&lt;p&gt;c-MYC expression in T (III/IV) stage oral squamous cell carcinoma (OSCC) patients&lt;/p&gt;

Lin, Shu-Hui; Wang, Hsin‐Kai; Yeh, Kun‐Tu; Tai, Hui-Chun; Wang, Hui-Yi; Huang, Lan-Ru; Chiu, Chun-Wen; Chung, Chia Min; Velmurugan, Bharath Kumar

doi:10.2147/cmar.s201943

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…In addition, younger OSCC patients (less than 60 years old) with high TIME scores showed better survival rates, and OSCC stage III/IV patients also exhibited the same results. Previous studies have shown that male patients do not appear to benefit from immunotherapy compared with female patients (Lin et al, 2019;. However, our study revealed that male patients with high TIME scores had remarkably higher survival rates than female patients.…”

Section: Discussioncontrasting

confidence: 67%

Comprehensive Analysis of Tumor Immune Microenvironment Characteristics for the Prognostic Prediction and Immunotherapy of Oral Squamous Cell Carcinoma

et al. 2022

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Background: Oral squamous cell carcinoma (OSCC) is the most common cancer of oral and maxillofacial region. A recent clinical research has shown that tumor immune microenvironment (TIME)cells are closely related to immunotherapy sensitivity and OSCC prognosis. Nonetheless, a comprehensive analysis of TIME in OSCC has not been reported.Methods: Bioinformatics and computational algorithms were employed to determine the significance of TIME cells in 257 OSCC patients. TIME scores were measured by three TIME models, and then used to evaluate the prognosis of OSCC patients.Results: High TIME score was characterized by better prognosis in OSCC patients less than 60 years old, overexpression of immunotherapy targets (e.g., PD-1 and CLTA-4), and higher T-cell activity to inhibit tumor growth. Besides, poor prognosis was associated with low time score.Conclusion: TIME score exhibited potential as a prognostic biomarker and an indicator in predict immunotherapeutic outcomes. Through the understanding of TIME model, this study can provide a better scheme for immunotherapy as the effective treatment of OSCC patients in the future.

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Section: Discussioncontrasting

confidence: 67%

Comprehensive Analysis of Tumor Immune Microenvironment Characteristics for the Prognostic Prediction and Immunotherapy of Oral Squamous Cell Carcinoma

et al. 2022

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“…The overexpression of the MYC gene has also been noted in most patients with oral cancer. For patients with T3 or T4 oral cancer, MYC gene expression is related to the likelihood of survival and can serve as a key biomarker for treatment [37].…”

Section: Discussionmentioning

confidence: 99%

Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model

Huang

Hsieh

et al. 2020

IJMS

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Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer. Tumors are heterogeneous, with different clusters of cells expressing different genes and exhibiting different behaviors. 4-nitroquinoline 1-oxide (4-NQO) and arecoline were used to induce oral cancer in mice, and the main factors for gene expression influencing carcinogenesis were identified through single-cell RNA sequencing analysis. Male C57BL/6J mice were divided into two groups: a control group (receiving normal drinking water) and treatment group (receiving drinking water containing 4-NQO (200 mg/L) and arecoline (500 mg/L)) to induce the malignant development of oral cancer. Mice were sacrificed at 8, 16, 20, and 29 weeks. Except for mice sacrificed at 8 weeks, all mice were treated for 16 weeks and then either sacrificed or given normal drinking water for the remaining weeks. Tongue lesions were excised, and all cells obtained from mice in the 29- and 16-week treatment groups were clustered into 17 groups by using the Louvain algorithm. Cells in subtypes 7 (stem cells) and 9 (keratinocytes) were analyzed through gene set enrichment analysis. Results indicated that their genes were associated with the MYC_targets_v1 pathway, and this finding was confirmed by the presence of cisplatin-resistant nasopharyngeal carcinoma cell lines. These cell subtype biomarkers can be applied for the detection of patients with precancerous lesions, the identification of high-risk populations, and as a treatment target.

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“…Myc, a multifunctional transcription factor, regulates many genes involved in multiple biological processes such as cell growth, proliferation and apoptosis. Moreover, it promotes invasion events by activating MEK–ERK pathways [ 6 , 7 , 8 ]. It is well-known that c-Myc is expressed in many different types of cancer, including HNSCCs, in which c-Myc overexpression is responsible for poor tumor prognosis as well as the self-renewal of tumor stem cells [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

et al. 2022

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Oral squamous cell carcinoma (OSCC) represents 90% of malignant epithelial cancer that occurs in the oral cavity. The c-Myc factor is expressed in multiple types of cancer, comprising head and neck squamous cell carcinoma (HNSCC), where it plays a fundamental role in tumor prognosis and in the self-renewal of tumor stem cells. However, the role of c-Myc in controlling OSCC cells is not well-known. The aim of the present study is the evaluation of the biological roles and regulatory mechanism of c-Myc in the pathogenesis of OSCC. Results indicated that c-Myc, c-Jun, Bcl-2, hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), ERK 1/2 and pERK1/2 were overexpressed in a cellular model of squamous cell carcinoma, Cal-27. Doxorubicin (Doxo), a common chemotherapeutic agent, inhibited cell invasion, hypoxia, angiogenesis and inflammation in a cellular model of Cal-27 cells as indicated by downregulation of MMP-9, VEGF, ERK 1/2 and pERK 1/2 as well as promoted apoptosis as evidenced by the downregulation of Bcl-2 protein. This work aimed at underlying the functional relevance of c-Myc in OSCC and the HIF-Myc collaboration by integrating the knowledge on this molecular link in an OSCC tumor microenvironment. The results obtained showed for the first time the vital role of c-Myc in Cal-27 in cell survival/proliferation and tumor growth as well as the negative regulatory effect of Doxo against c-Myc signaling pathway.

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<p>c-MYC expression in T (III/IV) stage oral squamous cell carcinoma (OSCC) patients</p>

Cited by 11 publications

References 21 publications

Comprehensive Analysis of Tumor Immune Microenvironment Characteristics for the Prognostic Prediction and Immunotherapy of Oral Squamous Cell Carcinoma

Comprehensive Analysis of Tumor Immune Microenvironment Characteristics for the Prognostic Prediction and Immunotherapy of Oral Squamous Cell Carcinoma

Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model

C-Myc Expression in Oral Squamous Cell Carcinoma: Molecular Mechanisms in Cell Survival and Cancer Progression

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