&lt;i&gt;Haemophilus parainfluenzae&lt;/i&gt; Lung Abscess

Rh, Israel; Cr, Magnussen; Dw, Greenblatt; Hp, Patanella

doi:10.1159/000194715

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…In contrast, 1t. parainfluenzae is only rarely identified as the cause of invasive infections [5,6] H. influenzae, unlike H. parainfluenzae, has an essential requirement for haem which may serve as a source of both iron and essential porphyrins [7][8][9]. However, haemin in amounts sufficient to satisfy prophyrin requirements only partially supplies the iron necesary for growth in vitro [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae

Williams

1986

FEMS Microbiology Letters

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Section: Introductionmentioning

confidence: 99%

Influence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae

Williams

1986

FEMS Microbiology Letters

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“…Infrequent instances of pulmonary infection caused by this bacterium arise when Haemophilus parainfluenzae is inhaled from the oropharynx into the lungs, occasionally resulting in empyema [ 42 ]. Previously reported patients who suffered from pulmonary abscesses caused by Haemophilus parainfluenzae exhibited immunosuppression, such as diabetes [ 43 ] or malignancy [ 44 ]. In conclusion, the detection outcomes obtained through mNGS are progressively enhancing our comprehension of the pathogenic nature of commonly colonizing bacteria.…”

Section: Discussionmentioning

confidence: 99%

A single-center, retrospective study of hospitalized patients with lower respiratory tract infections: clinical assessment of metagenomic next-generation sequencing and identification of risk factors in patients

Gao,

Li,

et al. 2024

Respir Res

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Introduction Lower respiratory tract infections(LRTIs) in adults are complicated by diverse pathogens that challenge traditional detection methods, which are often slow and insensitive. Metagenomic next-generation sequencing (mNGS) offers a comprehensive, high-throughput, and unbiased approach to pathogen identification. This retrospective study evaluates the diagnostic efficacy of mNGS compared to conventional microbiological testing (CMT) in LRTIs, aiming to enhance detection accuracy and enable early clinical prediction. Methods In our retrospective single-center analysis, 451 patients with suspected LRTIs underwent mNGS testing from July 2020 to July 2023. We assessed the pathogen spectrum and compared the diagnostic efficacy of mNGS to CMT, with clinical comprehensive diagnosis serving as the reference standard. The study analyzed mNGS performance in lung tissue biopsies and bronchoalveolar lavage fluid (BALF) from cases suspected of lung infection. Patients were stratified into two groups based on clinical outcomes (improvement or mortality), and we compared clinical data and conventional laboratory indices between groups. A predictive model and nomogram for the prognosis of LRTIs were constructed using univariate followed by multivariate logistic regression, with model predictive accuracy evaluated by the area under the ROC curve (AUC). Results (1) Comparative Analysis of mNGS versus CMT: In a comprehensive analysis of 510 specimens, where 59 cases were concurrently collected from lung tissue biopsies and BALF, the study highlights the diagnostic superiority of mNGS over CMT. Specifically, mNGS demonstrated significantly higher sensitivity and specificity in BALF samples (82.86% vs. 44.42% and 52.00% vs. 21.05%, respectively, p < 0.001) alongside greater positive and negative predictive values (96.71% vs. 79.55% and 15.12% vs. 5.19%, respectively, p < 0.01). Additionally, when comparing simultaneous testing of lung tissue biopsies and BALF, mNGS showed enhanced sensitivity in BALF (84.21% vs. 57.41%), whereas lung tissues offered higher specificity (80.00% vs. 50.00%). (2) Analysis of Infectious Species in Patients from This Study: The study also notes a concerning incidence of lung abscesses and identifies Epstein-Barr virus (EBV), Fusobacterium nucleatum, Mycoplasma pneumoniae, Chlamydia psittaci, and Haemophilus influenzae as the most common pathogens, with Klebsiella pneumoniae emerging as the predominant bacterial culprit. Among herpes viruses, EBV and herpes virus 7 (HHV-7) were most frequently detected, with HHV-7 more prevalent in immunocompromised individuals. (3) Risk Factors for Adverse Prognosis and a Mortality Risk Prediction Model in Patients with LRTIs: We identified key risk factors for poor prognosis in lower respiratory tract infection patients, with significant findings including delayed time to mNGS testing, low lymphocyte percentage, presence of chronic lung disease, multiple comorbidities, false-negative CMT results, and positive herpesvirus affecting patient outcomes. We also developed a nomogram model with good consistency and high accuracy (AUC of 0.825) for predicting mortality risk in these patients, offering a valuable clinical tool for assessing prognosis. Conclusion The study underscores mNGS as a superior tool for lower respiratory tract infection diagnosis, exhibiting higher sensitivity and specificity than traditional methods.

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A Series ofHaemophilus parainfluenzaeSurgical Infections and Review of the Literature

Onafowokan

Mateo

Bonatti

2021

Surgical Infections

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<i>Haemophilus parainfluenzae</i> Lung Abscess

Abstract: To our knowledge, Haemophilus parainfluenzae lung abscess has not been described previously. Such a case is presented in the setting of diabetes mellitus. The implications of diagnosis and management are discussed

Cited by 5 publications

References 7 publications

Influence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae

Influence of iron restriction on growth and the expression of outer membrane proteins by Haemophilus influenzae and H. parainfluenzae

A single-center, retrospective study of hospitalized patients with lower respiratory tract infections: clinical assessment of metagenomic next-generation sequencing and identification of risk factors in patients

A Series ofHaemophilus parainfluenzaeSurgical Infections and Review of the Literature

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