&lt;p&gt;A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways&lt;/p&gt;

Sun, Chengming; Li, Guodong; Liu, Ming

doi:10.2147/ott.s256238

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…Further, miR-323-3p can inhibit the apoptosis of human lung cancer cells and inhibit the invasion and metastasis of pancreatic ductal adenocarcinoma cells [ 55 , 56 ]. Moreover, miR-507 participates in the hsa_circ_0005394/miR-507/E2F3 axis and affects the process of hepatocellular carcinoma [ 57 ]. miR-330-5p can affect the expression of ELK1 and thus affect the proliferation, migration, and invasion of colon cancer cells [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer

Tian

Yang

Zhang

et al. 2020

BioMed Research International

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Gastric cancer (GC) is one of the most common malignancies in the world, with morbidity and mortality ranking second among all cancers. Accumulating evidences indicate that circular RNAs (circRNAs) are closely correlated with tumorigenesis. However, the mechanisms of circRNAs still remain unclear. This study is aimed at determining hub genes and circRNAs and analyzing their potential biological functions in GC. Expression profiles of mRNAs and circRNAs were downloaded from the Gene Expression Omnibus (GEO) data sets of GC and paracancer tissues. Differentially expressed genes (DEGs) and differentially expressed circRNAs (DE-circRNAs) were identified. The target miRNAs of DE-circRNAs and the bidirectional interaction between target miRNAs and DEGs were predicted. Functional analysis was performed, and the protein-protein interaction (PPI) network and the circRNA-miRNA-mRNA network were established. A total of 456 DEGs and 2 DE-circRNAs were identified with 3 mRNA expression profiles and 2 circRNA expression profiles. GO analysis indicated that DEGs were mainly enriched in extracellular matrix and cell adhesion, and KEGG confirmed that DEGs were mainly associated with focal adhesion, the PI3K-Akt signaling pathway, extracellular matrix- (ECM)- receptor interaction, and gastric acid secretion. 15 hub DEGs (BGN, COL1A1, COL1A2, FBN1, FN1, SPARC, SPP1, TIMP1, UBE2C, CCNB1, CD44, CXCL8, COL3A1, COL5A2, and THBS1) were identified from the PPI network. Furthermore, the survival analysis indicate that GC patients with a high expression of the following 9 hub DEGs, namely, BGN, COL1A1, COL1A2, FBN1, FN1, SPARC, SPP1, TIMP1, and UBE2C, had significantly worse overall survival. The circRNA-miRNA-mRNA network was constructed based on 1 circRNA, 15 miRNAs, and 45 DEGs. In addition, the 45 DEGs included 5 hub DEGs. These results suggested that hub DEGs and circRNAs could be implicated in the pathogenesis and development of GC. Our findings provide novel evidence on the circRNA-miRNA-mRNA network and lay the foundation for future research of circRNAs in GC.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer

Tian

Yang

Zhang

et al. 2020

BioMed Research International

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“…Mechanistically the effect was mediated by sponging of miR-507 and miR-515-5p to increase function of E2F Transcription Factor 3 (ETF3) and C-X-C motif chemokine ligand 6 (CXCL6). 75 circ_0009582, circ_0037120 and circ_0140117 circ_0009582, circ_0037120 and circ_0140117 were found to be useful markers of HCC in tumor tissue of patients with newly diagnosed HCC. Assay in plasma verified utility of the markers.…”

Section: Circrnas Implicated In the Etiology Of Hepatocellular Carcinmentioning

confidence: 97%

“… 123 , 124 , 127 In addition, relationships of circRNAs with mechanistic effects such as those resulting from sponging of miRs provided further corroboration. 64 , 75 , 126 Assay of circRNAs in peripheral blood mononuclear cells has also been investigated as an indirect method of detecting HCC. 120 Results from this study showed that circ_0000798 was a particularly useful indicator that also correlated with patients’ prognosis.…”

Section: Circrnas Implicated In the Etiology Of Hepatocellular Carcinmentioning

confidence: 99%

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma

Ely¹,

Bloom²,

Maepa³

et al. 2021

JHC

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After being overlooked for decades, circular RNAs (circRNAs) have recently generated considerable interest. circRNAs play a role in a variety of normal and pathological biological processes, including hepatocarcinogenesis. Many circRNAs contribute to hepatocarcinogenesis through sponging of microRNAs (miRs) and disruption of cellular signaling pathways that play a part in control of cell proliferation, metastasis and apoptosis. In most cases, overexpressed circRNAs sequester miRs to cause de-repressed translation of mRNAs that encode oncogenic proteins. Conversely, low expression of circRNAs has also been described in hepatocellular carcinoma (HCC) and is associated with inhibited production of tumor suppressor proteins. Other functions of circRNAs that contribute to hepatocarcinogenesis include translation of truncated proteins and acting as adapters to regulate influence of transcription factors on target gene expression. circRNAs also affect hepatocyte transformation indirectly. For example, the molecules regulate immune surveillance of cancerous cells and influence the liver fibrosis that commonly precedes HCC. Marked over- or under-expression of circRNA expression in HCC, with correlating plasma concentrations, has diagnostic utility and assays of these RNAs are being developed as biomarkers of HCC. Although knowledge in the field has recently surged, the myriad of described effects suggests that not all may be vital to hepatocarcinogenesis. Nevertheless, investigation of the role of circRNAs is providing valuable insights that are likely to contribute to improved management of a serious and highly aggressive cancer.

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“…Sun et al. ( 35 ) demonstrate that circ_0005394 facilitates HCC growth via mediating the miR-507/E2F3 and miR-515-5p/CXCL6 axes. Jin et al.…”

Section: Role Of Circrna In Hccmentioning

confidence: 99%

“…CircRNA is highly tissue-specific and more stable than linear mRNA, making it a promising prognostic marker for HCC. Circ_0005394 is upregulated in HCC, and overexpression of circ_0005394 is linked with larger tumor size, more advanced TNM stages, and poorer survival outcome for HCC patients ( 35 ). An onco-circRNA, circMET, is identified to be an independent predictor of overall survival and postoperative recurrence in HCC patients ( 38 ).…”

Section: Clinical Significance Of Circrna In Hccmentioning

confidence: 99%

The Latest Overview of circRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

Xiong

Dang

et al. 2021

Front. Oncol.

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Hepatocellular carcinoma (HCC) is one of the main causes of tumor-related deaths worldwide. Due to the lack of obvious early symptoms and the lack of sensitive screening indicators in the early stage of HCC, the vast majority of patients are diagnosed with advanced or metastatic HCC, resulting in dissatisfactory treatment result. Therefore, it is urgent to determine effective and sensitive diagnostic and prognostic indicators and to determine new therapeutic targets. Circular RNA (circRNA) is a type of non-coding RNA that has been neglected for a long time. In recent years, it has been proved to play an important role in the development of many human diseases. Increasing evidence shows that change in circRNA expression has an extensive effect on the biological behavior of HCC. In this study, we comprehensively tracked the latest progress of circRNA in the pathogenesis of HCC, and reviewed its role as a biomarker for diagnosis and prognosis prediction in patients with HCC. In addition, we also summarized the potential of circRNA as therapeutic target in HCC and its relationship with HCC drug resistance, providing clues for the clinical development of circRNA-based therapeutic strategies.

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<p>A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways</p>

Cited by 14 publications

References 32 publications

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer

Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma

The Latest Overview of circRNA in the Progression, Diagnosis, Prognosis, Treatment, and Drug Resistance of Hepatocellular Carcinoma

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