&lt;b&gt;TROPHIC EFFECT OF GLUCAGON-(&lt;i&gt;1-21&lt;/i&gt;)-PEPTIDE ON THE RAT SMALL INTESTINE AND &lt;/b&gt;&lt;b&gt;COLON &lt;/b&gt;

To define the role of glicentin the active site of enteroglucagon, we evaluated the trophic effects of recombinant rat glicentin on rat small intestine and IEC-6 cells. In vivo, a significant increase was observed in jejunal wet weight, protein content, DNA content, and alkaline phosphatase activity after the subcutaneous administration of 100 micrograms/kg per day of glicentin for 2 weeks. In the ileum, however, there were no significant differences between the control versus glicentin groups in any of these parameters. Ornithine decarboxylase (ODC) activity 3.5 h after an intraperitoneal injection of glicentin was increased in the jejunal mucosa, but not in the ileal mucosa. In vitro, glicentin, at a dose of more than 100 ng/ml, significantly increased both tritium-thymidine incorporation and the number of IEC-6 cells. These findings indicate that glicentin exerts direct trophic effects on the rat small-intestinal mucosa and on the rat small-intestinal cell line, IEC-6, and that this peptide appears to be an active site of enteroglucagon.

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Trophic effects of glicentin on rat small-intestinal mucosa in vivo and in vitro

Myojo

Tsujikawa

Sasaki

et al. 1997

J Gastroenterol

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<b>TROPHIC EFFECT OF GLUCAGON-(<i>1-21</i>)-PEPTIDE ON THE RAT SMALL INTESTINE AND </b><b>COLON </b>

Abstract: Glucagon-(1-2])-peptide is an N-terminal fragment of glucagon and can be measured as enteroglucagon by radioimmunoassay. We evaluated the trophic effect of

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Trophic effects of glicentin on rat small-intestinal mucosa in vivo and in vitro

Trophic effects of glicentin on rat small-intestinal mucosa in vivo and in vitro

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