&lt;p&gt;Application of Computer-Aided Design (CAD) and Three-Dimensional (3D) Visualization Technologies in the Diagnosis and Treatment of Refractory Thyroid Tumors&lt;/p&gt;

Chen, Yibo; Wang, Zhaohui; Fu, Guiming; Wan, Quan-Xin; Li, Xiaojing; Jin, Chen

doi:10.2147/cmar.s246576

Cited by 5 publications

(9 citation statements)

References 9 publications

(8 reference statements)

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“…Overall, 656 patients were included in the current systematic review. Gender of patients treated by (C)TRA was detailed in 18 papers ( 26 , 34 , 35 , 38 , 40 , 41 , 43 , 46 , 50 – 53 , 55 , 57 , 58 , 62 , 64 , 66 ) for a total of 355 patients, of whom 59% were females.…”

Section: Resultsmentioning

confidence: 99%

“…Age of patients was reported in 12 manuscripts ( 26 , 34 , 39 – 41 , 50 – 53 , 57 , 64 , 66 ) for a total of 121 patients, with a mean of 60 years (range, 20-85).…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen manuscripts reported data on (C)TRA for DTC alone ( 3 , 33 , 34 , 38 , 40 , 41 , 43 – 45 , 53 , 58 – 63 , 66 ), while 20 for mixed histologies ( 26 , 35 – 37 , 39 , 42 , 46 – 52 , 54 – 57 , 64 , 65 , 67 ). Overall, the distribution of histopathological types in patients treated by (C)TRA was detailed for 376 of them (59%) and their frequency in descending order was as follows: papillary (79%), follicular (7%), poorly differentiated (5%), medullary (2%), Hürtle cell (2%), anaplastic (1%), follicular variant of papillary cancer (1%), metastasis to the thyroid gland from other organs (1%), and rare histotypes such as thyroid squamous cell carcinoma, giant cell carcinoma, and carcinoma with lymphoepithelioma-like pattern (2% all together) ( 26 , 34 , 35 , 37 – 40 , 42 , 44 – 47 , 49 – 53 , 55 , 57 , 62 , 64 , 66 ).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, shaving for TC with deeper airway involvement, where R0 resection cannot be achieved or confirmed by frozen sections of cartilaginous tissues and possible microscopic penetration of the tumor into the airway submucosa via lymphatics piercing the inter-cartilaginous spaces may remain undetected, local failure with dismal outcomes have been reported in the literature (70,71). Moreover, while several series included in this systematic review related to patients treated primarily by (C)TRA reported 5-year survival figures >80% (34,41,44,45,47,48,55,57,58,(62)(63)(64)(65)(66), the complication and mortality rates are considerably higher and survival lower when the procedure is applied as a salvage operation for recurrence after more conservative initial surgery (72,73).…”

Section: Mechanisms Of Airway Invasion and Its Therapeutic Implicationsmentioning

confidence: 99%

“…follows: Shin I in 12 (8%) patients, Shin II in 35 (24%), Shin III in 39 (26%), and Shin IV in 62 (42%).Data on perioperative mortality were provided in 36 articles(3,26,(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67), for a total of 632 patients. The random effects model pooled risk of postoperative mortality was 2.0% (95% CI, 1.0-4.0%), with low heterogeneity.…”

mentioning

confidence: 99%

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Tracheal and Cricotracheal Resection With End-to-End Anastomosis for Locally Advanced Thyroid Cancer: A Systematic Review of the Literature on 656 Patients

et al. 2021

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Airway involvement by advanced thyroid carcinoma (TC) constitutes a negative prognosticator, besides being a critical clinical issue since it represents one of the most frequent causes of death in locally advanced disease. It is generally agreed that, for appropriate laryngo-tracheal patterns of invasion, (crico-)tracheal resection and primary anastomosis [(C)TRA] is the preferred surgical technique in this clinical scenario. However, the results of long-term outcomes of (C)TRA are scarce in the literature, due to the rarity of such cases. The relative paucity of data prompts careful review of the available relevant series in order to critically evaluate this surgical technique from the oncologic and functional points of view. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement on the PubMed, Scopus, and Web of Science databases. English-language surgical series published between January 1985 and August 2021, reporting data on ≥5 patients treated for TC infiltrating the airway by (C)TRA were included. Oncologic outcomes, mortality, complications, and tracheotomy-dependency rates were assessed. Pooled proportion estimates were elaborated for each end-point. Thirty-seven studies were included, encompassing a total of 656 patients. Pooled risk of perioperative mortality was 2.0%. Surgical complications were reported in 27.0% of patients, with uni- or bilateral recurrent laryngeal nerve palsy being the most common. Permanent tracheotomy was required in 4.0% of patients. Oncologic outcomes varied among different series with 5- and 10-year overall survival rates ranging from 61% to 100% and 42.1% to 78.1%, respectively. Five- and 10-year disease specific survival rates ranged from 75.8% to 90% and 54.5% to 62.9%, respectively. Therefore, locally advanced TC with airway invasion treated with (C)TRA provides acceptable oncologic outcomes associated with a low permanent tracheotomy rate. The reported incidence of complications, however, indicates the need for judicious patient selection, meticulous surgical technique, and careful postoperative management.

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Section: Resultsmentioning

confidence: 99%

“…Age of patients was reported in 12 manuscripts ( 26 , 34 , 39 – 41 , 50 – 53 , 57 , 64 , 66 ) for a total of 121 patients, with a mean of 60 years (range, 20-85).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Mechanisms Of Airway Invasion and Its Therapeutic Implicationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Tracheal and Cricotracheal Resection With End-to-End Anastomosis for Locally Advanced Thyroid Cancer: A Systematic Review of the Literature on 656 Patients

et al. 2021

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Clinicopathological characteristics of patients with carotid body tumor with cervical lymph node metastasis: A retrospective study of 10 cases and review of the literature

Yang¹,

Li²,

Zhang³

et al. 2022

Medicine

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Carotid body tumor (CBT), also known as carotid body chemoreceptor tumor or nonchromaffin paraganglioma, originates from the chemoreceptor behind the common carotid artery bifurcation in the carotid sheath. Most CBTs are benign. Malignant CBT (MCBT) is extremely rare, and cervical lymph node metastasis (CLNM) is usually regarded as a manifestation of malignant behavior. The association between CLNM, pathological features of the primary lesion, clinical manifestations, and prognosis deserves further investigation. The clinical materials of 133 patients with CBT who underwent total resection of the primary tumor and concomitant selective neck dissection (SND) from February 2002 to June 2018 in a single center were reviewed. Postoperative histopathology confirmed CLNM in 10 cases (10/133); clinical manifestations, pathological and imaging characteristics, and treatment outcome data were reviewed and analyzed. The average patient age was 50.5 years, with a female sex tendency (7/10). The mean and median follow-up periods of all cases were 6.9 years and 7 years, respectively. Nine patients (9/10) survived; one patient died of multiple systemic metastases 10 months after surgery when the tumor metastasized to the bilateral breast and other organs in an orderly manner. None of the patients had local recurrence, but postoperative residual lesions were detected by computer-aided 3-dimensional (3D) visualization computerized tomography in one (1/10). Most CBT cases with CLNM displayed adverse features, especially in patients without distant metastases. Immunohistochemically, the patient with distant metastases was negative for S-100, synaptophysin (Syn), and succinate dehydrogenase B (SDHB) expression. Most patients with CBT with CLNM have a good prognosis. Breast metastasis is an exceedingly rare manifestation of MCBT. Despite some association between clinical biological and histological malignancies in CBT with CLNM, the association seems to be vague in cases involving distant metastasis. The combination of certain immunohistochemical indicators (S-100, Syn, and SDHB) might be valuable for predicting the occurrence of distant metastasis. Computer-aided 3D visualization technology might be helpful for the diagnosis and postoperative follow-up of MCBT. Simultaneous SND can remove potentially metastatic lymph nodes and facilitate diagnosis and treatment.

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Application of 3D Visualization Technology in Preoperative Planning of Giant Goiter

Zhang¹

2023

SCSOAJ

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Background and Objectives: 3D visualization technology provides a more intuitive visual virtual reality surgical presentation for preoperative simulation planning, inhand visualization operation and accurate postoperative assessment in surgical procedures, but there is a lack of evidence to support whether this technology is more advantageous in preoperative planning of giant goiter. The aim of this study was to investigate the value of 3D visualization technology in the preoperative planning of giant goiter. Methods:The clinical data of eight patients with giant goiter admitted to the First People's Hospital of Anhui University of Technology for general surgery from October 2020 to August 2022 were retrospectively analyzed. The image data were imported into 3D visualization software (3D Slicer software) in DICOM format for 3D reconstruction to analyze the 3D positional relationship between the giant thyroid nodules and the surrounding tissues and organs, to perform preoperative simulation operations, and to develop precise surgical pathways.Results: All patients were operated according to the optimal plan selected by the simulation operation, and the actual surgical procedure conformed to the preoperative simulation plan 100%, and all of them successfully completed the total resection of giant thyroid nodules without any perioperative death and no new symptoms appeared after the operation. Conclusion:The use of 3D visualization technology in the preoperative planning of giant goiter can accurately obtain 3D anatomical information of the lesion and its adjacent tissues, select the optimal surgical path, and reduce surgical risks, which is of great clinical guidance value in guiding the preoperative precise surgical planning of giant goiter.

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<p>Application of Computer-Aided Design (CAD) and Three-Dimensional (3D) Visualization Technologies in the Diagnosis and Treatment of Refractory Thyroid Tumors</p>

Cited by 5 publications

References 9 publications

Tracheal and Cricotracheal Resection With End-to-End Anastomosis for Locally Advanced Thyroid Cancer: A Systematic Review of the Literature on 656 Patients

Tracheal and Cricotracheal Resection With End-to-End Anastomosis for Locally Advanced Thyroid Cancer: A Systematic Review of the Literature on 656 Patients

Clinicopathological characteristics of patients with carotid body tumor with cervical lymph node metastasis: A retrospective study of 10 cases and review of the literature

Application of 3D Visualization Technology in Preoperative Planning of Giant Goiter

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