<p>Association between inflammation-based prognostic scores and in-hospital outcomes in elderly patients with acute myocardial infarction</p>

Abstract

Objective Emerging evidence suggests that systemic inflammation is a predictor of poor prognosis in acute myocardial infarction (AMI). In this study, we sought to assess whether inflammation-based prognostic scores are associated with in-hospital outcomes in elderly patients with AMI. Methods In this retrospective study, patients who were over 75-years-old and met the diagnostic criteria for AMI were consecutively recruited from January 1, 2016, to March 31, 2019. Logistic regression and receiver-operating characteristic (ROC) analyses were performed to evaluate the predictive value of the inflammation-based Glasgow Prognostic Score (GPS), Prognostic Index (PI) and Prognostic Nutritional Index (PNI). Results A total of 273 patients were enrolled. The incidence of major cardiovascular adverse events (MACEs) and mortality during hospitalization increased significantly with increasing GPS and PI scores. Multiple logistic regression showed that the GPS was independently associated with MACEs (score 1, RR: 6.711, 95% CI: 1.409–31.968; score 2, RR: 14.063, 95% CI: 3.018–65.535) and mortality (score 1, RR: 8.656, 95% CI: 1.068–70.126; score 2, RR: 10.549, 95% CI: 1.317–84.465). The PI was also independently predictive of MACEs (score 2, RR: 5.132, 95% CI: 1.451–18.148). No significant difference was observed in the PNI between patients with different in-hospital outcomes. When in-hospital MACEs were used as an endpoint, the area under the curve (AUC) of the GPS was 0.740 (95% CI 0.678–0.802), and the AUC of the PI was 0.703 (95% CI 0.634–0.773). When mortality was used as an endpoint, the AUC of the GPS was 0.677 (95% CI 0.602–0.753), and the AUC of the PI was 0.667 (95% CI 0.577–0.757). Conclusion The severity of systemic inflammation is a strong predictor of poor prognosis in elderly patients with AMI. Among these three inflammation-based prognostic scores, the GPS has a better predictive value than the PI and PNI for in-hospital MACEs and mortality.

Systemic immune-inflammation index independently predicts poor survival of older adults with hip fracture: a prospective cohort study

“…Recently, the relationship between inflammation and prognosis has attracted more attention in older adults [ 35 , 36 ]. Bermejo-Bescós et al [ 14 ] found that peripheral IL-6 level was significantly associated with a higher risk of 1-year mortality after hip fracture in patients over 80 years.…”

Predictive value of three Inflammation-based Glasgow Prognostic Scores for major cardiovascular adverse events in patients with acute myocardial infarction during hospitalization: a retrospective study

“…The GPS first proposed by Forrest et al (2003) was found to be able to predict the survival time of patients with non-small cell lung cancer. Recent studies suggested that it has predictive value for the survival time of STEMI patients undergoing PPCI (Jia et al, 2018;Wang et al, 2019). The MGPS based on the GPS highlights the importance of CRP.…”

Predictors of short- and long-term mortality among acutely admitted older patients: role of inflammation and frailty

“…Therefore, alternative biomarkers easily obtainable in clinical practice should be identified and tested for mortality prediction. The Glasgow Prognostic Score (GPS), a simple tool derived from the combination of C-reactive protein and albumin levels [17], has been developed and validated to predict mortality in cancer patients and in conditions characterized by inflammation and/or malnutrition including COPD, relapse of idiopathic pulmonary fibrosis and myocardial infarction in the elderly [18][19][20][21].…”