“…9 Besides, evidences have been reported that ARHGAP4 inhibits cell motility and axon outgrowth, 10 associates with nephrogenic diabetes insipidus and intellectual disability, 11 correlates with pathological stages, vascular invasion and prognosis of pancreatic cancer patients, and regulates glycolysis, invasion and migration in pancreatic cancer. 12,13 Nevertheless, the regulation of ARHGAP4 in pancreatic cancer is still undiscovered microRNAs (miRNA) are small endogenous non-coding RNA molecules with a length of about 18-25 nucleotides that repress protein translation through binding to the 3ʹ-untranlated region (UTR) of their target mRNA and are significantly involved in various cancers, including pancreatic cancer. [14][15][16] High expression of miR-196a, miR-27a, miR-221, miR-143, miR-135b, miR-199b-5p and miR-21, but low expression of miR-744, miR-455-3p and miR-655, in pancreatic cancer samples were found compared with normal samples and associated with poor prognosis.…”