&lt;i&gt;In Vitro&lt;/i&gt; Degradation of β-Tricalcium Phosphate Reinforced Poly(L-Lactic Acid)

Adamus, Agnieszka; Jozwiakowska, Joanna; Wach, Radosław A.; Suarez-Sandoval, D.; Ruffieux, Kurt; Rosiak, Janusz M.

doi:10.4028/www.scientific.net/msf.714.283

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…However, this is not always the case. Namely, studies are available, in which the presence of CaPO 4 did not have an effect on the degradation rate of the polymer matrix [ 1105 , 1106 , 1107 ]. Therefore, to simplify the task, biodegradation of the individual components should be considered independently.…”

Section: Bioactivity and Biodegradationmentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

129

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Bioactivity and Biodegradationmentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

129

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“…According to various studies made on animal models, PEEK implants demonstrate good compatibility with the tissue, without any sign of necrosis. These studies demonstrate the biological properties of PEEK because at the interface between the PEEK implants and surrounding tissues didn't appear the sign of foreign body response, and the possibility of bacterial colonization is limited [39,40].…”

Section: Discussionmentioning

confidence: 88%

Bioabsorbable Anchors for Medial Patellofemoral Ligament Reconstruction

Ene

Panti

Nica

et al. 2017

KEM

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Acute dislocation of the patella is a very common injury of the knee. In more than 90% of the cases the medial patellofemoral ligament (MPFL) is injured. Reconstruction of the MPFL has become a popular soft tissue procedure, which reduces hospitalization and the rehabilitation period. Bioabsorbable materials, in form of screws and anchors are ideal for soft fixation to bones in orthopedics. We would like to present our experience and short-term results after MPFL reconstruction with semitendinous autograft and bioabsorbable fixation devices. 10 patients were involved in this study with PF joint instability, who underwent to MPFL reconstruction. In order to evaluate the functional outcome of the procedure we applied the Tegner Lysholm scoring system before and after 3 Months of surgery. MPFL reconstruction significantly improved the functionality of the PF joint. Gender distribution of the studied group was: 7 female with an average age of 25 5,03 SD and 3 male patients with an average age of 29 1 SD. The key for the success in MPFL reconstruction is the positioning of the femoral tunnel, followed by an isometric tensioning of the graft. Bioabsorbable materials reduce inflammatory, and foreign body response facilitating biointegration of the autograft.

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“…This is not always the case, though. Namely, there have been studies showing that the presence of CaPO 4 does not affect the degradation rate of polymer matrices [1252][1253][1254]. Therefore, to simplify the learning, the biodegradation of individual components needs to be considered independently.…”

Section: Bioactivity and Biodegradability Of Capo 4 -Containing Bioco...mentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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<i>In Vitro</i> Degradation of β-Tricalcium Phosphate Reinforced Poly(L-Lactic Acid)

Cited by 6 publications

References 20 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Bioabsorbable Anchors for Medial Patellofemoral Ligament Reconstruction

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

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