<i>In Vitro</i> Degradation of Electrospun Fiber Membranes of PCL/PVP Blends

Abstract

The ultrafine fibers of poly(ε-caprolactone) (PCL) composited with different Polyvinyl Pyrrolidone (PVP) content were successfully prepared by electrospinning method. The morphology, hydrophilicity and in vitro degradation behavior of samples were characterized by Scanning Electron Microscopy (SEM), water contact angle and weight loss rate. Pore size and distribution on the fibers changed with the increase of PVP content. The hydrophilicity of PCL membrane was improved by addition of PVP. When the content of PVP was 25% and 50%, the water contact angle approached zero. The degradation was essentially a dissolution process of PVP on the first 7days. Since large specific surface, high porosity and different crystallinity, percent degradation loss of electrospun fiber membranes were about 1 to 12 times higher than that of cast films.

Sabina chinensis leaf extracted and in situ incorporated polycaprolactone/polyvinylpyrrolidone electrospun microfibers for antibacterial application

“…The WCA of the microber membranes without ScLE was less than 10 , and their surfaces showed good hydrophilicity, which coincided with the high hydrophilicity of PCL bers with added PVP in a previous report. 29 When ScLE was incorporated into the spinning solution, the WCA of the PCL/PVP microbers sharply increased to about 90 . The WCA of the PCL/PVP microbers slightly increased with the increase of the ScLE proportion.…”

“…26,27 The high hydrophobicity and low biodegradation rate of PCL limit its application in the biomedical eld. 28,29 As a synthetic water-soluble polymer, polyvinylpyrrolidone (PVP) has excellent colloidal protection, lm-forming, adhesion, hygroscopicity, solubilization and coagulation properties. 30 PVP can be dissolved in both water and most organic solvents, and it displays low toxicity, good biocompatibility and appropriate viscoelastic properties, which are also rare in biopolymers.…”

“…30,31 The hydrophilicity and biodegradability of electrospun PCL micro-and nanobers are improved by incorporating PVP into PCL organic solution. 28,29,[32][33][34][35][36][37] In this study, the solution extracted from fresh leaves of Sabina chinensis by organic solvent at room temperature was directly used as the spinning solvent. PCL and PVP were directly added to the spinning solvent to prepare the spinning solution.…”

Bilayer Membrane Composed of Mineralized Collagen and Chitosan Cast Film Coated With Berberine-Loaded PCL/PVP Electrospun Nanofiber Promotes Bone Regeneration

“…These problems can be addressed by combining PCL with water-soluble polymers ( Phipps et al, 2012 ; Tiwari et al, 2017 ) such as polyvinyl alcohol ( Kim et al, 2006 ), polyethylene oxide ( Kim et al, 2007 ), and polyvinylpyrrolidone (PVP). Nanofibers electrospun from the combination of PCL and PVP have excellent solubility and biocompatibility; PVP was shown to accelerate the biodegradation and increase the hydrophilicity of PCL ( Jia et al, 2011 ; Kim et al, 2013 ; PranavKumar Shadamarshan et al, 2018 ). The osteoinductive activity of electrospun nanofibers can be enhanced by the addition of growth factors or natural small molecules.…”

Preparation and characterization of electrospun poly(ε-caprolactone)/poly(vinyl pyrrolidone) nanofiber composites containing silver particles

“…The compositions of PCL/PTMC , PCL/chitosan , PVP/chitosan , and PCL/PVA were electrospun to meet several specific functional applications . To our knowledge, only few studies electrospun the blends of PCL/PVP , including one of our previous report. This kind of composite would be used as wound dressing for its similarity of the three‐dimensional structures to native extracellular matrix, and its capacity of absorbance of wound fluid can be easily manipulated by altering the blend ratio of PCL/PVP.…”