&lt;i&gt;In vitro&lt;/i&gt; Activity and Safety Assessment of New Synthesized Thiazolo Pyrimidine Derivatives Augmented with Albendazole against &lt;i&gt;Echinococcus Multilocularis&lt;/i&gt; Metacestodes in Balb/C Mice

Bahashwan, Saleh; Alharbi, Ahmed Eid; Ramadan, Mohamed; Fayed, Ahmed A.; Bahashwan, A.

doi:10.4314/tjpr.v12i6.18

Trop. J. Pharm Res

2014

DOI: 10.4314/tjpr.v12i6.18

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<i>In vitro</i> Activity and Safety Assessment of New Synthesized Thiazolo Pyrimidine Derivatives Augmented with Albendazole against <i>Echinococcus Multilocularis</i> Metacestodes in Balb/C Mice

Saleh Bahashwan¹,

Ahmed Eid Alharbi²,

Mohamed Ramadan³

et al.

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Cited by 3 publications

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“…It should be mentioned that in the few existing reports on the synthesis of 2,4-(oxo, hydroxy)-substituted benzo- [4,5]thiazolo[3,2-a]pyrimidine [7][8][9] and its benzofused derivative, 9,11-(oxo, hydroxy)-naphtha-[1',2':4,5]thiazolo[3,2-а]pyrimidine [10] no proofs of the structure was published allowing a conclusion on the existence of a definite tautomer among А-C.…”

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confidence: 99%

Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives

et al. 2015

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Heating a mixture of substituted malonic esters and 6-methoxy-1,3-benzothiazolyl-2-amine afforded new derivatives of benzo [4,5]thiazolo[3,2-a]pyrimidine, 3-substituted 2-hydroxy-4Н-benzo[4,5]thiazolo[3,2-a]pyrimidine-4-ones. The choice between the possible tautomers was carried out basing on the Xray diffraction analysis of 3-formyl-2-chloro derivative synthesized by formylation of unsubstituted heterocycle by Vilsmeier reaction.The interest to the synthesis and investigation of derivatives of fused pyrimidines is due to the wide range of the biological activity exhibited by this class of heterocycles, including antitumor, antibacterial, antiviral, antiinflammation, neurotrophic, and other types of action [1,2].

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Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives

et al. 2015

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Organocatalytic asymmetric [4+2] cyclization of 2-benzothiazolimines with azlactones: access to chiral benzothiazolopyrimidine derivatives

Wang

et al. 2020

Chem. Commun.

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Organocatalytic enantioselective aza-Friedel–Crafts reaction between benzothiazolimines and 2-naphthols for the preparation of chiral 2′-aminobenzothiazolomethyl naphthols

Xiang

Zhang

et al. 2021

Org. Biomol. Chem.

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<i>In vitro</i> Activity and Safety Assessment of New Synthesized Thiazolo Pyrimidine Derivatives Augmented with Albendazole against <i>Echinococcus Multilocularis</i> Metacestodes in Balb/C Mice

Cited by 3 publications

References 19 publications

Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives

Synthesis and properties of new benzo[4,5]thiazolo[3,2-a]pyrimidine derivatives

Organocatalytic asymmetric [4+2] cyclization of 2-benzothiazolimines with azlactones: access to chiral benzothiazolopyrimidine derivatives

Organocatalytic enantioselective aza-Friedel–Crafts reaction between benzothiazolimines and 2-naphthols for the preparation of chiral 2′-aminobenzothiazolomethyl naphthols

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