<b><i>Rhodiola rosea</i></b> in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial

Abstract

Background:Rhodiola rosea roots and rhizomes are a herbal medicine for temporary relief of stress symptoms such as fatigue and sensed weakness. A daily dosage of 400 mg is recommended. Methods: A dry ethanolic extract of R. rosea (WS® 1375) was studied in 100 subjects with prolonged or chronic fatigue symptoms. In an uncontrolled, open-label multicenter clinical trial, the subjects were administered 2 × 200 mg WS® 1375 over 8 weeks. Outcome measures were scales and tests related to fatigue. They were evaluated in an exploratory data analysis to generate hypotheses regarding efficacy. The pilot character of the trial is marked by its broad focus on subjects suffering from fatigue in general and by its comparatively long duration. Results: The greatest change was observed after 1 week of treatment. The fatigue symptoms continued to decline further, with statistically significant improvement at week 8. The safety assessments of WS® 1375 during the trial proved to be favorable, with most adverse events being of mild intensity and not related to the study drug. Conclusions: The results indicate that 2 × 200 mg WS® 1375 may be an effective treatment in subjects suffering from prolonged or chronic fatigue. The safety and tolerability of WS® 1375 also presented a favorable profile.

Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event‐related potential dual task study

“…The main findings from the dual task paradigm were a a significant decrease in reaction times for all conditions b a significant decrease in dual task costs, determined as the differ- Taking into account previous literature on dual task effects on ERPs (Kramer, Wickens, & Donchin, 1985;Hoffman, Houck, MacMillan, Simons, & Oatman, 1985;Schubert, Johannes, et al, 1998), this pattern of results is compatible with the view of increased processing resources at week 6 and 12 compared with baseline, as the P3 amplitude has been (among other factors) related to the available (respectively, invested) processing resources (Hahn et al, 2011;Polich, 2007) in dual task and other paradigms (Matthews, Garry, Frances, & Summers, 2006;Sirevaag et al, 1989). With regard to previous results obtained for R. rosea, several studies have shown a positive effect on mental fatigue (Ishaque et al, 2012;Kang et al, 2015;Lekomtseva et al, 2017;Punja et al, 2014;Shevtsov et al, 2003). Recent evidence suggests that mental fatigue is related to depleted resources and, moreover, that "dual-task tests are most effective for inducing mental fatigue whilst maintaining arousal" (O'Keeffe, Hodder, & Lloyd, 2020).…”

“…to alleviate stress related symptoms (Anghelescu et al, 2018;Cropley et al, 2015;Edwards et al, 2012;Lazarova et al, 1986;Vasileva et al, 2017;Xia et al, 2016) and mental fatigue (Ishaque et al, 2012;Kang et al, 2015;Lekomtseva et al, 2017;Punja et al, 2014;Shevtsov et al, 2003), a dual task paradigm was implemented. Such paradigms tax the cognitive system, as they require the allocation of mental resources to two competing stimulus streams.…”

Rho, a Fraction From Rhodiola crenulate, Ameliorates Hepatic Steatosis in Mice Models

“…Numerous studies have shown that R. crenulata has neuroprotective, anti-tumor, anti-inflammatory, anti-depression, anti-fatigue, immune regulation, and other effects (Lekomtseva et al, 2017 ; Wei et al, 2017 ). Lin et al indicated that R. crenulata root extract (RCE), which contained 3.5% salidroside, regulated hepatic glycogen, and lipid metabolism in vitro (HepG2 cells) and in vivo (SD rats) via activation of the AMPK pathway (Lin et al, 2016 ).…”

Phytochemical, Antibacterial and Antioxidant Activity Evaluation of Rhodiola crenulata

“…was used for treating diarrhea, scald, neural paralysis and erysipelas. Gradually, the hemostatic agents, or endermic liniments for burns and contusions which contained ingredients of Rhodiola were developed [ 8 , 9 , 10 ].…”