&lt;p&gt;An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (&lt;em&gt;Pterocarpus marsupium&lt;/em&gt;) for Skin Brightening and Antiaging Effects&lt;/p&gt;

Majeed, Muhammed; Majeed, Shaheen; Jain, Renuka; Mundkur, Lakshmi; Rajalakshmi, H. R.; Lad, Prachi Subhash; Neupane, Prakriti

doi:10.2147/ccid.s238358

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…PTS is known to have antioxidant, anti-inflammatory and anti-aging activities [26]. Recent clinical trials have shown through dermatological assessment, instrumental analysis and image analysis that PTS can reduce skin aging and brighten skin tone [27]. However, it is not known whether PTS can prevent PM-induced keratinocyte damage.…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes

et al. 2021

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Particulate matter (PM) is the main indicator of air pollutants, and it may increase the level of reactive oxygen species (ROS) in keratinocytes, leading to skin inflammation, aging, and decreased moisturizing ability. Pterostilbene (PTS) is a dimethylated analog of resveratrol that has antioxidant effects. However, the molecular mechanisms of PTS in preventing PM-induced keratinocyte inflammation and aging have not been investigated yet. Therefore, we used PM-induced human keratinocytes to investigate the protective mechanisms of PTS. The results showed that 20 μM PTS had no toxicity to HaCaT keratinocytes and significantly reduced PM-induced intracellular ROS production. In addition, nuclear translocation of the aryl hydrocarbon receptor (AHR) was inhibited by PTS, leading to reduced expression of its downstream CYP1A1. PTS further inhibited PM-induced MAPKs, inflammation (COX-2), and aging (MMP-9) protein cascades, and rescued moisturizing (AQP-3) protein expression. We analyzed the PTS content in cells at different time points and compared the concentration required for PTS to inhibit the target proteins. Finally, we used the skin penetration assay to show that the PTS essence mainly exists in the epidermal layer and did not enter the system circulation. In conclusion, PTS could protect HaCaT keratinocytes from PM-induced damage and has the potential to become a cosmetic ingredient.

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Section: Discussionmentioning

confidence: 99%

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes

et al. 2021

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“…The skin moisturization and elasticity were improved with no adverse effects [109] Resveratrol in SLNs, NLCs, and nanoemulsions…”

Section: Humanmentioning

confidence: 98%

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

Lin¹,

Hung²,

Sung³

et al. 2021

Journal of Food and Drug Analysis

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Resveratrol has been extensively reported as a potential compound to treat some skin disorders, including skin cancer, photoaging, allergy, dermatitis, melanogenesis, and microbial infection. There has been an increasing interest in the discovery of cosmetic application using resveratrol as the active ingredient because of its anti-aging and skin lightening activities. The naturally occurring derivatives of resveratrol also exert a beneficial effect on the skin. There are four groups of resveratrol derivatives, including hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. The major mechanism of resveratrol and its derivatives for attenuating cutaneous neoplasia, photoaging and inflammation, are related with its antioxidative activity to scavenge hydroxyl radical, nitric oxide and superoxide anion. A systematic review was conducted to describe the association between resveratrol-related compounds and their benefits on the skin. Firstly, the chemical classification of resveratrol and its derivatives was introduced. In this review the cases which were treated for different skin conditions by resveratrol and the derivatives were also described. The use of nanocarriers for efficient resveratrol skin delivery is also introduced here. This review summarizes the cutaneous application of resveratrol and the related compounds as observed in the cell-based, animal-based and clinical models. The research data in the present study relates to the management of resveratrol for treating skin disorders and suggesting a way forward to achieve advancement in using it for cosmetic and dermatological purpose.

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“…Oral administration of grape peel extract and resveratrol exerted the anti-photoaging effects on UVB-induced skin wrinkle formation via promotion of Nrf2/HO-1 signaling cascades ( Kim et al, 2019 ). In addition, a formulation containing 0.4% pterostilbene, the resveratrol analog, extracted from the dried heartwood of Pterocarpus marsupium Roxb., showed substantial reduction of aging markers and improvement of wrinkles, skin hydration elasticity in healthy volunteers ( Majeed et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

Chaiprasongsuk

Panich

2022

Front. Pharmacol.

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Ethnopharmacological studies have become increasingly valuable in the development of botanical products and their bioactive phytochemicals as novel and effective preventive and therapeutic strategies for various diseases including skin photoaging and photodamage-related skin problems including abnormal pigmentation and inflammation. Exploring the roles of phytochemicals in mitigating ultraviolet radiation (UVR)-induced skin damage is thus of importance to offer insights into medicinal and ethnopharmacological potential for development of novel and effective photoprotective agents. UVR plays a role in the skin premature aging (or photoaging) or impaired skin integrity and function through triggering various biological responses of skin cells including apoptosis, oxidative stress, DNA damage and inflammation. In addition, melanin produced by epidermal melanocytes play a protective role against UVR-induced skin damage and therefore hyperpigmentation mediated by UV irradiation could reflect a sign of defensive response of the skin to stress. However, alteration in melanin synthesis may be implicated in skin damage, particularly in individuals with fair skin. Oxidative stress induced by UVR contributes to the process of skin aging and inflammation through the activation of related signaling pathways such as the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1), the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), the nuclear factor kappa B (NF-κB) and the signal transducer and activator of transcription (STAT) in epidermal keratinocytes and dermal fibroblasts. ROS formation induced by UVR also plays a role in regulation of melanogenesis in melanocytes via modulating MAPK, PI3K/Akt and the melanocortin 1 receptor (MC1R)-microphthalmia-associated transcription factor (MITF) signaling cascades. Additionally, nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated antioxidant defenses can affect the major signaling pathways involved in regulation of photoaging, inflammation associated with skin barrier dysfunction and melanogenesis. This review thus highlights the roles of phytochemicals potentially acting as Nrf2 inducers in improving photoaging, inflammation and hyperpigmentation via regulation of cellular homeostasis involved in skin integrity and function. Taken together, understanding the role of phytochemicals targeting Nrf2 in photoprotection could provide an insight into potential development of natural products as a promising strategy to delay skin photoaging and improve skin conditions.

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<p>An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (<em>Pterocarpus marsupium</em>) for Skin Brightening and Antiaging Effects</p>

Cited by 21 publications

References 35 publications

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes

Pterostilbene Attenuates Particulate Matter-Induced Oxidative Stress, Inflammation and Aging in Keratinocytes

The Bioactivities of Resveratrol and Its Naturally Occurring Derivatives on Skin

Role of Phytochemicals in Skin Photoprotection via Regulation of Nrf2

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