&lt;em&gt;In Vitro&lt;/em&gt; Biocompatibility Study and Electrical Properties of the PEDOT, PEDOT Collagen-Coat, PEDOT Nanotubes and PEDOT Aerogels for Neural Electrodes

Starbird, Ricardo; Krautschneider, Wolfgang H.; Blume, Grit; Bauhofer, W.

doi:10.2316/p.2013.791-072

Cited by 4 publications

(4 citation statements)

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“…PEDOT was chosen as a coating because of its excellent electrical properties like low impedance of the electrode-electrolyte-interface, a high charge injection capacity (CIC), and a high charge storage capacity [ 8 ]. PEDOT-coated electrodes do not exhibit the typical capacitive behavior of metal electrodes due to interface polarization (formation of a Helmholtz-layer) at lower frequencies [ 10 ]. The easy processing, the good thermal and chemical stability [ 8 ] and its excellent biocompatibility [ 11 ] were additional criteria for choosing PEDOT as a coating material.…”

Section: Methodsmentioning

confidence: 99%

Electrical Stimulation of NIH-3T3 Cells with Platinum-PEDOT-Electrodes Integrated in a Bioreactor

Blume¹,

Müller-Wichards²,

Goepfert³

et al. 2013

TOBEJ

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The objective of this work involves the development and integration of electrodes for the electrical stimulation of cells within a bioreactor. Electrodes need to fit properties such as biocompatibility, large reversible charge transfer and high flexibility in view of their future application as implants on the tympanic membrane. Flexible thin-film platinum-poly(3,4-ethylene-dioxythiophene)-electrodes on a poly(ethylene terephthalate)-foil manufactured using microsystems technology were integrated into a bioreactor based on the design of a 24 well plate. The murine fibroblast cell line NIH-3T3 was cultured on the foil electrodes and the cells were stimulated with direct voltage and unipolar pulsed voltage. The amplitude, the pulse length and the ratio of pulse to pause were varied. The stimulated cells were stained in order to determine the angle between the cell cleavage plane of the dividing cells and the vector of the electric field. These angles were subsequently used to calculate the polarization index, which is a measure of the orientation of the metaphase plane of dividing cells that occurs for example during wound healing or embryonic morphogenesis.

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Section: Methodsmentioning

confidence: 99%

Electrical Stimulation of NIH-3T3 Cells with Platinum-PEDOT-Electrodes Integrated in a Bioreactor

Blume¹,

Müller-Wichards²,

Goepfert³

et al. 2013

TOBEJ

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“…The probes can be cleaned, but it still has to be tested whether this is sufficient for FDA approval. Furthermore, studies have shown that PEDOT can be made biocompatibility [8][9], although the long-term stability for this application still has to be investigated. The next issue is charge injection capacity.…”

Section: Polymer Electrodesmentioning

confidence: 99%

Advances in cochlear implants

French

Lawand²,

Miralles

2022

2022 International Semiconductor Conference (CAS)

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Cochlear implants restore hearing to many people around the world. These devices are hand-made and have limitations in terms of sound quality. The maximum number of electrodes at present is 22 and this means that the sound spectrum is divided into 22 blocks. Furthermore, the breadth of the implant limits penetration and thus lower frequencies are lost. Silicon based technology enables an increase in the number of electrodes and also a reduction in the cross-section of the probe. This will improve sound quality and reduce risks of damage during insertion. This paper shows the development of new technologies to improve the quality of cochlear implants. These involve a move to polymers which make use of silicon-based technology in their manufacture.

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“…Lab-on-a-chip microsensors usually require consideration of temperature, pressure and compatibility with chemical and biological samples to avoid interferences in the measurement or sensor degradation. Common electrode materials for biosensors are platinum, gold, silver, stainless steel and PEDOT-covered gold [53,54] due to their low conductivity, good mechanical characteristics, chemical inertness and large operating voltage range. Lab-ona-chip can benefit from PEDOT-covered gold, which offers the advantage of lower impedance in the low frequency range.…”

Section: Microsensorsmentioning

confidence: 99%

Lab-on-a-Chip Devices and Opportunities for Latin America and the Caribbean

Castillo¹,

Philips²,

Jara³

et al. 2015

Proceedings of the 13th Latin American and Caribbean Conference for Engineering and Technology Engineering Education Facing The

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Lab on a chip devices are an alternative for accessible, cost-effective and early detection medical tests. MEMS technologies provide possibilities for reduction of reagent volume, sample size and fast in-situ diagnosis. This review summarizes the main working principles and applications of Lab on a Chip devices and their potential for strengthening research at higher education facilities and improving the health systems in Latin America and the Caribbean.

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<em>In Vitro</em> Biocompatibility Study and Electrical Properties of the PEDOT, PEDOT Collagen-Coat, PEDOT Nanotubes and PEDOT Aerogels for Neural Electrodes

Cited by 4 publications

References 0 publications

Electrical Stimulation of NIH-3T3 Cells with Platinum-PEDOT-Electrodes Integrated in a Bioreactor

Electrical Stimulation of NIH-3T3 Cells with Platinum-PEDOT-Electrodes Integrated in a Bioreactor

Advances in cochlear implants

Lab-on-a-Chip Devices and Opportunities for Latin America and the Caribbean

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