<b>Hangebyakujutsutenmato can Decrease the Adverse Effects of Opioids in Chronic Pain Patients : Two Case Reports</b>

Abstract

We report on two cases of patients with chronic pain treated with opioid analgesics. They did not continue their treatment with opioid because of side effects. An 88 year-old female complained of low back and leg pain caused by lumbar spinal canal stenosis. She also complained of dizziness, nausea and appetite loss after a course of weak oral opioid was administered. We thought it necessary to improve her general condition and digestive sickness following treatment for pain, and administered 5 g/day of hangebyakujutsutemmato. After the administration of this hangebyakujutsutemmato, her general condition improved, and we could administer various analgesics. A 62 year-old female complained of dull headache, right neck pain and stiffness of tear and mouth due to fibromyalgia and collagen disease dating back several years. Her pain was reduced by the combined administration of a strong opioid and an immunosuppressive agent. However, she complained of severe dizziness, nausea and appetite loss after the commencement of drug therapy. Her general condition improved markedly, through the administration of 5 g/day of hangebyakujutsutemmato, and she was able to continue her treatment of chronic pain without deleterious events. In conclusion, in patients treated with opioids for chronic pain, dizziness, dull headache, nausea, vomiting and loss of appetite is often seen. Therefore, we emphasize that the combined administration of hangebyakujutsutemmato and opioids can be beneficial for the treatment of chronic pain patients. chronic pain, opioid, hangebyakujutsutemmato

Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study

“…Regarding its potential as a therapy for PPPD, HBT has been reported as a potential treatment for CSD[ 13 , 16 , 17 ]. In addition, some reports indicated that HBT was effective in preventing dizziness caused by opioids[ 18 ] or pregabalin[ 19 ]. Thus, HBT is a promising drug based on its demonstrated effects on dizziness.…”

Effect of hangebyakujutsutemmato on pregabalin‐induced dizziness in a rat model of neuropathic pain

“…The Japanese kampo medicine hangebyakujutsutemmato (HBT), however, also known as ‘banxiabaizhutianmatang’ in Chinese traditional herbal medicine, has been used to prevent dizziness and nausea . Recently, Hamaguchi et al reported that HBT was effective in preventing dizziness caused by opioids . Furthermore, Onaka et al reported that HBT was effective in treating dizziness resulting from neuropathic pain treatments, including pregabalin .…”