<i>RET</i> gene mutational diagnosis and precision medicine in Mexico

Abstract

To date, there are several successful examples: mutations are used as molecular markers, as well as for technological development of new specific drugs or new oncogenomic taxonomies. Other examples are the study of chronic myeloid leukemia related to Philadelphia chromosome 3 and breast cancer with suppressor genes BRCA1/2. 4 A much more complex strategy than the previous ones is tumor mutational burden (TMB) test, whereby pathogenic variants are