&lt;b&gt;Ovarian Asymmetry &lt;b/&gt;

Domı́nguez, Roberto; Morales, Leticia; Cruz, ME

doi:10.5016/1806-8774.2003v5p95

Cited by 11 publications

(27 citation statements)

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“…Several studies have shown that the neural information originating from each ovary is asymmetric [33,34]. Toth et al 2007 [35] provided evidence that more neurons are involved in the supraspinal innervation of the left ovary than of the right.…”

Section: Discussionmentioning

confidence: 99%

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

Morales¹,

Ricardo²,

Bolanos³

et al. 2007

Reprod Biol Endocrinol

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The present study evaluates the participation of the vagus nerve in pre-pubertal rats with unilateral ovariectomy on puberty onset, and on progesterone, testosterone and estradiol serum levels, and the compensatory responses of the ovary. Unilateral vagotomy did not modify the onset of puberty in unilaterally ovariectomized rats. Ovulation rates of animals with the left vagus nerve sectioned and the left ovary in-situ was lower than in rats with only unilateral ovariectomy. Sectioning the left vagus to 32-day old rats with the left ovary in-situ resulted in lower compensatory ovarian hypertrophy than in rats with right unilateral ovariectomy. Twenty-eight or 32-day old animals with sectioning of the right vagus nerve and the right ovary in situ showed higher compensatory ovulation. Twenty-eight -day old rats with the right ovary in situ had higher progesterone and testosterone levels than animals of the same age with the left ovary in-situ. Compared to animals with the right ovary in situ, animals treated at 32-days of age, sectioning the ipsi-lateral vagus nerve resulted in higher progesterone levels. Higher progesterone levels were observed in 28- and 32 days old rats with the left ovary in situ and left vagus nerve sectioned. Thirty-two day old animals with the right ovary in situ and right vagus nerve sectioned had higher progesterone levels than rats of the same age with the left ovary in situ and left vagus nerve sectioned. Left vagotomy to 28-day old rats with the left ovary in situ resulted in higher testosterone levels, a reverse response to that observed in animals with sectioning of the right vagus and the right ovary in situ. Thirty-two day old rats with the left ovary in situ and left vagus nerve sectioned showed lower testosterone levels than animals without vagotomy and with the left ovary in situ.Twenty-eight -day old animals with the left vagus sectioned and left ovary in situ had lower estradiol serum levels than rats without unilateral vagotomy, a response similar to that observed in 32-day old rats with the right ovary in situ and right vagus nerve sectioned. Present results suggest an asymmetric regulation of steroid hormones secretion by the vagus nerve innervations in animals with unilateral ovariectomy, and those differences in testosterone serum levels observed are associated to the ovary remaining in-situ, vagal innervation and age when the animals were treated.

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Section: Discussionmentioning

confidence: 99%

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

Morales¹,

Ricardo²,

Bolanos³

et al. 2007

Reprod Biol Endocrinol

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“…Evidence that the ovaries send neural information to several regions of the central nervous system (CNS) [3,4], and that this information participates in regulating gonadotropin secretion [3,4,5] has been documented. The ovaries share neural information [3,4], and the celiac-superior mesenteric ganglia (CG-MG) facilitate the communication between the ovaries [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The effects of pituitary hormones are modulated by neural signals arriving to the endocrine glands, indicating that the CNS regulates the functions of endocrine glands through hormonal and neural signals. The existence of neural pathways carrying information from the endocrine glands to the CNS [5,6] suggests that such neural information works to inform the CNS of the hormonal and/or neural signals requirements of the endocrine gland. Then, the endocrine glands receive specific neuroendocrine signals for its function, instead of having the CNS sending neuroendocrine signals without having precise information of the peripheral requirements [7].…”

Section: Introductionmentioning

confidence: 99%

The Ovarian Innervation Participates in the Regulation of Ovarian Functions

Cruz-Morales¹

2012

Endocrinol Metabol Syndrome

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The release of gonadotropins is the main endocrine signal regulating ovulation and the release of hormones by the ovaries. Several types of growth factors modulate the effects of gonadotropins on the follicular, luteal and interstitial compartments of the ovaries. During the last 30 years, numerous studies have indicated that the ovarian innervations play a role in modulating the effects that gonadotropin have on the ovaries' ability to ovulate and secrete steroid hormones. This literature review presents a summary of the experimental results obtained by analyzing the effects of stimulating or blocking the well-known neural pathways participating in the regulation of ovulation and secretion of steroid hormones. Together, the results suggest that various neurotransmitter systems modulate the effects of gonadotropins on ovulation and the ovaries capacity to secrete steroid hormones. In addition, the ovaries asymmetric capacity for ovulation and hormone secretion could be explained by the asymmetries in their innervations.

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“…It has been hypothesized that the actions of these hormones are modulated by the glands receiving peripheral innervations, such as the vagus nerve and the superior ovarian nerve [1,20,22,26-28]. …”

Section: Introductionmentioning

confidence: 99%

Effects of acute unilateral ovariectomy to pre-pubertal rats on steroid hormones secretion and compensatory ovarian responses

Morales‐Ledesma¹,

Ramírez²,

Vieyra³

et al. 2011

Reprod Biol Endocrinol

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In the present study we analyzed the existence of asymmetry in the secretion of steroid hormones in pre-pubertal female rats treated with unilateral ovariectomy (ULO) or unilateral perforation of the abdominal wall (sham-surgery). Treated rats were sacrificed at different times after surgery. Since sham-surgery had an apparent effect on the age of first vaginal estrous (FVE) and serum levels hormone, the results of the sham surgery groups were used to assess the effects of their respective surgery treatment groups. On the day of FVE, compensatory ovulation (CO) and compensatory ovarian hypertrophy (COH) were similar in animals with ULO, regardless of the ovary remaining in situ. In ULO treated animals, progesterone (P4) levels were higher than in animals with sham-surgery one hour after treatment but lower in rats sacrificed at FEV. Left-ULO resulted in lower testosterone (T) concentration 48 and 72 hours after surgery. In rats with Right-ULO lower T concentrations were observed in rats sacrificed one or 72 hours after surgery, and at FVE. ULO (left or right) resulted in lower estradiol (E2) concentrations one or 72 hours after treatment. In rats with Left-ULO, E2 levels were higher 48 hours after surgery and at FVE. Left-ULO resulted in higher levels of follicle stimulating hormone (FSH) five hours after surgery and at FVE. FSH levels were higher in rats with Right-ULO sacrificed on FVE. The present results suggest that in the pre-pubertal rat both ovaries have similar capacities to secrete P4, and that the right ovary has a higher capacity to secrete E2. Taken together, the present results support the idea that the effects of ULO result from the decrease in glandular tissue and changes in the neural information arising from the ovary.

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<b>Ovarian Asymmetry <b/>

Cited by 11 publications

References 0 publications

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses

The Ovarian Innervation Participates in the Regulation of Ovarian Functions

Effects of acute unilateral ovariectomy to pre-pubertal rats on steroid hormones secretion and compensatory ovarian responses

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