<p>Age-Related Changes in Body Composition and Bone Mineral Density and Their Relationship with the Duration of Diabetes and Glycaemic Control in Type 2 Diabetes</p>

Abstract

Purpose: To investigate age-related changes in body composition (BC) and bone mineral density (BMD) in type 2 diabetes (T2D) and analyse whether diabetes duration or glycaemic control affects these factors. Patients and Methods: We enrolled 1474 hospitalized T2D patients (817 males and 657 females; 45-85 years). BC and BMD were assessed by dual-energy X-ray absorptiometry (DEXA). Patients were stratified into age groups: 45-54, 55-64, 65-74, and ≥75 years. Continuous variables were compared using t-tests or one-way analysis of variance (ANOVA), and categorical variables were compared using chi-square tests. Effects of age, diabetes duration, and haemoglobin A 1C (HbA 1c) on BC and BMD were assessed with multiple linear regression models. Results: In T2D, in females, changes in fat mass index (FMI) were positively correlated with age, while changes in lean mass index (LMI) were unrelated to age. Changes in FMI or LMI in males were unrelated to age. For regional BC distribution, changes in visceral adipose tissue (VAT) were positively correlated with age for both males and females, while changes in appendage lean mass (ALM) were negatively correlated with age. For BMD, changes in total BMD (TBMD) in males were not correlated with age, while changes in lumbar spine BMD (LBMD) were positively correlated with age, and femoral neck BMD (FNBMD) was negatively correlated with age. Changes in BMD in all parts of females were negatively correlated with age. In addition, changes in BC and BMD were unrelated to diabetes duration, and HbA 1c was mainly associated with decreases in lean mass but had little effect on other BC and BMD parameters. Conclusion: In T2D, changes in BC and BMD were associated with age but not diabetes duration. A higher HbA 1c is associated with lower lean mass.

Association of Insulin Glargine Treatment with Bone Mineral Density in Patients with Type 2 Diabetes Mellitus

“…The BMD of all parts in female patients is negatively correlated with age. 52 BMD of femoral neck and total hip tended to decrease with age, consistent with the findings of Jiang et al, who also found that BMD at lumbar spine was not related to age. 53 , 54 …”

“…The BMD of all parts in female patients is negatively correlated with age. 52 BMD of femoral neck and total hip tended to decrease with age, consistent with the findings of Jiang et al, who also found that BMD at lumbar spine was not related to age. 53,54 In addition, it is worth mentioning that although BMD has an effect in assessing the risk of osteoporosis or fractures, but previous studies have found that BMD is not the only predictor of fracture risk.…”

Association of body composition with bone mineral density and fractures in Chinese male type 2 diabetes mellitus

“…The lean mass results are consistent with those of previous studies. In a cross-sectional study that enrolled 1474 diabetic patients aged ≥ 50 years, Tang et al [ 40 ] found that a higher HbA1c level was associated with a lower LMI. Park et al [ 19 ] found that poor glycemic control (HbA1c > 8.0%) is associated with poorer muscle quality.…”

A study of relationship between social determinant of health and imaging based age estimation using head CT

“…Biological age related markers may be incidentally collected in medical data such as physical activity from wearable devices [7][8] and medical imaging data [9][10] [11][12][13][14] [15] [16]. Age-related changes in bone density [17][18], body composition [19][20] [21], cardiovascular structures[22] [23], lungs[24] [25], and ocular structures [26] [27] have been demonstrated on imaging.…”