&lt;i&gt;Helicobacter pylori&lt;/i&gt;: the causative agent of peptic ulcer

Shamsuddeen, U; Yusha’u, M; Adamu, IA

doi:10.4314/bajopas.v2i2.63788

Cited by 4 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to HIES (2016), gastric ulcers among urban dwellers (20.3%) are most common; in the present study, gastric ulcers were found linked to both safe (piped water into dwelling and yard) and unsafe (river and pond) sources (Table 3). Nonetheless, the increased prevalence of stomach ulcers in surveyed communities might result from an irregular diet, drinking less water, and stress-related factors (Shamsuddeen et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Health Risks Associated With Sources of Water: An Exploratory Study From Turag-Tongi Riparian Areas, Bangladesh

Prodhan,

Nasreen

2023

J. Asiat. Soc. Bangladesh, Sci.

View full text Add to dashboard Cite

The present study aims to investigate the available water sources for drinking and domestic purposes and their relationship with the occurrence of diseases in a given community. To accomplish this, 1826 households in the Turag River area of Tongi at twelve different locations were surveyed. Six focus group discussions (FGDs) and twelve key informant interviews (KIIs) were also conducted in six different Turag River locations. Data on water quality has been gathered from various government surveys (BNDWQS, 2011; BBS, 2017; SVRS, 2019, etc.), international reports (WHO, World Bank, etc.), individual studies, and other relevant sources. Of all the recorded (13) drinking water sources, motorized tubewells were the most common and were used by 73.8 percent of respondents. Other sources include pipe connections into the yard (16.7%) and dwelling (4.5%), deep and shallow tube wells (2.6%), public tap water (2.1%) etc. The study also revealed that a notable percentage (2.8%) of the survey population still depended on open sources such as rainwater, rivers, lakes, ponds, etc., for drinking and domestic purposes. The respondents also reported the presence of yellow crust (iron) and other unwanted components in their water sources, with foul odors and unpleasant tastes. It has also been documented that the communities have been suffering from various diseases, such as diarrhea, skin diseases, dysentery, malaria, jaundice, typhoid, tuberculosis, pneumonia, cholera, etc. diseases over the past year. The Spearman's rho (ρ’s) test showed significant associations between these diseases and the water sources. The issues identified by the present study are likely to aid policymakers in including water and health concerns in national policy and ensuring access to sustainable water resources, aligning with SDGs 6.1, 6.3, and 6.4. J. Asiat. Soc. Bangladesh, Sci. 49(2): 121-138, December 2023

show abstract

Section: Discussionmentioning

confidence: 99%

Health Risks Associated With Sources of Water: An Exploratory Study From Turag-Tongi Riparian Areas, Bangladesh

Prodhan,

Nasreen

2023

J. Asiat. Soc. Bangladesh, Sci.

View full text Add to dashboard Cite

show abstract

“…It was identified in 1982 (1). It has been established that H. pylori infection is a major cause of chronic gastritis and peptic ulcer disease (2). H. pylori is the causative agent for acute and chronic gastritis and gastric lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Suppression of Helicobacter Pylori in Mice Intestine by Ingestion of Lactic Acid Bacteria in Yoghurt

O¹,

Emenuga²,

Uche³

et al. 2014

IOSRJDMS

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is a major cause of chronic gastritis and peptic ulcer. Antibioticsbased H. pylori eradication treatment is 90% effective, but it is expensive and can have side effects and antibiotic resistance. Probiotics costs less and are easily available. These studies were conducted to investigate the role of probiotics in the treatment of H. pylori infection. H. pylori were recovered from stool culture of peptic ulcer patients. Twenty albino wister mice weighing (25g-29g) were kept in 5cages, A to E (4 mice per cage). Faecal occult blood (FOB) test and viable bacterial count (VBC) were done on all the mice at different stages of the experiment. Animals in cages A to D were fed orally with different concentrations of H. pylori for 1week. Animals in cage E were fed with water as control. Finally the test mice were fed for another one week with yogurt which contains lactic acid bacteria then a retest was done. The results generated showed that the H.pylori can induce stomach ulcer and the Lactic acid bacteria in the yogurt suppressed the ulcer disease. Conclusively, this study has proven that Lactic acid bacteria in yoghurt can suppress Helicobacter pylori infection in mice.

show abstract

Molecular Docking and Quantitative Structure-Activity Relationship (Qsar) Studies of Some Selected Anti-Ulcer Inhibitors

2019

View full text Add to dashboard Cite

Proton pump inhibitors portray the first choice for treating various ulcer disease, because they inhibis H + /K +-ATpase enzyme by covalently binding to a cysteine residue of either potassium or proton pump. Therefore, this enzyme is a validated target for anti-ulcer remedy/drugs. A quantitative structure-activity relationship and molecular docking studies have been made on 30 benzo[d]thiazole series as H + /K +-ATPase inhibitors. Density Functional Theory was used to optimize the geometry of the anti-ulcer compounds. Four types of molecular descriptors were generated in other to know the relationship that exit between anti-ulcer activity and structural properties of these compounds. The QSAR result revealed high statistically significant correlation coefficients R 2 = 0.9401, R 2 adj = 0.9250, Q 2 LOO = 0.8842 and R 2 pred= 0.7975. Our QSAR model showed an excellent predictive activity with the chemical properties of the compounds. The results of the docking analysis revealed that most of the compounds showed a very good relationship with the active receptor, with a better docking score of-9.1kcal/mol. The physicochemical parameters are to be considered when improving the inhibitory activities of benzo[d]thiazole against the enzyme that causes the ulcer

show abstract

<i>Helicobacter pylori</i>: the causative agent of peptic ulcer

Cited by 4 publications

References 16 publications

Health Risks Associated With Sources of Water: An Exploratory Study From Turag-Tongi Riparian Areas, Bangladesh

Health Risks Associated With Sources of Water: An Exploratory Study From Turag-Tongi Riparian Areas, Bangladesh

Suppression of Helicobacter Pylori in Mice Intestine by Ingestion of Lactic Acid Bacteria in Yoghurt

Molecular Docking and Quantitative Structure-Activity Relationship (Qsar) Studies of Some Selected Anti-Ulcer Inhibitors

Contact Info

Product

Resources

About