&lt;i&gt;Zingiber officinale&lt;/i&gt;: evaulation of its Nootropic effect in mice

Joshi, Hanumanthachar; Parle, Milind

doi:10.4314/ajtcam.v3i1.31140

Cited by 30 publications

(36 citation statements)

References 24 publications

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“…While other study drug VG consists of Goghrita (Cow ghee), Vacha (Acorus calamus), Guduchi (Tinospora cordifolia), Shankhapushpi (Convolvulus pluricaulis), Haritaki (Terminalia chebula), Shati (Hedychium spicatum), Vidang (Embelia ribes), Shunthi (Z. officinale), and Apamarg (Achyranthes aspera). Eight herbal drugs of VG have been reported for their antipsychotic, antistress, antidepressant, and nootropic activities [25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of Therapeutic Potential of Vachadi and Hingwadi Ghtrita in Patients of Depression

Madhuri¹,

Asmita²

2017

Asian J Pharm Clin Res

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Objective: This exploratory clinical study dealt with comparative assessment of therapeutic effect of medicated ghee formulations, i.e., Vachadi Ghrita (VG) and Hingwadi Ghrita (HG) in patients of mild to moderate depression. Methods:Open label non-randomized standard controlled clinical trial was carried out. Using Hamilton scale test, total 12 patients of mild to moderate depression were diagnosed and then grouped in two Groups (A and B). Patients of Group A and Group B received HG and VG along with standard antidepressants for 60 days, respectively. Pre, mid, and post HAMD scores of both group patients were recorded and compared. Data were analyzed with Friedman and Mann-Whitney statistical test.Results: Statistical analysis showed a significant gradual change in HAMD values for both study groups after 60 days of treatment (p<0.05). However, when the difference between pre-and post-treatment HAMD scores of both groups are statistically analyzed, HG demonstrated significant positive result in a reduction of HAMD scores (p=0.003, <0.05) compared to VG. Beneficial effects on patients appetite, bowel movement was seen for both group patients. Conclusion:Thus, it is concluded that along with antidepressants HG would be the better choice as an adjuvant drug than VG for patients of mild to moderate depression. More studies with the larger number should be done to validate this result.

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Section: Discussionmentioning

confidence: 99%

Comparative Assessment of Therapeutic Potential of Vachadi and Hingwadi Ghtrita in Patients of Depression

Madhuri¹,

Asmita²

2017

Asian J Pharm Clin Res

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“…On the first day of study, mice were allowed to move freely to explore the apparatus for at least 10 min. TL recorded on 1st day was acquisition (learning) and 7 th and 14 th day TL reflects the retention / consolidation (memory) for learning [15].…”

Section: Assessment Of Activity Elevated Plus-maze Test (Epm)mentioning

confidence: 99%

“…The ability of mice to leave the tube within 1min was considered to indicate the lack of neurotoxic properties of the test drug. Screened mice were injected intraperitoneally as per the experimental design and were tested after 45min as described above [14,15].…”

Section: Neurotoxicity Testmentioning

confidence: 99%

Effect of Rosuvastatin on learning and memory in scopolamine induced amnesia in Mice

Rajangam¹,

Lavanya²

2018

Trends Med

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The present study was undertaken to investigate the effects of rosuvastatin (ROSS) on learning and memory on scopolamine (SCOP) induced amnesia in mice. Experiments were carried out on 20 adult albino mice, divided into 4 groups and the experimental animals were treated for 14 days with ROSS (10mg/kg.p.o).To induce amnesia, scopolamine 3 mg/kg ip was administered intraperitoneally. Cognitive skills of the animals were examined after the induction of amnesia by using elevated plus maze (EPM), Morris water maze (MWM). In EPM model, scopolamine received animals showed significant increase in transfer latency on day 7 and 14 when compared to control animals. Whereas piracetam and rosuvastatin received animals showed significant decrease (p<0.05) in transfer latency period when compared to scopolamine treated animals. In MWM test, rosuvastatin treatment showed significant decrease in escape latency period (p<0.05) when compared to scopolamine treated animals The results confirm that, scopolamine impaired learning and memory process in animals, whereas administration of ROSS significantly ameliorated scopolamine induced amnesia in both elevated plus maze and Morris water maze test as indicated by significant reduction (p<0.05) in transfer latency (TL) (p<0.05) and escape latency (EL) respectively, hence it can be concluded that, that rosuvastatin improves cognitive functions against scopolamine-induced amnesia in mice.

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“…The 1 st day (41 st day of the study) the mice was allowed to move freely to explore the apparatus for at least 10 min. TL recorded on 1st day was acquisition (learning) and after 24 h (42 nd day of the study) reflects the retention / consolidation (memory) for learning [5,13,14].…”

Section: Elevated Plus Mazementioning

confidence: 99%

Effect of Atorvastatin on Memory in Albino Mice

Kadali

2014

JCDR

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<i>Zingiber officinale</i>: evaulation of its Nootropic effect in mice

Cited by 30 publications

References 24 publications

Comparative Assessment of Therapeutic Potential of Vachadi and Hingwadi Ghtrita in Patients of Depression

Comparative Assessment of Therapeutic Potential of Vachadi and Hingwadi Ghtrita in Patients of Depression

Effect of Rosuvastatin on learning and memory in scopolamine induced amnesia in Mice

Effect of Atorvastatin on Memory in Albino Mice

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