-1.79, p<0.001)), one multiple CID affected parent (HR=2.23 (2.11-2.34), p<0.001), and both parents affected (HR=3.10 (2.98-3.22), p<0.001) were at higher risk than children without CID affected parents. Children with DM, RA, and COE affected parents were at increased risk of three specific diseases (DM, RA and COE), whereas children with CD and UC affected parents were at increased risk of two specific diseases (CD and UC). Conclusion:Children with CID affected parents were at increased risk of the same CID as their parents as well as other specific CIDs dependent on the parents' CID. Future studies should address the aetiology underlying these findings to support the development of new strategies for prevention, treatment, and cure.

show abstract

“…In a very interesting proof of concept study, Korpela and co-authors [ 70 ] showed the potential beneficial effects of maternal fecal transplant (MFT) on the gut microbial development of infants born by cesarean section (CS). Interestingly, they showed that the intestinal microbiota of CS children seems to be associated with a potential increased risk of developing inflammatory diseases [ 71 ]. The application of MFT to CS-born infants was shown to restore a microbiome development very similar to what is observed in vaginally born infants.…”

Section: Limitations and Functional Perspectivesmentioning

confidence: 99%

Circulating 16S RNA in Biofluids: Extracellular Vesicles as Mirrors of Human Microbiome?

Ricci

Carcione

Messina

et al. 2020

IJMS

View full text Add to dashboard Cite

The human body is inhabited by around 1013 microbes composing a multicomplex system, termed microbiota, which is strongly involved in the regulation and maintenance of homeostasis. Perturbations in microbiota composition can lead to dysbiosis, which has been associated with several human pathologies. The gold-standard method to explore microbial composition is next-generation sequencing, which involves the analysis of 16S rRNA, an indicator of the presence of specific microorganisms and the principal tool used in bacterial taxonomic classification. Indeed, the development of 16S RNA sequencing allows us to explore microbial composition in several environments and human body districts and fluids, since it has been detected in “germ-free” environments such as blood, plasma, and urine of diseased and healthy subjects. Recently, prokaryotes showed to generate extracellular vesicles, which are known to be responsible for shuttling different intracellular components such as proteins and nucleic acids (including 16S molecules) by protecting their cargo from degradation. These vesicles can be found in several human biofluids and can be exploited as tools for bacterial detection and identification. In this review, we examine the complex link between circulating 16S RNA molecules and bacteria-derived vesicles.

show abstract

<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Cited by 66 publications

References 39 publications

The early life education of the immune system: Moms, microbes and (missed) opportunities

The early life education of the immune system: Moms, microbes and (missed) opportunities

Chronic Inflammatory Diseases – Diabetes Mellitus, Rheumatoid Arthritis, Coeliac Disease, Crohn’s Disease, and Ulcerative Colitis Among the Offspring of Affected Parents: A Danish Population-Based Registry Study

Circulating 16S RNA in Biofluids: Extracellular Vesicles as Mirrors of Human Microbiome?

Contact Info

Product

Resources

About