&lt;i&gt;Lactobacillus&lt;/i&gt; attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

Lee, Na Young; Shin, Min Jea; Youn, Gi Soo; Yoon, Sang Jun; Choi, Ye Rin; Kim, Hyeong Seop; Gupta, Haripriya; Han, Sang Hak; Kim, Byoung Kook; Lee, Mi Kyung; Park, Tae Sik; Sung, Hotaik; Kim, Byung Yong; Suk, Ki Tae

doi:10.3350/cmh.2020.0125

Cited by 79 publications

(47 citation statements)

References 46 publications

(67 reference statements)

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“…In general, the majority of these studies have addressed the effects of specific probiotic strains in animals challenged by diets leading to NAFLD. In this line, the administration of several probiotic strains (mainly Lactobacillus and Bifidobacterium ) has been shown to be effective in reducing liver lipid accumulation under dietary conditions providing 40 to 65% of energy as fat [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Moreover, this effect is also maintained when excessive hepatic lipid accumulation is mediated by dietary conditions providing high sugar intakes (10 to 30% of energy as fructose).…”

Section: Effects Of Probiotic Administration (Single Strain and Mixtu...mentioning

confidence: 99%

“…There are also a number of studies that have addressed the effects induced by probiotic administration on gut microbiota composition, microbial metabolite production and intestinal barrier integrity, all processes involved in NAFLD pathogenesis. Thus, the majority of the studies have reported that single-strain probiotic administration prevented diet-induced gut microbiota dysbiosis, mainly by increasing bacterial diversity and Bacteroidetes relative abundance and/or decreasing the Firmicutes / Bacteroidetes ratio [ 16 , 18 , 20 , 24 , 25 , 29 , 31 , 37 ]. In addition, the enhanced gene and protein expression of intestinal tight-junction markers, such as Occludin-1, Zonula Occludens-1 or Claudin, suggests that single-strain probiotic administration is an effective approach preventing high-fat and/or high-sugar diets induced gut barrier function impairment [ 17 , 20 , 32 , 36 , 37 ].…”

Section: Effects Of Probiotic Administration (Single Strain and Mixtu...mentioning

confidence: 99%

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Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Arellano-García

Baquedano

Martínez

et al. 2022

IJMS

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The present review aims at analyzing the current evidence regarding probiotic administration for non-alcoholic fatty liver disease (NAFLD) management. Additionally, the involved mechanisms of action modulated by probiotic administration, as well as the eventual limitations of this therapeutic approach and potential alternatives, are discussed. Preclinical studies have demonstrated that the administration of single-strain probiotics and probiotic mixtures effectively prevents diet-induced NAFLD. In both cases, the magnitude of the described effects, as well as the involved mechanisms of action, are comparable, including reduced liver lipid accumulation (due to lipogenesis downregulation and fatty acid oxidation upregulation), recovery of gut microbiota composition and enhanced intestinal integrity. Similar results have also been reported in clinical trials, where the administration of probiotics proved to be effective in the treatment of NAFLD in patients featuring this liver condition. In this case, information regarding the mechanisms of action underlying probiotics-mediated hepatoprotective effects is scarcer (mainly due to the difficulty of liver sample collection). Since probiotics administration represents an increased risk of infection in vulnerable subjects, much attention has been paid to parabiotics and postbiotics, which seem to be effective in the management of several metabolic diseases, and thus represent a suitable alternative to probiotic usage.

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Section: Effects Of Probiotic Administration (Single Strain and Mixtu...mentioning

confidence: 99%

Section: Effects Of Probiotic Administration (Single Strain and Mixtu...mentioning

confidence: 99%

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Arellano-García

Baquedano

Martínez

et al. 2022

IJMS

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“…We observed a species-specific increase of L. reuteri with a concurrent decrease in L. murinus suggesting shifts in Lactobacillus composition at the species and/or strain levels. Further, decreased abundance of L. murinus has been reported in human NAFLD [53]. Other taxa enriched following treatment included Turicibacter sanguinis, an anaerobic grampositive bacillus commonly found in animals, including humans [54].…”

Section: Discussionmentioning

confidence: 95%

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease

Fling

Zacharewski

2021

IJMS

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Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. TCDD induces hepatic fat accumulation and increases levels of secondary bile acids, including taurolithocholic acid and deoxycholic acid (microbial modified bile acids involved in host bile acid regulation signaling pathways). To investigate the effects of TCDD on the gut microbiota, the cecum contents of male C57BL/6 mice orally gavaged with sesame oil vehicle or 0.3, 3, or 30 µg/kg TCDD were examined using shotgun metagenomic sequencing. Taxonomic analysis identified dose-dependent increases in Lactobacillus species (i.e., Lactobacillus reuteri). Increased species were also associated with dose-dependent increases in bile salt hydrolase sequences, responsible for deconjugation reactions in secondary bile acid metabolism. Increased L. reuteri levels were further associated with mevalonate-dependent isopentenyl diphosphate (IPP) biosynthesis and o-succinylbenzoate synthase, a menaquinone biosynthesis associated gene. Analysis of the gut microbiomes from cirrhosis patients identified an increased abundance of genes from the mevalonate-dependent IPP biosynthesis as well as several other menaquinone biosynthesis genes, including o-succinylbenzoate synthase. These results extend the association of lactobacilli with the AhR/intestinal axis in NAFLD progression and highlight the similarities between TCDD-elicited phenotypes in mice to human NAFLD.

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“…This supported that Lactobacillus could modulate the microbiota; therefore, microbiota modulation by probiotics is being studied as one of the mechanisms to alleviate various diseases. Lactobacillus attenuated the progression of obesity-induced non-alcoholic fatty liver disease by regulating the microbiome [72]. In addition, the vaginal microbiota of nonpregnant sexually active women with diagnoses of bacterial vaginosis receiving L. rhamnosus BMX 54 was different from that of the untreated group.…”

Section: Mode Of Action As a Probioticmentioning

confidence: 95%

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Jeong¹,

Park²,

Gi³

et al. 2022

Microorganisms

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Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about 300 species of bacteria (recently differentiated into 23 genera) and countless strains have been reported. They improved a wide range of diseases including liver disease, gastrointestinal diseases, respiratory diseases, and autoimmune diseases. Here, we intend to discuss in depth the genus Lactobacillus as a representative probiotic for chronic liver diseases.

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<i>Lactobacillus</i> attenuates progression of nonalcoholic fatty liver disease by lowering cholesterol and steatosis

Cited by 79 publications

References 46 publications

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Usefulness of Probiotics in the Management of NAFLD: Evidence and Involved Mechanisms of Action from Preclinical and Human Models

Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) Dose-Dependently Shifts the Gut Microbiome Consistent with the Progression of Non-Alcoholic Fatty Liver Disease

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

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