Abstract:Bladder pain is a most prominent feature of interstitial cystitis ⁄ painful bladder syndrome (IC ⁄ PBS), but unfortunately the efficacy of current analgesic s was thought to be insufficient in many patients with IC. Despite the clinical significance of bladder pain, there have been only a few research efforts to elucidate the mechanisms of this chronic pain and its pathophysiology remains poorly understood. One of the reasons is the lack of well-characterized experimental animal models of bladder pain. Hence, … Show more
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