<i>Helicobacter pylori</i> Infection and the Respiratory System: A Systematic Review of the Literature

Abstract

Background: Recent studies suggest an increased Helicobacter pylori prevalence in patients with various extradigestive inflammatory diseases. Similar to H. pylori infection, many respiratory diseases are characterized by chronic inflammation as well as increased immune response. Recent studies have evaluated the relation between various respiratory disorders and H. pylori infection. The aim of this systematic review was to scrutinize the relevant literature and the mechanisms that could underlie a role for H. pylori infection in respiratory diseases. Methods: Relevant literature regarding pathophysiological mechanisms and clinical epidemiology of H. pylori and different respiratory diseases has been systematically identified and analyzed by two independent reviewers according to a PubMed search for English language (until week 14, April 2010). Conclusions: At present, there is no definite proof of a causal relationship between H. pylori and respiratory diseases. Both H. pylori and various respiratory diseases are characterized by the release of proinflammatory cytokines and attraction of granulocytes as well as B- and T-cell-mediated response, though a pathophysiological association has not been proven. Neither the role of genetic predisposition of the host nor the presence of virulence factors nor the impact of H. pylori eradication have been studied in detail and definitely need further evaluation.

The state of asthma epidemiology: an overview of systematic reviews and their quality

“…A total of four systematic reviews on Helicobacter pylori infection were included, one of poor quality [28]. The other three all conducted their search up to April to July 2012 [29–31].…”

Activation of Helicobacter Pylori Causes Either Autoimmune Thyroid Diseases or Carcinogenesis in the Digestive Tract

“…pylori and the CagA gene have frequently S294 Astl and Šterzl Vol. 64 been detected in asthma patients (Malfertheiner et al 2011, Wang et al 2013, extragastric disease (Banic et al 2012, Figura et al 2010, Lukes et al 2013, Pellicano et al 2009) and in nasal polyp specimens and the inflamed mucosa of the paranasal sinus in patients with chronic rhinosinusitis (Dinis et al 2005, Kaviani et al 2009, Morinaka et al 2003, Ozyurt et al 2009). H. pylori might play a positive role in chronic rhinosinusitis.…”

The Study of Association between Helicobacter pylori (H. pylori) and Chronic Obstructive Pulmonary Disease (COPD)

“…Both H. pylori and various respiratory diseases are characterized by the release of proinflammatory cytokines and attraction of granulocytes as well as Band T-cell-mediated response, though a pathophysiological association has not been proven. Neither the role of genetic predisposition of the host nor the presence of virulence factors nor the impact of H. pylori eradication have been studied in detail and definitely need further evaluation [88][89][90]. In 2011 Ahmed, Azza M, Motawie, Ayat A, ElSahrigy, Sally A. F, Kantoush, Nagwa A, Abdel-Ghany, Somaya M., Abdel-Shakour and Usama studied about Helicobacter Pylori infection in Egyptian children with Bronchial Asthma.…”