<em>Hibiscus</em> Anthocyanins Can Selectively Modulate Estrogen Receptor Activity with Favorable Toxicology: a Computational Analysis

Abstract

The estrogen hormone receptor (ER) mediated gene expression mainly regulate the development and physiology of primary and secondary reproductive system alongside bone-forming, metabolism and behaviour. Over-expressed ER is associated with several pathological conditions and play a key role in breast cancer occurrence, progression and metastasis. Hibiscus sabdariffa L. or roselle is a rich source of naturally occurring polyphenolic compounds including anthocyanins and reportedly have strong estrogenic activity. To validate these findings, we have investigated the estrogen receptor binding affinity and safety of some previously recorded polyphenols using a suite of computational methods. Our investigation showed the estrogen-receptor binding potential of Pelargonidin, Delphinidin, Cyanidin, and Hibiscetin are more efficient than popular breast cancer drugs, Tamoxifen and Raloxifene, with favourable toxicological parameters and low half maximal inhibitory concentration. This is the first report to investigate the phytochemical basis of estrogenic activity of Hibiscus sabdariffa L.

Ekstrak Etanol Ubi Jalar Ungu untuk Mencegah Peningkatan pH Vagina setelah Ovariektomi Bilateral pada Tikus Wistar

“…12 Antosianin adalah salah satu sub-grup utama flavanoid, yang biasanya ditemukan pada tanaman yang memiliki warna merah, biru, dan ungu. 13 Sebagaimana flavonoid lainnya seperti ekstrak blackcurrant 14 dan anggur 15 , antosianin juga menunjukkan aktivitas sebagai fitoestrogen. Antosianin memiliki struktur mirip dengan estrogen endogen, sehingga bisa menempel pada kedua jenis reseptor estrogen dan bisa memicu proliferasi sel.…”