<p>Adult-type granulosa cell tumor of the testicle: case report</p>

Abstract

Granulosa cell tumor (GCT) is a sex-cord neoplasm of the gonads classified into either juvenile (jGrCT) or adult type (aGrCT). It is commonly arising in ovaries but is much rarer in men, with only around 50 male cases previously reported in the literature. We report on a 54-year-old male patient with a right testicular GCT measuring 10.0×8.0×6.0 cm. The tumor was treated successfully with radical orchiectomy followed by computed tomography to assess lymph node involvement, and no further treatment was done. Pathological reports showed diffuse positivity for immunohistochemical stains, inhibin, vimentin, calretinin, and CD99. The clinical and histopathological features, treatment, and prognosis of aGrCT arising in the testicle of an adult male are also reviewed in this manuscript.

Adult‐type granulosa cell tumor: An unusual testicular tumor

“…Reported cases found in the literature presented between 2 weeks to 10 years of onset swelling. Our patient is the first report with over 30 years history duration 3–5 …”

“…Retroperitoneal lymph node dissection, platinum‐based chemotherapy (e.g., Bleomycin, Etoposide, and Cisplatin), and adjuvant radiotherapy for metastatic disease. In addition, there has been a report of an advanced case of testicular granulosa cell tumor that fractionally responded to Pazopanib, an angiogenesis inhibitor after initial resistance to cytotoxic chemotherapy 5,6,8 . Radical orchidectomy was sufficient in our case as there was no evidence of local or distant metastases.…”

“…They are classified into either juvenile or adult type. The juvenile type mostly occurs in the first 6 months of life and has a benign course, whereas the adult type even though mostly benign, 10% have malignant potential 5,6 . Adult‐type granulosa cell tumor usually manifests as a painless scrotal swelling; the minority of cases may present with gynecomastia 2,7 .…”

“… 2 Less than 100 cases of adult‐type granulosa cell tumors have been reported to date of which the youngest was 12 years old of age and none of them had over 30 years history duration with reported duration varying from 2 weeks to 10 years. 3 , 4 , 5 …”

“…The juvenile type is usually benign, whereas the adult type has a clinical behavior that is difficult to predict 2 . Less than 100 cases of adult‐type granulosa cell tumors have been reported to date of which the youngest was 12 years old of age and none of them had over 30 years history duration with reported duration varying from 2 weeks to 10 years 3–5 …”