2022
DOI: 10.34117/bjdv8n12-263
|View full text |Cite
|
Sign up to set email alerts
|

<em>In silico</em> pharmacokinetic and toxicological study of Flavone analogues

Abstract: Flavone analogs are natural compounds of the flavonoid class that have a wide range of biological activities. The present study aimed to predict, with the aid of in silico methodologies, the oral bioavailability and pharmacokinetic and toxicological analyzes for three flavone analogues (apigenin, chrysin and luteonlin). The study revealed that the analogues have good oral availability, favorable pharmacokinetic and toxicological parameters. The Virtual Screening performed to predict oral bioavailability reveal… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
3
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
2
1
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(3 citation statements)
references
References 12 publications
(14 reference statements)
0
3
0
Order By: Relevance
“…The permeability of chemical compounds through the blood-brain barrier (BBB) consists of passing through endothelial cells that have tight and compacted junctions, which considerably restricts the permeability of the compounds, ensuring that the drug candidate does not cross the BBB, otherwise, it would increase considerably the probability of having side effects (adverse effects) (THOMAS, 2003). In the capillary endothelia of cerebral vessels, the presence of P-glycoprotein is essential, as it acts as a defense mechanism capable of pumping back into the blood the xenobiotic chemical substances that could eventually cross the blood-brain barrier (ARAUJO et al, 2022), (CEZÁRIO et al, 2022), .…”
Section: A Look At Developmentmentioning
confidence: 99%
See 2 more Smart Citations
“…The permeability of chemical compounds through the blood-brain barrier (BBB) consists of passing through endothelial cells that have tight and compacted junctions, which considerably restricts the permeability of the compounds, ensuring that the drug candidate does not cross the BBB, otherwise, it would increase considerably the probability of having side effects (adverse effects) (THOMAS, 2003). In the capillary endothelia of cerebral vessels, the presence of P-glycoprotein is essential, as it acts as a defense mechanism capable of pumping back into the blood the xenobiotic chemical substances that could eventually cross the blood-brain barrier (ARAUJO et al, 2022), (CEZÁRIO et al, 2022), .…”
Section: A Look At Developmentmentioning
confidence: 99%
“…The liver is the main drug-metabolizing organ, and the three major components in the metabolizing process are the reagents (drug or xenobiotic), the product (metabolite), and the catalyst of the biochemical reaction (liver enzymes). Hepatocytes have an apparatus of enzymes responsible for hepatic metabolism, located in the membranes of the smooth endoplasmic reticulum (REL) and rough endoplasmic reticulum (RER) (CEZÁRIO et al, 2022.…”
Section: A Look At Developmentmentioning
confidence: 99%
See 1 more Smart Citation