&lt;i&gt;In vitro&lt;/i&gt; studies on the antimicrobial, antioxidant and antidiabetic potential of &lt;i&gt;Cephalaria gigantea&lt;/i&gt;

Mbhele, N.; Balogun, Fatai Oladunni; Kazeem, Mutiu Idowu; Ashafa, Tom

doi:10.3329/bjp.v10i1.21716

Cited by 26 publications

(16 citation statements)

References 29 publications

(25 reference statements)

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“…In Nigeria and other countries, many indigenous plants are used in herbal medicine to cure various diseases and heal injuries [14]. According to WHO, 80% of the world population living in the rural areas depend on medicinal plants as primary health care system [7,[15][16][17]. Plants have been proven to be a novel source for bioactive natural products, their ethnopharmacological effects have been used as a primary source for drug discovery [18].…”

Section: Medicinal Plants In Cancer Therapymentioning

confidence: 99%

Exploring the Nigerian Medicinal Plants with Anticancer Activities: A Pharmacological Review

Abdullahi¹

2018

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Cancer has become one of the most dangerous diseases and is the leading cause of death in economically developed countries and the second leading cause of death in developing countries. Many indigenous plants are used in herbal medicine to cure various diseases and heal injuries. The use of medicinal plants has become essential due to the presence of several bioactive substances and their availability. Most chemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Anticancer agents from plants currently in clinical use are categorized into four main classes of compounds including; epipodophylltoxins, taxanes camptothecins, and vinca alkaloids. This paper discussed the factors responsible for, different forms of cancer, as well as organs or parts it affect. The paper also explored some Nigerian medicinal plants with anticancer agents. Seventeen medicinal plants were mentioned and confirmed to possess bioactive constituents responsible for cancer therapy.

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Section: Medicinal Plants In Cancer Therapymentioning

confidence: 99%

Exploring the Nigerian Medicinal Plants with Anticancer Activities: A Pharmacological Review

Abdullahi¹

2018

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“…The unregulated hydrolysis of starch by αamylase and α-glucosidase which catalyze the rate limiting step in the conversion of oligosaccharides and disaccharides into monosaccharide's is responsible for the elevated blood glucose seen in T2DM. Therefore, controlling hyperglycaemia via inhibition of carbohydrate hydrolysing enzymes is an important strategy in the management of T2DM [47][48][49] . In vitro evaluation of the inhibitory effects of the AFE on α-glucosidase and pancreatic α-amylase enzymes was carried out using acarbose as the standard to determine its percentage inhibition and their respective IC 50 value.…”

Section: In Vitro Anti-diabetic Assaysmentioning

confidence: 99%

Phytochemical Screening and in Vitro Antioxidant and Anti-Diabetic Potentials of Persea Americana Mill. (Lauraceae) Fruit Extract

Rao

2018

Univ J Pharm Res

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Diabetes mellitus (DM) is a metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction and the management of blood glucose level is an important strategy in the control of the disease and complications associated with it. Therefore, components that cause uptake of glucose from the bloodstream and inhibitors of carbohydrate hydrolyzing enzymes can be useful in treatment of DM and medicinal plants are often used to achieve this aim. Avocado fruit is rich in phytochemicals necessary for treatment of DM. The purpose of this study was to investigate the inhibitory effect of Persea americana fruit extracts on α-amylase and α-glucosidase enzymes. The percentage yield, phytochemical screening (both qualitative and quantitative), in vitro antioxidant and anti-diabeticassays, and kinetic studies were performed with different solvent extracts of Avocado fruit pulp. Results: Avocado hadgreat and promising potential as pharmaceutical agent, particularly to be developed as anti-diabetic through the inhibition of α-glucosidase and α- amylase enzymes. In vitro studies of the antioxidant activity of the fruit extract gaveanevidence and strong biochemical rationale of their therapeutic potential. The fruit extract of P. americana may play an important role in the development of nutraceuticals and also in the management of oxidative stress induced DM.

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“…36 Last study we cite here for biological activities, is comprehensive, despite the fact that it studied only C. gigiantea and did not report new compounds. 37 Finally, despite being very widespread on the eastern parts of the Mediterranean basis, Cephalaria jopponsis was never studied before. Our wide search of published literature search could not find any study about the biological/medicinal activities of this species.…”

Section: Introductionmentioning

confidence: 99%

Total Phenolic Content, Antioxidant Capacity and Antifungal Activity of Extracts of Carthamus tenuis and Cephalaria joppensis

Azab¹

2018

ECB

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Three different extracts (aqueous, ethanolic and ethyl acetate) of Carthamus tenuis and Cephalaria jopprnsis were prepared and tested for total phenolic content (TPC), antioxidant capacity and antifungal activity. Results for C. tenuis are meaningfully different of known findings. As for C. joppensis, the medicinal and biological properties of this plant were never published before. For each plant, TPC was highest in aqueous extracts and these had highest antioxidant capacity. Ethanolic extracts of both plants had strongest activity against Rhizopus stolonifer (black mold).

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<i>In vitro</i> studies on the antimicrobial, antioxidant and antidiabetic potential of <i>Cephalaria gigantea</i>

Cited by 26 publications

References 29 publications

Exploring the Nigerian Medicinal Plants with Anticancer Activities: A Pharmacological Review

Exploring the Nigerian Medicinal Plants with Anticancer Activities: A Pharmacological Review

Phytochemical Screening and in Vitro Antioxidant and Anti-Diabetic Potentials of Persea Americana Mill. (Lauraceae) Fruit Extract

Total Phenolic Content, Antioxidant Capacity and Antifungal Activity of Extracts of Carthamus tenuis and Cephalaria joppensis

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