&lt;i&gt;FTO&lt;/i&gt; Genotype and BMI Reduction in Childhood Obesity Interventions: A Systematic Review and Meta-Analysis

Chen, Jing; Xiao, Wu-Cai; Zhao, Jiajun; Heitkamp, Melanie; Liu, Zheng

doi:10.2139/ssrn.4159554

Cited by 1 publication

(1 citation statement)

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“…A recent systematic review and meta‐analysis of trials on the association of the FTO genotype with the response to lifestyle interventions analysed 13 studies with 3980 children with overweight and obesity and found that the FTO risk allele had no association with changes in BMI Z‐score, BMI, waist circumference, waist‐to‐hip ratio or body fat percentage after lifestyle interventions. This result suggests that children with the FTO risk allele respond equally to obesity interventions compared with children without the FTO risk allele [36]. Furthermore, Luis et al.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different FTO Genotypes

Roumi,

Salimi,

Mahmoudi

et al. 2024

Endocrino Diabet & Metabol

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BackgroundThe FTO gene polymorphisms may influence the effects of lifestyle interventions on obesity. The present study aimed to assess the influence of the rs9930506 FTO gene polymorphism on the success of a comprehensive weight loss intervention in male adolescents with overweight and obesity.MethodsThis study was carried out on 96 adolescent boys with overweight and obesity who were randomly assigned to the intervention (n = 53) and control (n = 43) groups. The blood samples of the participants were collected, and the FTO gene was genotyped for the rs9930506 polymorphism. A comprehensive lifestyle intervention including changes in diet and physical activity was performed for 8 weeks in the intervention group.ResultsFollowing the lifestyle intervention, BMI and fat mass decreased significantly in the intervention group compared with the control group (both p < 0.05), while no change was found in weight, height or body muscle percentage between the groups. The participants in the intervention group with the AA/AG genotype and not in carriers of the GG genotype had a significantly higher reduction in BMI (−1.21 vs. 1.87 kg/m2, F = 4.07, p < 0.05) compared with the control group.ConclusionThe intervention in individuals with the AA/AG genotype has been significantly effective in weight loss compared with the control group. The intervention had no association effect on anthropometric indices in adolescents with the GG genotype of the FTO rs9930506 polymorphism.Trial RegistrationName of the registry: National Nutrition and Food Technology Research Institute; Trial registration number: IRCT2016020925699N2; Date of registration: 24/04/2016; URL of trial registry record: https://www.irct.ir/trial/21447

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Section: Discussionmentioning

confidence: 99%