&lt;p&gt;Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012&lt;/p&gt;

Chen, Ming-Fong; Hu, Yin-Lan; Wang, Yahui; Chen, Cheng‐Hsin; Lai, Chih‐Cheng; Huang, Kunlun

doi:10.2147/idr.s213845

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…At the initiation of our study, we observed most of our patients suffering from active PTB being de cient in vitamin D with average value at 14.2 ± 8.7ng/ml (Normal:25-80 ng/ml). This is in agreement with similar studies across the globe; a study in US adults acknowledged the inverse relationship of vitamin D levels with the risk of latent TB infection (LTBI) (7) and another in Sudan connected low vitamin D Levels with increased risk of PTB (8). In view of its anti-in ammatory and anti-microbial qualities as elucidated by Coussens et al, one can make the assumption for Vitamin D de ciency to be a risk factor for the development of PTB.…”

Section: Discussionsupporting

confidence: 90%

Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial

Sinha

Thukral

Shareef

et al. 2022

Preprint

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Background: The immunomodulatory effects of vitamin D are widely recognized and a few studies have been conducted to determine its utility in the treatment of tuberculosis, with mixed results. This study was conducted to see if vitamin D supplementation in patients with active pulmonary tuberculosis (PTB) in the Indian population contributed to sputum smear and culture conversion as well as the prevention of relapse.Methods: This randomized double-blind placebo-controlled trial was conducted in three sites in India. HIV negative participants aged 15-60 years with sputum smear positive PTB were recruited according to the Revised National Tuberculosis Control Program guidelines and were randomly assigned (1:1) to receive standard anti-tubercular treatment (ATT) with either supplemental dose of oral vitamin D3 (60,000 IU/sachet weekly for first two months, fortnightly for next four months followed by monthly for the next 18 months) or placebo with same schedule. The primary outcome was relapse of PTB and secondary outcomes were time to conversion of sputum smear and sputum culture.Results: A total of 846 subjects were enrolled between February 1, 2017 to February 27, 2021, and randomly assigned to receive either 60,000 IU vitamin D3 (n = 424) or placebo (n = 422) along with standard ATT. Among the 697 who were cured of PTB, relapse occurred in 14 participants from the vitamin D group and 19 participants from the placebo group (hazard risk ratio 0.68, 95%CI 0.34 to 1.37, log rank p value 0.29). Similarly, no statistically significant difference was seen in time to sputum smear and sputum culture conversion between both groups. Five patients died each in vitamin D and placebo groups, but none of the deaths were attributable to the study intervention. Serum levels of vitamin D were significantly raised in the vitamin D group as compared to the placebo group, with other blood parameters not showing any significant difference between groups.Conclusions: The study reveals that vitamin D supplementation does not seem to have any beneficial effect in the treatment of PTB in terms to the prevention of relapse and time to sputum smear and culture conversion.Trial registration: The trial protocol was registered with the ICMR, Clinical Trial Registry – India Trial registration number: CTRI/2021/02/030977 ( date of first registration-03/02/2021).

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Section: Discussionsupporting

confidence: 90%

Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial

Sinha

Thukral

Shareef

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…If the concentration of Ca 2+ in cells does not increase, Mycobacterium tuberculosis resides in phagosomes are not lysed, thereby resulting in LTBI [ 31 ]. LTBI patients may develop TB in the near or distant future [ 32 ]. Several case–control studies have linked vitamin D deficiency to active disease, although their interpretation is complicated by potential reverse causality [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis

et al. 2022

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Objective Latent tuberculosis infection (LTBI) may be a risk of developing tuberculosis (TB) and thus a health hazard. The aim of this meta-analysis is to explore the association between vitamin D and LTBI. Methods Databases including PubMed, Embase, Scopus, and ProQuest were electronically searched to identify observational or interventional studies that reported the association between vitamin D and LTBI. The retrieval time is limited from inception to 30 September 2021. Two reviewers independently screened literature, extracted data, and assessed risk bias of included studies. Meta-analysis was performed by using STATA 12.0 software. Results A total of 5 studies involving 2 case–control studies and 3 cohort studies were included. The meta-analysis result showed that the risk of LTBI among individuals was not associated with high vitamin D level (OR 0.51, 95% CI 0.05–5.65, P = 0.58). The result from cohort studies also suggested that relatively high vitamin D level was not a protective factor for LTBI (RR = 0.56, 95%CI 0.19–1.67, P = 0.300). Conclusions Our meta-analysis suggested that serum vitamin D levels were not associated with incidence of LTBI, and relatively high serum vitamin D level was not a protective factor for LTBI. Further RCTs are needed to verify whether sufficient vitamin D levels and vitamin D supplementation reduces the risk of LTBI.

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“…Several studies have provided evidence that vitamin D deficiency is a risk factor for active TB disease 13 – 16 . A few other studies have reported low vitamin D levels in latent TB individuals compared to their controls 17 , 18 . Furthermore, studies have found that TB patients have lower vitamin D levels than other contacts from the same population 4 , 19 , 20 .…”

Section: Introductionmentioning

confidence: 94%

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda

Acen

Andia-Biraro

Bbuye

et al. 2022

Sci Rep

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An estimated one billion people globally live with hypovitaminosis D. Studies have indicated that vitamin D deficiency is a risk factor for active tuberculosis (TB) disease. The aim of this study was to determine the association between vitamin D deficiency and TB status among patients with active TB, latent TB infection (LTBI) and those without TB infection. In a cross-sectional study of active TB patients, LTBI, QuantiFERON GOLD testpositive and (QFN+TST+) household contact and controls QuantiFERON GOLD testnegative (QFN−TST−) samples vitamin D levels were compared. Vitamin D status was determined by measurement of total vitamin D levels with 56 samples of active TB patients, 17 with LTBI, and 22 without TB infection using electrochemiluminescence. The median interquartile range (IQR) age of the study participants was 28 (20–35) years, and the majority (63%) were females. The median (IQR) vitamin D levels were 18 ng/ml (14–24). All groups had vitamin D hypovitaminosis with significantly lower levels among active TB patients (17 ng/ml, 13, 2) than among LTBI individuals (23 ng/ml 16–29) and those without TB infection (22 ng/ml, 17–28).

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<p>Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012</p>

Cited by 14 publications

References 31 publications

Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial

Prevention of relapse in Drug Sensitive Pulmonary Tuberculosis patients with and without Vitamin D3 supplementation: A double blinded randomized control clinical trial

Vitamin D and the risk of latent tuberculosis infection: a systematic review and meta-analysis

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda

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