<i>Uteroglobin-Related Protein 1</i><i>(UGRP1)</i> Gene Polymorphisms and Atopic Asthma in the Indian Population

Abstract

Background: The secretory protein, uteroglobin-related protein 1 (UGRP1), is mainly expressed in the lung and trachea and has recently been implicated in asthma. The –112 G to A transition in the promoter was reported to be associated with asthma in the Japanese population. However, this has not been replicated in other studies. The aim of this study was to find the association of UGRP1 gene polymorphisms with atopic asthma in the Indian population using a case-control (N_P = 165, N_C = 160) and a family-based (60 trios) design. Methods: Polymorphisms in the promoter region and the first exon and first intron of the UGRP1 gene were determined by direct sequencing. Results: The previously identified G^–112A and C²²²A polymorphisms were found to be in complete linkage disequilibrium (LD) (D′ = 1) in our population. However, no new polymorphism has been identified in this region. When G^–112A polymorphism was analyzed in the cases and controls, no significant difference was observed either at the allele (p = 0.68) or at the genotype (p = 0.83) levels. Moreover, in our family-based study, we observed no significant deviation of allelic transmission from random proportions (p = 0.41). Similarly, when we analyzed our genotypic results for serum total IgE levels, no significant association was observed, in both case-control as well as family-based designs. Conclusions: Our results suggest that the G^–112A and C²²²A polymorphisms do not play a significant role in the genetic predisposition of UGRP1 gene in atopic asthma in the Indian population.

The −112G > A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves’ disease in subsets of patients with elevated levels of immunoglobulin E

“…However, the association between this variant of SCGB3A2 and asthma was further replicated neither in Japanese (Jian et al 2003;Inoue et al 2008) nor in Caucasians (Heinzmann et al 2003;Batra et al 2005;Rigoli et al 2007). Despite an obvious lack of association with asthma, this promoter polymorphism of SCGB3A2 was shown to influence the transcription of SCGB3A2 (Niimi et al 2002) and modulate the severity of asthma (Inoue et al 2008).…”

Uteroglobin-related protein 1 gene −112G/A polymorphism and atopic asthma in Sicilian children

“…8 -10 In a white population, no association was found between the Ϫ112 G/A polymorphism of the UGRP1 gene and atopic asthma, 10 as well in Indian 8 and Japanese patients. 9 Therefore, these findings suggest that the UGRP1 gene does not play a major role in the development of bronchial asthma.…”

Association of a chromosome 1q21 locus in close proximity to a late cornified envelope-like proline-rich 1 (LELP1) gene with total serum IgE levels

“…The demographic and clinical details of the study population are given in Table 1. Genetic homogeneity between the patients and the control group was confirmed by genotyping various loci that have yet to be linked to asthma-related disorders (Batra et al 2005). Total serum IgE levels were estimated using enzyme-linked immunosorbent assay (ELISA) (Bethyl Labs, Montgomery, TX, USA).…”