&lt;p&gt;Adherence to Option B&lt;sup&gt;+&lt;/sup&gt; Care for the Prevention of Mother-to-Child Transmission Among Pregnant Women in Ethiopia&lt;/p&gt;

Wondimu, Fikadu; Kassie, Fisseha Yetwale; Admassu, Endashew; Binu, Wakgari; Bulto, Gizachew Abdissa; Lake, Getie; Girmaye, Eden; Temesgen, Kababa; Marama, Taklu

doi:10.2147/hiv.s282463

Cited by 7 publications

(11 citation statements)

References 22 publications

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“…The sample size of included studies ranged from 103 31 to 350 14 . Six of the studies, 20,31–35 involved only HIV‐positive pregnant women whereas the remaining six studies, 13,14,19,25,36,37 included both pregnant and lactating mothers living with HIV. Adherence was measured by the self‐report method in eight studies 13,14,19,20,32–35 .…”

Section: Resultsmentioning

confidence: 99%

“…Poor ART adherence leads to a higher risk of MTCT, less effective viral suppression, increased maternal HIV/AIDS‐related morbidity and mortality, and enhances the development of drug resistance 7,15,16 . Women's adherence to ART is predicted by different factors like educational status, disclosure of HIV status, presence of social and family support, experience of drug side effects, fear of stigma, level of partner involvement, counseling, and knowledge about PMTCT 11,13,17–21 . However, the importance of these determinants varies between studies.…”

Section: Introductionmentioning

confidence: 99%

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Adherence to option B+ PMTCT program and its predictors among HIV‐positive women in Ethiopia. A systematic review and meta‐analysis

Geremew¹,

Geremew

Abdisa³

et al. 2023

Health Science Reports

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Background: Previously, few studies investigated level of adherence to option B+ lifelong antiretroviral therapy (ART) in Ethiopia. However, their findings were inconsistent. Therefore, this review aimed to determine the pooled magnitude of adherence to option B+ lifelong ART and its predictors among human immune virus (HIV)-positive women in Ethiopia.Methods: A comprehensive web-based search was conducted using PubMed, Cochrane Library, Science Direct, Google scholar, and African Journals Online databases to retrieve relevant articles. STATA 14 statistical software was used to carry out the meta-analysis. We used the random effects model to account for the large heterogeneity across included studies. Egger's regression test in conjunction with funnel plot and I 2 statistics were utilized to assess publication bias and heterogeneity among included studies respectively.Result: Twelve studies with a total of 2927 study participants were involved in this analysis. The pooled magnitude of adherence to option B+ lifelong ART was 80.72% (95% confidence interval [CI]: 77.05−84.39; I 2 = 85.4%). Disclosure of sero-status (OR 2.58 [95% CI: 1.55−4.3]), receiving counseling (OR 4.93 [95% CI: 3.21−7.57]), attending primary school and above (OR 2.45 [95% CI: 1.31−4.57]), partner support (OR 2.24 [95% CI: 1.11, 4.52]), good knowledge about prevention of mother-to-child transmission (PMTCT) (OR 4.22 [95% CI: 2.02−8.84]), taking less time to reach health facility (OR 1.64 [95% CI: 1.13−2.4]), and good relation with care provider (OR 3.24 [95% CI: 1.96−5.34]) were positively associated with adherence. Whereas, fear of stigma and discrimination (OR 0.12 [95% CI: 0.06−0.22]) and advanced disease stage (OR 0.59 [95% CI: 0.37−0.92]) were negatively associated. Conclusion:The level of adherence to option B+ lifelong ART was suboptimal.Strengthened comprehensive counseling and client education on PMTCT, HIV status disclosure, and male partner involvement are important to eliminate mother to child transmission and control the pandemic.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adherence to option B+ PMTCT program and its predictors among HIV‐positive women in Ethiopia. A systematic review and meta‐analysis

Geremew¹,

Geremew

Abdisa³

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

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“…These findings support studies showing that treatment supporters increase compliance with Option B+. [16,[21][22][23][24] A treatment supporter can be a couple, a sibling, a relative, or a friend who a mother has selected to assist. The use of treatment supporters has been a successful technique used in patients with chronic conditions that require long-term course treatment.…”

Section: Discussionmentioning

confidence: 99%

Eliminating mother-to-child transmission of HIV in Tanzania calls for efforts to address factors associated with a low confirmatory test

Morris

Nyamhagata

Tarimo

et al. 2022

Preprint

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Background Option B+ approach for prevention of mother-to-child transmission (PMTCT) has demonstrated the potential to eliminate pediatric HIV infections. Its success depends on early infant diagnosis (EID) of HIV among the exposed infants within the first 6 weeks, and a subsequent confirmatory HIV test at the 18th month. However, most mothers enrolled in the PMTCT-option B+ cascade of services in Tanzania do not turn-up for such confirmatory tests. We examined factors associated with the turning-up of mother-baby pairs on the PMTCT program for confirmatory HIV testing 18 months post-delivery in Tanzania. Methods This study utilized longitudinal data collected between 2015 and 2017 from 751 mother-baby pairs enrolled in the PMTCT- Option B+ approach in 79 health facilities from the 12 regions of Tanzania-mainland. Analysis was conducted using descriptive statistics to characterize the proportion of mother-baby pairs turning up for a confirmatory test and logistic regression analysis to examine factors associated with turning up for a confirmatory HIV testing at the 18th month. Results A total of 751 mother-baby records were observed only and 44.2% (95% CI: 40.7 – 47.8) of them received the HIV confirmatory test at 18 months. Mothers aged 25 years or above (adults’ mothers) were 1.44 more likely to turn up for confirmatory HIV-testing than young mothers; mothers with partners tested for HIV were 1.74 more likely to have confirmatory HIV-testing compared with partners not tested for HIV; newly HIV-positive mothers diagnosed on enrolment were 28% less likely to turn up their babies for confirmatory HIV-testing compared to known HIV-positive mothers; mothers with treatment supporters were 1.58 more likely to receive confirmatory HIV-testing compared to mothers without one, and mothers with babies whose DBS-PCR-1 was collected were 3.61 more likely to have confirmatory HIV-testing than those who didn’t collect DBS-PCR-1. Conclusion This study reveals that the turn-up for confirmatory HIV testing at 18 months among mother-baby pairs enrolled in the Option B+ approach is still low in Tanzania. This turn-up is associated with low maternal age, having a male partner who has not tested for HIV, lack of experience with HIV services, lack of treatment supporters, and failure to take the first DBS-PCR HIV test within the first two months post-delivery.

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“…B+ [20,[27][28][29]. A treatment supporter can be a couple, a sibling, a relative, or a friend who a mother has selected to assist.…”

Section: Plos Global Public Healthmentioning

confidence: 99%

Eliminating mother-to-child transmission of HIV in Tanzania calls for efforts to address factors associated with a low confirmatory test

Morris

Nyamhagata²,

Tarimo³

et al. 2023

PLOS Glob Public Health

View full text Add to dashboard Cite

Option B+ approach for prevention of mother-to-child transmission (PMTCT) has demonstrated the potential to eliminate pediatric HIV infections. Its success depends on early infant diagnosis (EID) of HIV among the exposed infants within the first 6 weeks, and a subsequent confirmatory HIV test within 18 months. However, most mothers enrolling in option B+ in Tanzania do not come for such confirmatory tests. We examined factors associated with the turning-up of mother-baby pairs on the PMTCT program for a confirmatory HIV testing 18 months post-delivery in Tanzania. This study utilized longitudinal data collected between 2015 and 2017, from 751 mother-baby pairs enrolled in the PMTCT-option B+ approach in 79 health facilities from the 12 regions of Tanzania-mainland. Only 44.2% of 751 mother-baby records observed received the HIV confirmatory test by the 18th month. Mothers aged 25 years or above (adults’ mothers) were 1.44 more likely to turn up for confirmatory HIV testing than young mothers; mothers with partners tested for HIV were 1.74 more likely to have confirmatory HIV testing compared with partners not tested for HIV. Newly diagnosed HIV-positive mothers were 28% less likely to bring their babies for a confirmatory HIV-testing compared to known HIV-positive mothers. Mothers with treatment supporters were 1.58 more likely to receive confirmatory HIV-testing compared to mothers without one. Mother-baby pairs who collected DBS-PCR-1 were 3.61 more likely to have confirmatory HIV-testing than those who didn’t collect DBS-PCR-1. In conclusion, the confirmatory HIV testing within 18 months among mother-baby pairs enrolled in the Option B+ approach is still low in Tanzania. This is associated with low maternal age, having a male partner not tested for HIV, lack of experience with HIV services, lack of treatment supporters, and failure to take the DBS-PCR-1 HIV test within the first two months post-delivery.

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<p>Adherence to Option B<sup>+</sup> Care for the Prevention of Mother-to-Child Transmission Among Pregnant Women in Ethiopia</p>

Cited by 7 publications

References 22 publications

Adherence to option B+ PMTCT program and its predictors among HIV‐positive women in Ethiopia. A systematic review and meta‐analysis

Adherence to option B+ PMTCT program and its predictors among HIV‐positive women in Ethiopia. A systematic review and meta‐analysis

Eliminating mother-to-child transmission of HIV in Tanzania calls for efforts to address factors associated with a low confirmatory test

Eliminating mother-to-child transmission of HIV in Tanzania calls for efforts to address factors associated with a low confirmatory test

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