&lt;i&gt;FADS2&lt;/i&gt; and &lt;i&gt;ELOVL6&lt;/i&gt; mutation frequencies in Japanese Crohn's disease patients

Motoi, Yutaro; Ito, Zensho; Suzuki, Shizuka; Takami, Shiro; Matsuo, Kaori; Sato, Mio; Ota, Yuki; Tsuruta, Mizuki; Kojima, Masahiro; Noguchi, Mitsutaka; Uchiyama, Kan; Kubota, Takeshi

doi:10.5582/ddt.2019.01081

Cited by 4 publications

(4 citation statements)

References 16 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these genes, Cxcl2 as a gene with known involvement in the immune response exhibited the greatest up-regulation ( 35 ). Fads2 , a gene reported to be mutation-prone in IBD patients, showed the greatest downregulation in our study ( 40 ).…”

Section: Resultsmentioning

confidence: 53%

See 1 more Smart Citation

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

View full text Add to dashboard Cite

Liver injury is a common complication of inflammatory bowel disease (IBD). However, the mechanisms of liver injury development are not clear in IBD patients. Gut microbiota is thought to be engaged in IBD pathogenesis. Here, by an integrated analysis of host transcriptome and colonic microbiome, we have attempted to reveal the mechanism of liver injury in colitis mice. In this study, dextran sulfate sodium (DSS) -induced mice colitis model was constructed. Liver transcriptome showed significant up- and down-regulation of pathways linked to immune response and lipid metabolism, respectively. Whilst the colon transcriptome exhibited dramatic alterations in immune response and pathways associated with cell growth and death. The microbiota of DSS-treated mice underwent strong transitions. Correlation analyses identified genes associated with liver and colon injury, whose expression was associated with the abundance of liver and gut health-related bacteria. Collectively, the results indicate that the liver injury in colitis mice may be related to the intestinal dysbiosis and host-microbiota interactions. These findings may provide new insights for identifying potential targets for the treatment of IBD and its induced liver injury.

show abstract

Section: Resultsmentioning

confidence: 53%

“…Fads2, a gene reported to be mutation-prone in IBD patients, showed the greatest downregulation in our study (40).…”

Section: Dss Treatment Induced Colon Histopathology and Gene Expression Alterations In Micementioning

confidence: 47%

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Only some gene sequencing revealed differences in the ELOVL gene between IBD patients and healthy individuals. Genetic sequencing of two CD patients in Japan revealed variations in ELOVL6 ( 178 ), and gene analysis of immune cells from UC patients demonstrated significant upregulation of ELOVL5 ( 179 ). Furthermore, ELOVL7 gene regions were identified as possible novel loci associated with adalimumab response in CD patients ( 180 ).…”

Section: Very Long-chain Fatty Acidsmentioning

confidence: 99%

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

Yan,

Ye,

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Though the pathogenesis of IBD remains unclear, diet is increasingly recognized as a pivotal factor influencing its onset and progression. Fatty acids, essential components of dietary lipids, play diverse roles in IBD, ranging from anti-inflammatory and immune-regulatory functions to gut-microbiota modulation and barrier maintenance. Short-chain fatty acids (SCFAs), products of indigestible dietary fiber fermentation by gut microbiota, have strong anti-inflammatory properties and are seen as key protective factors against IBD. Among long-chain fatty acids, saturated fatty acids, trans fatty acids, and ω-6 polyunsaturated fatty acids exhibit pro-inflammatory effects, while oleic acid and ω-3 polyunsaturated fatty acids display anti-inflammatory actions. Lipid mediators derived from polyunsaturated fatty acids serve as bioactive molecules, influencing immune cell functions and offering both pro-inflammatory and anti-inflammatory benefits. Recent research has also highlighted the potential of medium- and very long-chain fatty acids in modulating inflammation, mucosal barriers, and gut microbiota in IBD. Given these insights, dietary intervention and supplementation with short-chain fatty acids are emerging as potential therapeutic strategies for IBD. This review elucidates the impact of various fatty acids and lipid mediators on IBD and delves into potential therapeutic avenues stemming from these compounds.

show abstract

“…Dysregulated lipid metabolism and altered production of pro-inflammatory lipid mediators have been implicated in IBD pathogenesis. ELOVLs are involved in the synthesis of inflammatory lipid mediators, such as leukotrienes and prostaglandins, which contribute to the inflammatory process in IBD [40].…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology

Wang,

Yu,

Gao

et al. 2023

Eur J Med Res

View full text Add to dashboard Cite

Background The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in lipid metabolism and cellular functions. This comprehensive review explores the structural characteristics, functional properties, and physiological significance of individual ELOVL isoforms, providing insights into lipid biosynthesis, cell membrane dynamics, and signaling pathways. Aim of review This review aims to highlight the significance of the ELOVL family in normal physiology and disease development. By synthesizing current knowledge, we underscore the relevance of ELOVLs as potential therapeutic targets. Key scientific concepts of review We emphasize the association between dysregulated ELOVL expression and diseases, including metabolic disorders, skin diseases, neurodegenerative conditions, and cancer. The intricate involvement of ELOVLs in cancer biology, from tumor initiation to metastasis, highlights their potential as targets for anticancer therapies. Additionally, we discuss the prospects of using isoform-specific inhibitors and activators for metabolic disorders and cancer treatment. The identification of ELOVL-based biomarkers may advance diagnostics and personalized medicine. Conclusion The ELOVL family's multifaceted roles in lipid metabolism and cellular physiology underscore its importance in health and disease. Understanding their functions offers potential therapeutic avenues and personalized treatments.

show abstract

<i>FADS2</i> and <i>ELOVL6</i> mutation frequencies in Japanese Crohn's disease patients

Cited by 4 publications

References 16 publications

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology

Contact Info

Product

Resources

About