&lt;i&gt;Demodex &lt;/i&gt;Mites – Commensals, Parasites or Mutualistic Organisms?

Lacey, Noreen; Raghallaigh, Síona Ní; Powell, Frank C.

doi:10.1159/000323009

Cited by 124 publications

(127 citation statements)

References 18 publications

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“…Demodex species, like other cutaneous microbes, play different roles depending on host status (Cogen et al 2008). Several factors, such as age, gender, skin type, and presence of lesions and erythema, could allow infestation of Demodex species (Lacey et al 2011). Conversely, in our results, infestation of Demodex species in patients with cancer did not differ significantly according to dermatological and demographic parameters.…”

Section: Discussioncontrasting

confidence: 68%

Associations between Demodex species infestation and various types of cancer

Sönmez

Yalçın

Karakeçe

et al. 2013

Acta Parasitologica

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Tumor-associated immune system cells secrete protease and cytokines that can inhibit the immune response. In particular, T-cell effector functions could be inhibited, potentially causing an increase in parasitic infestations. Demodex species are common inhabitants of normal hair follicles. Humans are the specific host for two species Demodex folliculorum and D. brevis. The aim of this study was to investigate the incidence and infestation of D. folliculorum and D. brevis in patients with cancer. In the present study, 101 patients with cancer were selected from among patients who were diagnosed and treated for cancer. The cancer patients were divided into four groups according to cancer type. Slides were examined for parasites using light microscopy at magnifications of ×40 and ×100. Infestation was defined as having at least five living parasites/cm 2 of skin. The ages of the patients with cancer ranged between 38 and 82 years, with a mean of 65.5±10.1 years. It was determined that 77 of the 101 (76.2%) cancer patients were positive for Demodex species. Infestation was positive in 18 (47.4%) of the 38 cases in the breast cancer group, 7 (29.2%) of the 24 cases in the lung cancer group, 5 (18.5%) of the 27 cases in the gastrointestinal system cancer group, and 2 (16.7%) of the 12 cases in the urogenital system cancer group. Results showed that the rate of Demodex species infestation was higher in patients with breast cancer. Thus, cancer -and particularly breast cancer -is a risk factor for Demodex species infestation.

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Section: Discussioncontrasting

confidence: 68%

Associations between Demodex species infestation and various types of cancer

Sönmez

Yalçın

Karakeçe

et al. 2013

Acta Parasitologica

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“…Gaitanın mikroskobik incelenmesi ile elde edilen sonuçların kullanılan yönteme, örneğin kıvamına, kan ve mukus içerip içermedi-ğine, laboratuvar çalışanlarının niteliklerine göre farklılıklar gös-terdiği bildirilmektedir (2,4,6). Gerçekten bağırsak parazitlerinin doğru tanı ve tedavisinde, gaita örneklerinin doğru şekilde toplanması, uygun şekilde ve sürede taşınması, saklanması, örnekle-rin yeterli miktarda olması gibi laboratuvar öncesi uygulamaların yanı sıra, laboratuvara ulaşan örneklerin doğru yöntemlerle işle-me alınması, deneyimli uzmanlar tarafından değerlendirilmesi ve doğru şekilde raporlanması da son derece önemlidir (8,9).…”

Section: Discussionunclassified

“…Ancak böyle sistemleri oluş-turmak son derece zor ve pahalı olabilir. Ayrıca test prosedürleri ve uygulayıcılar arasındaki farklılıklar nedeniyle bu tür sistemlerin değerlendirilmesinde de zorluklar yaşanmaktadır (4,5). Modern tanı laboratuvarlarının tek sorunu bağırsak parazitlerinin rutin tanı-sında kullanılan yöntemin mikroskobik incelenmesi değil, aynı zamanda bu testin doğruluğunun da yeterince değerlendirileme-mesidir (6).…”

Section: Introductionunclassified

Comparison of Individual Differences in the Direct Microscopic Examination in the Diagnosis of Intestinal Parasites

Doğan¹,

Oz²,

Kocman³

et al. 2013

TurkiyeParazitolDerg

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ÖZETAmaç: Bağırsak parazitlerinin tanısında direkt mikroskobik incelemenin ve farklı mikroskobistlerden elde edilen sonuçlar arasındaki farklılığın öneminin vurgulanması amaçlanmıştır. Yöntemler: Diyareli 225 çocuktan gaita örnekleri toplandı, makroskobik inceleme sonrası formalin-eter çöktürme yöntemiyle hazırlandı ve birbirinden bağımsız 3 farklı araştırmacı (parazitoloji uzmanı, mikrobiyoloji uzmanı ve ikinci yılını tamamlamış bir mikrobiyoloji araştırma görevlisi) tarafından mikroskobik incelemeye alındı.

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“…Various kinds of Demodex mites may infest the skin of the host, depending on the preferred area on the skin (Lacey et al, 2009). In many cases, mite infestation is asymptomatic and their role remains unclear (Lacey et al, 2011). The pathogenic role of Demodex mites is well-documented in dogs where Demodex canis causes demodicosis -a serious, potentially fatal disease connected with numerous skin and ocular symptoms (Gortel, 2006).…”

Section: Demodex Mitesmentioning

confidence: 99%

“…They emerge from the pilosebaceous units at night and migrate across the surface of the skin to find a mating partner, travelling at a speed of about 16 mm h 21 (Lacey et al, 2011). The life cycle of Demodex mites consists of five phases of development and lasts from 14 to 18 days.…”

Section: Demodex Life Cyclementioning

confidence: 99%

Potential role of Demodex mites and bacteria in the induction of rosacea

Jarmuda

O'Reilly

Żaba

et al. 2012

Journal of Medical Microbiology

160

111

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Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3 % of the world's population and a number of subtypes are recognized. Rosacea can be treated with a variety of antibiotics (e.g. tetracycline or metronidazole) yet no role for bacteria or microbes in its aetiology has been conclusively established. The density of Demodex mites in the skin of rosacea patients is higher than in controls, suggesting a possible role for these mites in the induction of this condition. In addition, Bacillus oleronius, known to be sensitive to the antibiotics used to treat rosacea, has been isolated from a Demodex mite from a patient with papulopustular rosacea and a potential role for this bacterium in the induction of rosacea has been proposed. Staphylococcus epidermidis has been isolated predominantly from the pustules of rosacea patients but not from unaffected skin and may be transported around the face by Demodex mites. These findings raise the possibility that rosacea is fundamentally a bacterial disease resulting from the over-proliferation of Demodex mites living in skin damaged as a result of adverse weathering, age or the production of sebum with an altered fatty acid content. This review surveys the literature relating to the role of Demodex mites and their associated bacteria in the induction and persistence of rosacea and highlights possible therapeutic options.

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<i>Demodex </i>Mites – Commensals, Parasites or Mutualistic Organisms?

Cited by 124 publications

References 18 publications

Associations between Demodex species infestation and various types of cancer

Associations between Demodex species infestation and various types of cancer

Comparison of Individual Differences in the Direct Microscopic Examination in the Diagnosis of Intestinal Parasites

Potential role of Demodex mites and bacteria in the induction of rosacea

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