&lt;i&gt;In vitro&lt;/i&gt; host range of feline morbillivirus

Sakaguchi, Shoichi; Koide, Rie; Miyazawa, Takayuki

doi:10.1292/jvms.15-0213

Cited by 18 publications

(29 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of FeMV in the liver of infected cats, most of which were affected by cholangiohepatitis, was already demonstrated through immunohistochemistry (Yilmaz et al, 2017). Moreover, studies in vitro demonstrated that FeMV may have tropism for several cellular lines therefore being potentially able to infect different organs (Sakaguchi et al, 2015). The cat with FeMV-positive urine had no medical requirements to perform a kidney biopsy.…”

Section: Discussionmentioning

confidence: 97%

Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease

Stranieri

Lauzi

Dallari

et al. 2019

Veterinary Microbiology

View full text Add to dashboard Cite

A B S T R A C TFeline morbillivirus (FeMV) is an emerging virus that was first described in Hong Kong in 2012. Several reports suggested the epidemiological association of FeMV infection with chronic kidney disease (CKD) in cats. The aim of this study was to investigate the presence and the genetic diversity of FeMV as well as the relationship between FeMV infection and CKD in cats from Northern Italy. Urine (n = 81) and kidney samples (n = 27) from 92 cats admitted to the Veterinary Teaching Hospital of the University of Milan between 2014 and 2017 were investigated for FeMV infection. FeMV RNA was detected in one urine sample (1.23%; 95% CI: 0.03-6.68%) and in two kidneys (7.40%; 95% CI: 0.91-24.28%). FeMV RNA was revealed only in urine or kidneys of cats without evidence of CKD. Phylogenetic analysis showed that the three strains clustered with FeMV strains retrieved from public database, forming a distinct sub-cluster of FeMV. The presence of distinct genotypes of FeMV found in this study is in accordance with previous studies demonstrating that FeMV strains are genetically diverse. A clear relationship between the presence of FeMV infection and CKD in the cats from Northern Italy was not observed, confirming recent reports that do not support the hypothesis that FeMV infection is associated with the development of CKD.

show abstract

Section: Discussionmentioning

confidence: 97%

Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease

Stranieri

Lauzi

Dallari

et al. 2019

Veterinary Microbiology

View full text Add to dashboard Cite

show abstract

“…Table 1 Molecular prevalence of FeMV sequences in cat urine or kidney tissues in published studies Table 2 Seroprevalence A single study evaluating FeMV cell tropism in vitro documented viral replication in cat fibroblasts, lymphoid cells and glial cells. 43 No other morbilliviruses have been linked to kidney disease (see box on page 8), although they can infect epithelial cells of the urogenital tract. in addition to the hypothesis that FeMV may cause kidney disease, one study has suggested a potential association with liver disease, 28 although strong evidence is lacking.…”

Section: Pathogenesismentioning

confidence: 99%

Novel feline viruses: Emerging significance of gammaherpesvirus and morbillivirus infections

Beatty

Sharp

Duprex

et al. 2018

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Practical relevance: New technologies capable of sequencing the genetic material in any given biological sample, combined with computer-based algorithms for sequence assembly and analysis, have revolutionised infectious disease research. The rate at which novel viruses are being discovered now exceeds our understanding of their clinical relevance. Novel viruses may contribute to diseases that are major causes of feline morbidity and mortality, including cancer and chronic kidney disease. The identification of new viral pathogens raises the prospect of not only improved patient outcomes through specific treatment but even disease prevention through viral control measures. Clinical challenges: It can be difficult to determine the role of a novel virus in disease development. Disease may be an occasional outcome, often years after infection. A high prevalence of infection in the general population can make disease associations harder to identify and almost impossible to rule out. Host cofactors such as immune dysfunction, genetic background or coinfections may be required for manifestation of disease, and one virus species may be linked to a range of pathological sequelae. Establishing causality relies on evaluating accumulating evidence from multiple investigations, which is often hard to access by practitioners. Global importance: The worldwide distribution of gammaherpesvirus and morbillivirus infections in domestic cats underlines the potential of these viruses to negatively impact feline health and welfare globally. Evidence base: This review relies on grade Ia-III evidence.

show abstract

“…57,58 o Morbillivirus: Several studies have raised interest in a potential association between CKD and morbillivirus infection (FmoPV), a paramyxovirus identified in cats. [59][60][61][62][63] The virus was shown to have cytopathic effects in FCRK cell lines and in small numbers of stray cats there seemed to be a higher prevalence of tubulointerstitial nephritis in the cats that were positive for the feline morbillivirus than in negative cats, although little demographic and phenotypic data was available for either group. 62 FmoPV has also been identified in the urine (10%) and blood (6%) of stray cats in a study performed in Japan, and at a higher prevalence from renal tissue (40%; 4/10) from cats with CKD.…”

Section: Association Of the Development Of Chronic Kidney Disease Witmentioning

confidence: 99%

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Jepson

2016

Veterinary Clinics of North America: Small Animal Practice

View full text Add to dashboard Cite

Abstract:In cats with chronic kidney disease (CKD), the most common histopathological finding is tubulointerstitial inflammation and fibrosis. However, these changes reflect a non-specific response of the kidney to any inciting injury. The risk of development of CKD in a patient is likely to reflect genetic predispositions, ageing, environmental and individual factors that influence decline in renal function over the course of a cat's life. However, there is still relatively little information about exactly which risk factors predispose a cat to develop CKD and these will be explored. Whilst many cats diagnosed with CKD have stable disease for many years, some cats show overtly progressive disease.

show abstract

<i>In vitro</i> host range of feline morbillivirus

Cited by 18 publications

References 19 publications

Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease

Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease

Novel feline viruses: Emerging significance of gammaherpesvirus and morbillivirus infections

Current Understanding of the Pathogenesis of Progressive Chronic Kidney Disease in Cats

Contact Info

Product

Resources

About