<i>Pasteurella multocida</i> Infective Endocarditis: A Possible Link with Primary Upper Respiratory Tract Infection

Abstract

A 50-year-old Japanese man presented with fever and upper respiratory tract symptoms that required urgent inpatient admission. A physical examination revealed conjunctival hemorrhages and peripheral embolic phenomena. Blood cultures grew Pasteurella multocida, and an echocardiography revealed a mitral valve vegetation suggestive of infective endocarditis (IE), which was confirmed using the Modified Duke Criteria. After several antibiotic regimens proved ineffective, valve replacement was performed, with a good eventual outcome. P. multocida IE is rare and may sometimes have no preceding risk factors. P. multocida infections of the upper respiratory tract are unusual but may be an inciting event for IE. It is essential to check blood cultures and to repeat the performance of physical examinations to appreciate the developing features of IE.

Virus-induced genetics revealed by multidimensional precision medicine transcriptional workflow applicable to COVID-19

“…Died; clinical myocarditis and culture-negative endocarditis; clinical Staph infection; liver failure; renal failure; brain injury; respiratory failure; high mapping of Pasteurella multocida (common infection from cat scratches) and Gordonia polyisoprenivorans VH2, P. multocida has been observed to cause endocarditis as well as respiratory tract symptoms (8,64), and G. polyisoprenivorans VH2 has been observed to cause endocarditis (54); family had two cats as pets; day 3 elevated monocytes; ALB RNA detected in blood at day 0 with five additional liver genes; several pituitary associated genes elevated.…”

Pasteurella Endocarditis: A Case Report and Statistical Analysis of the Literature

“…"Cure" in the "Outcome" category is defined as complete resolution of all signs and symptoms of endocarditis. [18,19,21,24,26,27,30,31,35,37,38,43,45,46,49], 4 prosthetic aortic valves (3 bioprostheses [5,32,36] and 1 mechanical prosthetic [41]), 10 native mitral valves [2,18,22,25,28,29,33,34,47,48], 2 native tricuspid valves [42,44], 1 native pulmonary valve [39], 1 dual-infection of native mitral and tricuspid valves [23], and our dual-infection of metal aortic prosthesis and native tricuspid valve.…”

“…The number of reported cases has increased over every decade since the first recorded case. Of those countries represented more than once, Saudi Arabia has reported 2 cases [ 26 , 38 ], Japan 4 [ 29 , 34 , 47 , 48 ], France 8 [ 18 , 21 , 22 , 24 , 35 , 37 , 46 ], and the United States 13 [ 2 , 5 , 19 , 20 , 23 , 27 , 28 , 31 , 32 , 36 , 43 , 44 ]. While many patients presented with a past medical history (PMH) significant for substance abuse (7, including ethanol and nicotine abuse) [ 21 , 23 , 28 , 30 , 37 , 39 , 49 ], liver disease (8) [ 18 , 21 , 25 , 28 , 30 , 31 , 35 ], or heart disease (17) [ 2 , 5 , 18 , 20 , 25 , 27 – 29 , 31 , 32 , 34 , 36 , 40 , 41 , 44 , 45 ], other comorbidities were noted, though in 6 cases [ 19 , 24 , 26 , 38 , 46 , 47 ], there was no significant PMH presented.…”

“…Resistance to antibiotics in Pasteurella strains was scarcely described across the literature. One study each reported resistance to penicillin [ 33 ] and piperacillin-tazobactam [ 48 ] in P. multocida and to bacitracin and triacetyloleandomycin in a non- multocida species [ 2 ]. Of the remaining studies, only three explicitly stated that no resistances were identified [ 23 , 26 , 29 ], and all other studies failed to discuss resistance, making an accurate antibiogram at this time impossible.…”

Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow

“…H3-R26 citrullination is involved in increasing immune response (37); 180 transcripts increased from day0-8 (GO: immune system process). Gordonia polyisoprenivorans VH2, Pasteurella multocida has been observed to cause endocarditis as well as respiratory tract symptoms (43,44) and Gordonia polyisoprenivorans VH2 has been observed to cause endocarditis (45), family had two cats as pets; Day3 elevated monocytes; ALB RNA detected in blood at day 0 with five additional liver genes; several pituitary associated genes elevated.…”