<p>Association Between Cognitive Impairment and Blood Pressure Among Patients with Type II Diabetes Mellitus in Southern Iran</p>

Abstract

Purpose: Both type 2 diabetes mellitus (T2DM) and hypertension are regarded as lifethreatening diseases known to be risk factors for vascular diseases. They may be associated with the increased risk of cognitive impairment (CI), although there are conflicting data relating hypertension to the risk of CI. Therefore, this study aimed to explore the probable association between hypertension and CI in patients with T2DM. Patients and Methods: This cross-sectional study assessed the degree of CI of a total of 350 patients with T2DM using the Mini-Mental State Examination (MMSE). In clinical examinations, the mean of the first, second, and third measurements of systolic and diastolic blood pressure (SBP and DBP) was recorded. Results: The mean of subjects' MMSE scores was 25.48 ± 3.73. Additionally, the means of SBPSs and DBPs were found to be 118.50 ± 17.27 and 73.47 ± 10.25 mmHg, respectively. The Spearman correlation coefficient showed a mild, significant, negative correlation between MMSE scores and those of SBP (r = −0.199, p <0.001) and DBP (r = −0.233, p <0.001). Accordingly, a 1-unit increase in one's SBP would lead to a significant rise in mild CI (2.8%) in comparison with subjects who have normal CIs. However, it was shown that if one's DBP increased by 1 unit, the odds of mild CI occurring would increase significantly by 6.7% compared with those who have normal CIs. Conclusion: The present findings revealed that hypertension might be related to the development of CI in people with a diabetic condition, thus emphasizing the fact that the prevention and treatment of these highly prevalent diseases assume the utmost significance.

Factors Associated with Cognitive Impairment in Elderly Diabetic Patients in Lagos University Teaching Hospital, Lagos

“…Participants who knew their hypertensive status were less likely to develop cognitive impairment when compared to their counterparts in the study who do not know their hypertensive status. An Iranian study by similar, to our finding demonstrated an Open Access Journal of Gerontology & Geriatric Medicine association between hypertension and cognitive impairment [50]. Participants who knew their hypertensive status are more likely to take medication for blood pressure control and ameliorate the effect of hypertension in the development of cognitive impairment.…”

Cognitive impairment in older adults with DM and HBP in a primary care setting

“…With the dysfunction of flow autoregulation, it is postulated that the elimination of potentially harmful proteins such as beta-amyloid is limited, which it is worth mentioning has been found in higher concentrations in these patients. In addition, evidence of structural changes in neuroimaging associated with the increase in systolic blood pressure has been found, with a lower cerebral volume in these patients 11,33 .…”

Prevalence and Factors Associated With Cognitive Impairment Among Older People Living In Old Folk Homes, Malaysia

“…The findings were not consistent with previous study (12) due to the different geographical locations and characteristics of the study participants. Despite chronic diseases such as hypertension and diabetes mellitus type II were reported to be associated factors for the development of cognitive impairment (18), it was found that there was no significant association between chronic disease and cognitive impairment.…”