&lt;![CDATA[&lt;B&gt;Noncompliance with tuberculosis treatment by patients at a tuberculosis and AIDS reference hospital in midwestern Brazil&lt;/B&gt;]]&gt;

Rabahi, Marcelo Fouad; Rodrigues, Adriana Batista; Mello, Fernanda Queiroz; Netto, Joaquim Caetano de Almeida; Kritski, Afrânio Lineu

doi:10.1590/s1413-86702002000200002

Cited by 28 publications

(38 citation statements)

References 13 publications

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“…( 15 , 16 ) Controlled studies conducted outside Brazil and designed to compare the FDC tablet form of the 2RHZE/4RH regimen with the single-drug tablet form of the same regimen in patients in the intensive phase of treatment have found cure rates ranging from 80.4% to 95.0% and similar cure rates between the two groups of patients. ( 17 - 19 ) …”

Section: Discussionmentioning

confidence: 99%

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

et al. 2013

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OBJECTIVE: To describe the rates of cure, treatment failure, and treatment abandonment obtained with the basic regimen recommended by the Brazilian National Ministry of Health-rifampin, isoniazid, pyrazinamide, and ethambutol for two months, followed by isoniazid and rifampin for four months-involving the use of fixed-dose combination tablets (self-administered treatment), as well as to describe adverse events and their potential impact on treatment outcomes. METHODS: This was a descriptive study based on prospective data obtained from the medical records of tuberculosis patients (≥ 18 years of age) treated with the basic regimen at either of two primary health care facilities in the greater metropolitan area of Goiânia, Brazil. RESULTS: The study sample comprised 40 tuberculosis patients. The rate of cure was 67.5%, the rate of treatment abandonment was 17.5%, and there were no cases of treatment failure. Of the 40 patients in the sample, 19 (47%) reported adverse reactions, which were mild and moderate, respectively, in 87% and 13% of the cases. It was not necessary to alter the regimen or discontinue the treatment in any of the cases evaluated. CONCLUSIONS: The rate of cure obtained with the self-administered, fixed-dose combination tablet form of the new basic regimen was similar to the historical rates of cure obtained with the previous basic regimen. The rate of treatment abandonment in our sample was much higher than that considered appropriate (up to 5%).

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Section: Discussionmentioning

confidence: 99%

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

et al. 2013

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“…Two plausible explanations may justify the differences in the estimates of TB-HIV co-infection in the southeast of Brazil compared to the data reported in this present study: 1) geographical and cultural differences (for example, the use of intravenous drugs) that may interfere in the prevalence of HIV infection in the populations of the regions in question (southeast and northeast of the country); 2) a possible selection bias, since the above-mentioned studies were carried out in reference hospitals for AIDS. Two studies carried out in patients hospitalized in TB reference hospitals, one in the state of Minas Gerais [19] and the other in the state of Goiás [20] reported estimated prevalence rates of co-infection of 10.1% and 9.2%, respectively. These findings are similar to those observed in the present study and were also based on populations of patients hospitalized with TB in tertiary care reference hospitals for this disease.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HIV infection in patients hospitalized for tuberculosis in Bahia, Brazil

Matos¹,

Lemos²,

Bittencourt³

et al. 2007

Braz J Infect Dis

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HIV infection is an important risk factor for the development of tuberculosis (TB), and also affects its morbidity and mortality. This study estimated the prevalence of HIV infection in patients hospitalized for TB in Bahia (in northeastern Brazil) and to evaluate its impact on in-hospital mortality. A total of 375 patients with TB, admitted consecutively to a TB reference hospital in Salvador (Bahia, Brazil), were evaluated between July 2001 and July 2003. Anti-HIV serology was performed in all patients irrespective of clinical and/or epidemiological data suggestive of HIV infection. Death during hospitalization was the principal event-dependent variable. Mean age of patients was 41.4 ± 16.2 years and the male/female ratio was 3.4:1.0. The prevalence of HIV infection was 8.8% (95%CI: 6.2-12.0%). Patients in the HIV-positive group were younger than those in the HIV-negative group (37.1 versus 41.9 years; p=0.05). In-hospital mortality was 10.9% for the whole group (95%CI: 9.4-15.9%), but was significantly greater in the HIV-positive group compared to the HIV-negative group (27.3% versus 9.4%; RR=2.9; 95%CI: 1.5-5.6; p=0.002). The prevalence of HIV infection in patients hospitalized for TB in Bahia (northeastern Brazil) is relatively high (8.8%) and mortality is significantly higher (2.9-fold) in the HIV-positive group. These findings justify carrying out HIV testing, as recommended by the Brazilian Ministry of Health, in all TB patients, particularly those requiring hospitalization.

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“…A reason of this is the percentage of patients who unfortunately interrupt the treatment course [14] and poor compliance with treatment is a real problem for NTPs [15,16]. In order for the treatment to be effective, patients must take their treatment exactly as prescribed for the full amount of time according their baseline characteristics.…”

Section: The Problemmentioning

confidence: 99%

“…Whenever the mycobacterium test was positive, patients were automatically assigned a specific treatment in the CDT their living place refers to. TB treatment was provided totally free of charge as recommended by the WHO [14].…”

Section: Diagnosis and Treatment Of Tuberculosismentioning

confidence: 99%

Default Time from Tuberculosis Treatment in the Southern Republic of Benin Using Mixture Cure Model for Survival Analysis

Tchibozo¹

2015

BBIJ

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<![CDATA[<B>Noncompliance with tuberculosis treatment by patients at a tuberculosis and AIDS reference hospital in midwestern Brazil</B>]]>

Abstract: Our results indicate the importance of establishing Tuberculosis Control Programs in hospitals, while paying special attention to patients with risk factors for noncompliance with TB treatment.

Cited by 28 publications

References 13 publications

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

Desfechos clínicos do tratamento de tuberculose utilizando o esquema básico recomendado pelo Ministério da Saúde do Brasil com comprimidos em dose fixa combinada na região metropolitana de Goiânia

Prevalence of HIV infection in patients hospitalized for tuberculosis in Bahia, Brazil

Default Time from Tuberculosis Treatment in the Southern Republic of Benin Using Mixture Cure Model for Survival Analysis

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